Literature DB >> 3439797

Phenotypic expression and genetic heterogeneity of lincosamide inactivation in Staphylococcus spp.

R Leclercq1, A Brisson-Noël, J Duval, P Courvalin.   

Abstract

We examined the resistance phenotype and the genetic basis of lincosamide modification in 25 clinical isolates of Staphylococcus spp. inactivating lincomycin and clindamycin. The strains were resistant to high levels of lincomycin but remained susceptible to clindamycin. However, MBCs and inoculum effects showed that the activity of clindamycin was impaired. The distribution in these strains of nucleotide sequences related to linA and linA', the genes encoding lincosamide nucleotidylation in Staphylococcus haemolyticus BM4610 and S. aureus BM4611, respectively, was studied by dot blot hybridization. The genes responsible for lincosamide inactivation in Staphylococcus spp. were found to constitute a family of related sequences which are not species specific.

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Year:  1987        PMID： 3439797      PMCID： PMC175821          DOI： 10.1128/AAC.31.12.1887

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  [Not Available].

Authors:  Y CHABBERT
Journal:  Ann Inst Pasteur (Paris)       Date:  1956-06

2.  Nucleotide sequence of the constitutive macrolide-lincosamide-streptogramin B resistance plasmid pNE131 from Staphylococcus epidermidis and homologies with Staphylococcus aureus plasmids pE194 and pSN2.

Authors:  B C Lampson; J T Parisi
Journal:  J Bacteriol       Date:  1986-09       Impact factor: 3.490

3.  Nucleotide sequence of gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus.

Authors:  A Brisson-Noël; P Courvalin
Journal:  Gene       Date:  1986       Impact factor: 3.688

4.  Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis.

Authors:  M Monod; C Denoya; D Dubnau
Journal:  J Bacteriol       Date:  1986-07       Impact factor: 3.490

Review 5.  Studies of antimicrobial resistance genes using DNA probes.

Authors:  F C Tenover
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191

6.  A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.

Authors:  J Messing; J Vieira
Journal:  Gene       Date:  1982-10       Impact factor: 3.688

Review 7.  Evolution and transfer of aminoglycoside resistance genes under natural conditions.

Authors:  P Trieu-Cuot; P Courvalin
Journal:  J Antimicrob Chemother       Date:  1986-10       Impact factor: 5.790

Review 8.  Clindamycin: a review of fifteen years of experience.

Authors:  V K Dhawan; H Thadepalli
Journal:  Rev Infect Dis       Date:  1982 Nov-Dec

9.  Two new types of resistance to lincomycin in pathogenic staphylococci from animals.

Authors:  L A Devriese
Journal:  Ann Microbiol (Paris)       Date:  1980 Nov-Dec

10.  Multiplicity of macrolide-lincosamide-streptogramin antibiotic resistance determinants.

Authors:  P Courvalin; H Ounissi; M Arthur
Journal:  J Antimicrob Chemother       Date:  1985-07       Impact factor: 5.790
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  12 in total

1.  Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.

Authors:  L Zarantonelli; G Borthagaray; E H Lee; W M Shafer
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

2.  Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci.

Authors:  G Lina; A Quaglia; M E Reverdy; R Leclercq; F Vandenesch; J Etienne
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

Review 3.  Genotypic approach to the study of bacterial resistance to antibiotics.

Authors:  P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

Review 4.  Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria.

Authors:  R Leclercq; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

5.  Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus.

Authors:  Christine D Steward; Patti M Raney; Allison K Morrell; Portia P Williams; Linda K McDougal; Laura Jevitt; John E McGowan; Fred C Tenover
Journal:  J Clin Microbiol       Date:  2005-04       Impact factor: 5.948

6.  Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides.

Authors:  Gabriela Novotna; Václava Adamkova; Jiri Janata; Oto Melter; Jaroslav Spizek
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

7.  Occurrence of the Campylobacter resistance gene tetO in Enterococcus and Streptococcus spp.

Authors:  R Zilhao; B Papadopoulou; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

8.  Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides.

Authors:  L Wondrack; M Massa; B V Yang; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

Review 9.  Bacterial resistance to antimicrobial agents: selected problems in France, 1996 to 1998.

Authors:  H Aubry-Damon; P Courvalin
Journal:  Emerg Infect Dis       Date:  1999 May-Jun       Impact factor: 6.883

10.  Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system.

Authors:  J Sutcliffe; A Tait-Kamradt; L Wondrack
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191
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