Literature DB >> 3091456

Nucleotide sequence of gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus.

A Brisson-Noël, P Courvalin.   

Abstract

We have determined the nucleotide sequence of gene linA in plasmid pIP855, which confers resistance to lincomycin by inactivating it in Staphylococcus haemolyticus. The gene was defined by start and stop codons and an open reading frame of 483 bp corresponding to a product with an Mr of 19020. The apparent size of the resistance-conferring protein was 21 kDa, when a minicell extract was electrophoresed in the sodium dodecyl sulfate-polyacrylamide gels. Full expression of linA was obtained both in Escherichia coli and Bacillus subtilis.

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Year:  1986        PMID： 3091456     DOI： 10.1016/0378-1119(86)90213-1

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  16 in total

Review 1.  Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors:  M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

2.  Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci.

Authors:  G Lina; A Quaglia; M E Reverdy; R Leclercq; F Vandenesch; J Etienne
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

3.  DNA microarray for detection of macrolide resistance genes.

Authors:  Marco Cassone; Marco M D'Andrea; Francesco Iannelli; Marco R Oggioni; Gian Maria Rossolini; Gianni Pozzi
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

4.  Identification of the novel lincosamide resistance gene lnu(E) truncated by ISEnfa5-cfr-ISEnfa5 insertion in Streptococcus suis: de novo synthesis and confirmation of functional activity in Staphylococcus aureus.

Authors:  Qin Zhao; Sarah Wendlandt; Hui Li; Jun Li; Congming Wu; Jianzhong Shen; Stefan Schwarz; Yang Wang
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191

Review 5.  Mobile Genetic Elements Associated with Antimicrobial Resistance.

Authors:  Sally R Partridge; Stephen M Kwong; Neville Firth; Slade O Jensen
Journal:  Clin Microbiol Rev       Date:  2018-08-01       Impact factor: 26.132

6.  A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.

Authors:  G Novotna; J Janata
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

7.  Characterization of a Bacteroides mobilizable transposon, NBU2, which carries a functional lincomycin resistance gene.

Authors:  J Wang; N B Shoemaker; G R Wang; A A Salyers
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

8.  A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.

Authors:  B Bozdogan; L Berrezouga; M S Kuo; D A Yurek; K A Farley; B J Stockman; R Leclercq
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

9.  Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. reuteri DSM 17938.

Authors:  Anna Rosander; Eamonn Connolly; Stefan Roos
Journal:  Appl Environ Microbiol       Date:  2008-08-08       Impact factor: 4.792

Review 10.  Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.

Authors:  Stefan Schwarz; Jianzhong Shen; Kristina Kadlec; Yang Wang; Geovana Brenner Michael; Andrea T Feßler; Birte Vester
Journal:  Cold Spring Harb Perspect Med       Date:  2016-11-01       Impact factor: 6.915
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