| Literature DB >> 34383231 |
Zhipeng Qi1, Jiashuo Li1, Minghui Li1, Xianchao Du1, Lei Zhang1, Shuang Wang1, Bin Xu1, Wei Liu1, Zhaofa Xu1, Yu Deng2.
Abstract
Epigenetics play an essential role in the occurrence and improvement of many diseases. Evidence shows that epigenetic modifications are crucial to the regulation of gene expression. DNA methylation is closely linked to embryonic development in mammalian. In recent years, epigenetic drugs have shown unexpected therapeutic effects on neurological diseases, leading to the study of the epigenetic mechanism in neurodegenerative diseases. Unlike genetics, epigenetics modify the genome without changing the DNA sequence. Research shows that epigenetics is involved in all aspects of neurodegenerative diseases. The study of epigenetic will provide valuable insights into the molecular mechanism of neurodegenerative diseases, which may lead to new treatments and diagnoses. This article reviews the role of epigenetic modifications neurodegenerative diseases with dyskinesia, and discusses the therapeutic potential of epigenetic drugs in neurodegenerative diseases.Entities:
Keywords: Epigenetic; Motor dysfunction; Nervous system; Neurodegeneration; Parkinson’s disease
Mesh：
Year: 2021 PMID： 34383231 DOI： 10.1007/s10571-021-01133-z
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 4.231