Jasmina Mallet1,2,3, Ophélia Godin4,5,6, Nicolas Mazer4,7,8, Yann Le Strat4,7,8, Frank Bellivier4,9, Raoul Belzeaux4,10,11, Bruno Etain4,9, Guillaume Fond4,12, Sébastien Gard4,13, Chantal Henry4,14, Marion Leboyer4,5,6,15, Pierre-Michel Llorca4,16, Joséphine Loftus4,17, Emilie Olié4,18, Christine Passerieux4,19,20, Mircea Polosan4,21, Raymund Schwan7,22, Paul Roux4,19,20, Caroline Dubertret4,7,8. 1. Fondation Fondamental, Créteil, France. jasmina.mallet@aphp.fr. 2. Faculté de médecine, AP-HP, Department of Psychiatry, Université de Paris, Louis Mourier Hospital, CHU Louis Mourier, 178 rue des Renouillers, 92700, Colombes, France. jasmina.mallet@aphp.fr. 3. INSERM UMR1266, Institute of Psychiatry and Neuroscience of Paris, University Paris Descartes, Paris, France. jasmina.mallet@aphp.fr. 4. Fondation Fondamental, Créteil, France. 5. UMR_S955, UPEC, Créteil, France Inserm, Université Paris-Est, U955, Equipe 15 Psychiatrie génétique, Créteil, France. 6. AP-HP, Hôpital H. Mondor-A. Chenevier, Pôle de psychiatrie, Créteil, France. 7. Faculté de médecine, AP-HP, Department of Psychiatry, Université de Paris, Louis Mourier Hospital, CHU Louis Mourier, 178 rue des Renouillers, 92700, Colombes, France. 8. INSERM UMR1266, Institute of Psychiatry and Neuroscience of Paris, University Paris Descartes, Paris, France. 9. AP-HP, GH Saint-Louis-Lariboisière-Fernand Widal, Pôle Neurosciences Tête et Cou, INSERM UMRS 1144, University Paris Diderot, Paris, France. 10. AP-HM, Department of Psychiatry, Marseille, France. 11. INT-UMR7289, CNRS Aix Marseille University, Marseille, France. 12. AP-HM, Aix-Marseille University, School of Medicine-La Timone Medical Campus, EA 3279: CEReSS-Health Service Research and Quality of Life Center, 27 Boulevard Jean Moulin, 13005, Marseille, France. 13. Centre Expert Troubles Bipolaires, Service de Psychiatrie Adulte, Hôpital Charles-Perrens, Bordeaux, France. 14. Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris Psychiatrie and Neurosciences, 75014, Paris, France. 15. Fondation de Cooperation Scientifique, Fondation FondaMental, Créteil, France. 16. CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, EA 7280, Clermont-Ferrand, France. 17. Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco, France. 18. Department of Emergency Psychiatry and Acute Care, CHU Montpellier, INSERM U1061, Montpellier University, Montpellier, France. 19. Service Universitaire de Psychiatrie d'Adultes et d'Addictologie, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157, Le Chesnay, France. 20. CESP, INSERM, Université Paris Saclay, Université de Versailles Saint-Quentin-En-Yvelines, 2 Avenue de la Source de la Bièvre, 78180, Montigny-le-Bretonneux, France. 21. Université Grenoble Alpes, Inserm, U1216, Grenoble Institut des Neurosciences, CHU Grenoble Alpes, 38000, Grenoble, France. 22. CHRU de Nancy et Pôle de Psychiatrie et Psychologie Clinique, Université de Lorraine, Centre Psychothérapique de Nancy, Nancy, France.
Abstract
OBJECTIVES: High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile. METHODS: We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed. RESULTS: The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (p < 0.01), and dyslexia and dysphasia for NRH (p = 0.01 and p = 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96-0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03-1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all p < 0.01) and less mood stabilizer prescription (p = 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index. CONCLUSIONS: Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.
OBJECTIVES: High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile. METHODS: We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed. RESULTS: The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (p < 0.01), and dyslexia and dysphasia for NRH (p = 0.01 and p = 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96-0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03-1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all p < 0.01) and less mood stabilizer prescription (p = 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index. CONCLUSIONS: Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.
Authors: Stefan Kloiber; Joshua D Rosenblat; Muhammad I Husain; Abigail Ortiz; Michael Berk; Joao Quevedo; Eduard Vieta; Michael Maes; Boris Birmaher; Jair C Soares; Andre F Carvalho Journal: Neurosci Biobehav Rev Date: 2020-02-05 Impact factor: 8.989
Authors: Alice C Burnett; Peter J Anderson; Robert M Joseph; Elizabeth N Allred; T Michael O'Shea; Karl C K Kuban; Alan Leviton Journal: J Pediatr Date: 2018-01-11 Impact factor: 4.406