| Literature DB >> 34374484 |
Marcarious M Tantuoyir1,2,3, Nima Rezaei1,4,5.
Abstract
Entities:
Keywords: IgG; IgM; SARS-CoV-2; antibody; coronavirus; diagnosis
Mesh:
Substances:
Year: 2021 PMID: 34374484 PMCID: PMC8426956 DOI: 10.1002/cbin.11686
Source DB: PubMed Journal: Cell Biol Int ISSN: 1065-6995 Impact factor: 4.473
A summary of SARS‐CoV‐2 structural proteins, binding sites, and their roles (Astuti & Ysrafil, 2020)
| Protein Name | Binding mechanism | Role |
|---|---|---|
| Spike protein (S) | Utilizes an N‐terminal signal sequence to gain access to the ER (endoplasmic reticulum) | Mediates attachment to host receptors |
| Nucleocapsid protein (N) | Binds the viral genome in a beads‐on‐a‐string type conformation | Tethers the viral genome to replicase‐transcriptase complex, packages the encapsulated genome into viral particles |
| Envelope protein (E) | A transmembrane protein with ion channel activity | Facilitates assembly and release of the virus; involved in ion channel activity |
| Membrane protein (M) | Binds to nucleocapsid | Promotes membrane curvature |