Literature DB >> 34365520

Cholesterol in GPCR Structures: Prevalence and Relevance.

Parijat Sarkar1, Amitabha Chattopadhyay2.   

Abstract

Bound cholesterol molecules are emerging as important hallmarks of GPCR structures. In this commentary, we analyze their statistical prevalence and biological relevance.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Bound cholesterol; Cholesterol sensitivity; Cryo-EM; Crystal structure; GPCRs

Mesh：

Substances：

Year:  2021        PMID： 34365520     DOI： 10.1007/s00232-021-00197-8

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  60 in total

1.  High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Authors:  Vadim Cherezov; Daniel M Rosenbaum; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Peter Kuhn; William I Weis; Brian K Kobilka; Raymond C Stevens
Journal:  Science       Date:  2007-10-25       Impact factor: 47.728

2.  A monoclonal antibody for G protein-coupled receptor crystallography.

Authors:  Peter W Day; Søren G F Rasmussen; Charles Parnot; Juan José Fung; Asna Masood; Tong Sun Kobilka; Xiao-Jie Yao; Hee-Jung Choi; William I Weis; Daniel K Rohrer; Brian K Kobilka
Journal:  Nat Methods       Date:  2007-10-21       Impact factor: 28.547

Review 3.  Methodological advances: the unsung heroes of the GPCR structural revolution.

Authors:  Eshan Ghosh; Punita Kumari; Deepika Jaiman; Arun K Shukla
Journal:  Nat Rev Mol Cell Biol       Date:  2015-01-15       Impact factor: 94.444

Review 4.  Molecular switches in GPCRs.

Authors:  Slawomir Filipek
Journal:  Curr Opin Struct Biol       Date:  2019-05-10       Impact factor: 6.809

Review 5.  New Binding Sites, New Opportunities for GPCR Drug Discovery.

Authors:  H C Stephen Chan; Yi Li; Thamani Dahoun; Horst Vogel; Shuguang Yuan
Journal:  Trends Biochem Sci       Date:  2019-01-03       Impact factor: 13.807

Review 6.  Molecular mechanisms of protein-cholesterol interactions in plasma membranes: Functional distinction between topological (tilted) and consensus (CARC/CRAC) domains.

Authors:  Jacques Fantini; Coralie Di Scala; Carlos J Baier; Francisco J Barrantes
Journal:  Chem Phys Lipids       Date:  2016-03-14       Impact factor: 3.329

Review 7.  Cholesterol and the interaction of proteins with membrane domains.

Authors:  Richard M Epand
Journal:  Prog Lipid Res       Date:  2006-03-20       Impact factor: 16.195

8.  Cholesteryl Hemisuccinate Is Not a Good Replacement for Cholesterol in Lipid Nanodiscs.

Authors:  Bozena Augustyn; Piotr Stepien; Chetan Poojari; Edouard Mobarak; Agnieszka Polit; Anna Wisniewska-Becker; Tomasz Róg
Journal:  J Phys Chem B       Date:  2019-11-12       Impact factor: 2.991

Review 9.  A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes.

Authors:  Martin Caffrey
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-01-01       Impact factor: 1.056

10.  How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains.

Authors:  Jacques Fantini; Francisco J Barrantes
Journal:  Front Physiol       Date:  2013-02-28       Impact factor: 4.566
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  1 in total

Review 1.  Cholesterol-dependent endocytosis of GPCRs: implications in pathophysiology and therapeutics.

Authors:  G Aditya Kumar; Amitabha Chattopadhyay
Journal:  Biophys Rev       Date:  2021-11-12
  1 in total

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