Annika van Welzen1, Matti Hoch2, Philip Wahl3, Frank Weber4, Susen Rode1, Julia Katharina Tietze1, Lars Boeckmann1, Steffen Emmert1, Alexander Thiem1. 1. Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany. 2. Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany. 3. Diaspective Vision GmbH, Pepelow, Germany. 4. Department for Biostatistics and Informatics in Medicine, University Medical Center, Rostock, Germany.
Abstract
INTRODUCTION: Cold atmospheric plasma (CAP) has positive effects on wound healing and antimicrobial properties. However, an ongoing challenge is the development of specific modes of application for different clinical indications. OBJECTIVES: We investigated in a prospective pilot study the response and tolerability of a newly developed CAP wound dressing for the acute healing of split skin graft donor sites compared to conventional therapy. METHODS: We applied both treatments to each patient (n = 10) for 7 days and measured 4 parameters of wound healing every other day (i.e., 1,440 measurements) using a hyperspectral imaging camera. Additionally, we evaluated the clinical appearance and pain levels reported by the patients. RESULTS: The CAP wound dressing was superior to the control (p < 0.001) in the improvement of 3 wound parameters, that is, deep tissue oxygen saturation, hemoglobin distribution, and tissue water distribution. CAP was well tolerated, and pain levels were lower in CAP-treated wound areas. CONCLUSION: CAP wound dressing is a promising new tool for acute wound healing.
INTRODUCTION: Cold atmospheric plasma (CAP) has positive effects on wound healing and antimicrobial properties. However, an ongoing challenge is the development of specific modes of application for different clinical indications. OBJECTIVES: We investigated in a prospective pilot study the response and tolerability of a newly developed CAP wound dressing for the acute healing of split skin graft donor sites compared to conventional therapy. METHODS: We applied both treatments to each patient (n = 10) for 7 days and measured 4 parameters of wound healing every other day (i.e., 1,440 measurements) using a hyperspectral imaging camera. Additionally, we evaluated the clinical appearance and pain levels reported by the patients. RESULTS: The CAP wound dressing was superior to the control (p < 0.001) in the improvement of 3 wound parameters, that is, deep tissue oxygen saturation, hemoglobin distribution, and tissue water distribution. CAP was well tolerated, and pain levels were lower in CAP-treated wound areas. CONCLUSION: CAP wound dressing is a promising new tool for acute wound healing.
Authors: Jan P Vandenbroucke; Erik von Elm; Douglas G Altman; Peter C Gøtzsche; Cynthia D Mulrow; Stuart J Pocock; Charles Poole; James J Schlesselman; Matthias Egger Journal: Ann Intern Med Date: 2007-10-16 Impact factor: 25.391
Authors: Georg Daeschlein; Inga Langner; Thomas Wild; Sebastian von Podewils; Claudia Sicher; Thomas Kiefer; Michael Jünger Journal: Clin Hemorheol Microcirc Date: 2017 Impact factor: 2.375
Authors: Thomas Wild; Markus Becker; Jochen Winter; Nicole Schuhschenk; Georg Daeschlein; Frank Siemers Journal: J Wound Care Date: 2018-01-02 Impact factor: 2.072
Authors: Georg Daeschlein; Rico Rutkowski; Stine Lutze; Sebastian von Podewils; Claudia Sicher; Thomas Wild; Hans-Robert Metelmann; Thomas von Woedkte; Michael Jünger Journal: Biomed Tech (Berl) Date: 2018-10-25 Impact factor: 1.411
Authors: Julia Heinlin; Julia L Zimmermann; Florian Zeman; Wolfram Bunk; Georg Isbary; Michael Landthaler; Tim Maisch; Roberto Monetti; Gregor Morfill; Tetsuji Shimizu; Julia Steinbauer; Wilhelm Stolz; Sigrid Karrer Journal: Wound Repair Regen Date: 2013-08-12 Impact factor: 3.617
Authors: F Brehmer; H A Haenssle; G Daeschlein; R Ahmed; S Pfeiffer; A Görlitz; D Simon; M P Schön; D Wandke; S Emmert Journal: J Eur Acad Dermatol Venereol Date: 2014-03-25 Impact factor: 6.166
Authors: Robert Sucher; Alvanos Athanasios; Hannes Köhler; Tristan Wagner; Maximilian Brunotte; Andri Lederer; Ines Gockel; Daniel Seehofer Journal: Int J Surg Case Rep Date: 2019-08-31