Literature DB >> 34358459

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.

Ke Cong, Min Peng, Arne Nedergaard Kousholt, Wei Ting C Lee, Silviana Lee, Sumeet Nayak, John Krais, Pamela S VanderVere-Carozza, Katherine S Pawelczak, Jennifer Calvo, Nicholas J Panzarino, John J Turchi, Neil Johnson, Jos Jonkers, Eli Rothenberg, Sharon B Cantor.   

Abstract

Entities:  

Year:  2021        PMID： 34358459     DOI： 10.1016/j.molcel.2021.07.015

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


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  12 in total

Review 1.  BRCA1-Dependent and Independent Recruitment of PALB2-BRCA2-RAD51 in the DNA Damage Response and Cancer.

Authors:  Tzeh Keong Foo; Bing Xia
Journal:  Cancer Res       Date:  2022-09-16       Impact factor: 13.312

2.  Distinct roles of treatment schemes and BRCA2 on the restoration of homologous recombination DNA repair and PARP inhibitor resistance in ovarian cancer.

Authors:  Jung-Min Lee; Jayakumar R Nair; Tzu-Ting Huang; Sandra Sczerba Burkett; Mayank Tandon; Tomomi M Yamamoto; Nitasha Gupta; Benjamin G Bitler
Journal:  Oncogene       Date:  2022-10-12       Impact factor: 8.756

3.  A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response.

Authors:  Jean-François Lemay; Edlie St-Hilaire; Daryl A Ronato; Yuandi Gao; François Bélanger; Sari Gezzar-Dandashi; Aimé Boris Kimenyi Ishimwe; Christina Sawchyn; Dominique Lévesque; Mary McQuaid; François-Michel Boisvert; Frédérick A Mallette; Jean-Yves Masson; Elliot A Drobetsky; Hugo Wurtele
Journal:  PLoS Biol       Date:  2022-10-10       Impact factor: 9.593

4.  Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells.

Authors:  Stephanie Tirman; Annabel Quinet; Matthew Wood; Alice Meroni; Emily Cybulla; Jessica Jackson; Silvia Pegoraro; Antoine Simoneau; Lee Zou; Alessandro Vindigni
Journal:  Mol Cell       Date:  2021-10-07       Impact factor: 19.328

5.  REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.

Authors:  Angelo Taglialatela; Giuseppe Leuzzi; Vincenzo Sannino; Raquel Cuella-Martin; Jen-Wei Huang; Foon Wu-Baer; Richard Baer; Vincenzo Costanzo; Alberto Ciccia
Journal:  Mol Cell       Date:  2021-09-10       Impact factor: 19.328

6.  In Vivo Targeting Replication Protein A for Cancer Therapy.

Authors:  Pamela S VanderVere-Carozza; Navnath S Gavande; Shadia I Jalal; Karen E Pollok; Elmira Ekinci; Joshua Heyza; Steve M Patrick; Andi Masters; John J Turchi; Katherine S Pawelczak
Journal:  Front Oncol       Date:  2022-02-18       Impact factor: 6.244

Review 7.  DNA repair defects in cancer and therapeutic opportunities.

Authors:  Jessica L Hopkins; Li Lan; Lee Zou
Journal:  Genes Dev       Date:  2022-03-01       Impact factor: 12.890

8.  Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant Brca1 Proficient and Deficient Murine Ovarian Cells.

Authors:  Michela Chiappa; Federica Guffanti; Martina Anselmi; Monica Lupi; Nicolò Panini; Lisa Wiesmüller; Giovanna Damia
Journal:  Cancers (Basel)       Date:  2022-04-01       Impact factor: 6.639

9.  XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine.

Authors:  María José Peña-Gómez; Marina Suárez-Pizarro; Iván V Rosado
Journal:  Int J Mol Sci       Date:  2022-01-14       Impact factor: 5.923

10.  Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.

Authors:  Lindsey M Jackson; Ashna Dhoonmoon; Anastasia Hale; Kady A Dennis; Emily M Schleicher; Claudia M Nicolae; George-Lucian Moldovan
Journal:  Nucleic Acids Res       Date:  2021-12-16       Impact factor: 16.971
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