Literature DB >> 3435497

Effect of disulfiram on the pre-steady-state burst in the reactions of sheep liver cytoplasmic aldehyde dehydrogenase.

T M Kitson1.   

Abstract

Stopped-flow spectrophotometric experiments show that modification by disulfiram not only lowers the steady-state rates but also decreases the size of bursts seen in both dehydrogenase and esterase reactions catalysed by sheep liver cytoplasmic aldehyde dehydrogenase. This observation is consistent with the proposal that a catalytically essential group is modified by disulfiram and that this group mediates both dehydrogenase and esterase activities.

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Year:  1987        PMID： 3435497      PMCID： PMC1148651          DOI： 10.1042/bj2480989

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Kinetic studies of liver alcohol dehydrogenase.

Authors:  K DALZIEL
Journal:  Biochem J       Date:  1962-08       Impact factor: 3.857

2.  Kinetic studies on the esterase activity of cytoplasmic sheep liver aldehyde dehydrogenase.

Authors:  A K MacGibbon; S J Haylock; P D Buckley; L F Blackwell
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

Review 3.  The disulfiram--ethanol reaction: a review.

Authors:  T M Kitson
Journal:  J Stud Alcohol       Date:  1977-01

4.  Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity.

Authors:  R I Feldman; H Weiner
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

5.  Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1983-08-01       Impact factor: 3.857

6.  Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1982-06-01       Impact factor: 3.857

7.  Purification and properties of sheep-liver aldehyde dehydrogenases.

Authors:  A K MacGibbon; R L Motion; K E Crow; P D Buckley; L F Blackwell
Journal:  Eur J Biochem       Date:  1979-06-01

8.  Kinetic properties of highly purified preparations of sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  G J Hart; F M Dickinson
Journal:  Biochem J       Date:  1982-06-01       Impact factor: 3.857

9.  The use of pH-gradient ion-exchange chromatography to separate sheep liver cytoplasmic aldehyde dehydrogenase from mitochondrial enzyme contamination, and observations on the interaction between the pure cytoplasmic enzyme and disulfiram.

Authors:  F M Dickinson; G J Hart; T M Kitson
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857

10.  The coenzyme-binding characteristics of highly purified preparations of sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  G J Hart; F M Dickinson
Journal:  Biochem J       Date:  1983-05-01       Impact factor: 3.857
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  2 in total

1.  Identification of a catalytically essential nucleophilic residue in sheep liver cytoplasmic aldehyde dehydrogenase.

Authors:  T M Kitson; J P Hill; G G Midwinter
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

2.  Reaction between sheep liver mitochondrial aldehyde dehydrogenase and various thiol-modifying reagents.

Authors:  K M Loomes; T M Kitson
Journal:  Biochem J       Date:  1989-07-01       Impact factor: 3.857
  2 in total

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