Literature DB >> 34352209

ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue.

Andrew S Mendiola1, Reshmi Tognatta1, Zhaoqi Yan1, Katerina Akassoglou2.   

Abstract

In this issue of Neuron, Shi et al. (2021) show a protective role for the low-density lipoprotein receptor (LDLR) in tau pathology. Brain overexpression of LDLR lowers apolipoprotein E (apoE), suppresses microglial activation, preserves myelin, and ameliorates neurodegeneration, pointing the way toward potential new therapies.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 34352209      PMCID： PMC8546493          DOI： 10.1016/j.neuron.2021.07.013

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   18.688


  10 in total

1.  LRP: a bright beacon at the blood-brain barrier.

Authors:  Joachim Herz
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

2.  Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.

Authors:  Mario Merlini; Victoria A Rafalski; Pamela E Rios Coronado; T Michael Gill; Maya Ellisman; Gayathri Muthukumar; Keshav S Subramanian; Jae Kyu Ryu; Catriona A Syme; Dimitrios Davalos; William W Seeley; Lennart Mucke; Robert B Nelson; Katerina Akassoglou
Journal:  Neuron       Date:  2019-02-05       Impact factor: 17.173

Review 3.  Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies.

Authors:  Che-Wei Chang; Eric Shao; Lennart Mucke
Journal:  Science       Date:  2021-02-26       Impact factor: 47.728

Review 4.  Lipoprotein receptors in Alzheimer's disease.

Authors:  Olav M Andersen; Thomas E Willnow
Journal:  Trends Neurosci       Date:  2006-09-26       Impact factor: 13.837

Review 5.  Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Authors:  Robert W Mahley; Yadong Huang
Journal:  Neuron       Date:  2012-12-06       Impact factor: 17.173

6.  Single-cell transcriptomic analysis of Alzheimer's disease.

Authors:  Hansruedi Mathys; Jose Davila-Velderrain; Zhuyu Peng; Fan Gao; Shahin Mohammadi; Jennie Z Young; Madhvi Menon; Liang He; Fatema Abdurrob; Xueqiao Jiang; Anthony J Martorell; Richard M Ransohoff; Brian P Hafler; David A Bennett; Manolis Kellis; Li-Huei Tsai
Journal:  Nature       Date:  2019-05-01       Impact factor: 49.962

7.  Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease.

Authors:  Jing-Fei Chen; Kun Liu; Bo Hu; Rong-Rong Li; Wendy Xin; Hao Chen; Fei Wang; Lin Chen; Rui-Xue Li; Shu-Yu Ren; Lan Xiao; Jonah R Chan; Feng Mei
Journal:  Neuron       Date:  2021-06-07       Impact factor: 18.688

8.  Risk factor for Alzheimer's disease breaks the blood-brain barrier.

Authors:  Makoto Ishii; Costantino Iadecola
Journal:  Nature       Date:  2020-05       Impact factor: 69.504

9.  Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.

Authors:  Yang Shi; Prabhakar Sairam Andhey; Christina Ising; Kairuo Wang; Lisa L Snipes; Kevin Boyer; Stephanie Lawson; Kaoru Yamada; Wei Qin; Melissa Manis; Javier Remolina Serrano; Bruno A Benitez; Robert E Schmidt; Maxim Artyomov; Jason D Ulrich; David M Holtzman
Journal:  Neuron       Date:  2021-06-21       Impact factor: 18.688

Review 10.  Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.

Authors:  Yun Chen; Michael R Strickland; Andrea Soranno; David M Holtzman
Journal:  Neuron       Date:  2020-11-10       Impact factor: 17.173
  10 in total
  1 in total

Review 1.  Synapses, Microglia, and Lipids in Alzheimer's Disease.

Authors:  Patrick J Paasila; Jason A Aramideh; Greg T Sutherland; Manuel B Graeber
Journal:  Front Neurosci       Date:  2022-01-12       Impact factor: 4.677
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.