Literature DB >> 14617749

LRP: a bright beacon at the blood-brain barrier.

Joachim Herz1.   

Abstract

Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection. By interacting with active tissue-type plasminogen activator, LDL receptor-related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family.

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Year:  2003        PMID： 14617749      PMCID： PMC259136          DOI： 10.1172/JCI20337

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  21 in total

1.  A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.

Authors:  X Cao; T C Südhof
Journal:  Science       Date:  2001-07-06       Impact factor: 47.728

2.  Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

Authors:  Elena Loukinova; Sripriya Ranganathan; Sergey Kuznetsov; Natalia Gorlatova; Mary M Migliorini; Dmitri Loukinov; Paula G Ulery; Irina Mikhailenko; Daniel A Lawrence; Dudley K Strickland
Journal:  J Biol Chem       Date:  2002-02-19       Impact factor: 5.157

3.  Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.

Authors:  Petra May; Y Krishna Reddy; Joachim Herz
Journal:  J Biol Chem       Date:  2002-03-20       Impact factor: 5.157

Review 4.  LRP: a multifunctional scavenger and signaling receptor.

Authors:  J Herz; D K Strickland
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

5.  Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor.

Authors:  T A Hembrough; J F Ruiz; A E Papathanassiu; S J Green; D K Strickland
Journal:  J Biol Chem       Date:  2001-01-17       Impact factor: 5.157

6.  Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells.

Authors:  H Barnes; B Larsen; M Tyers; P van Der Geer
Journal:  J Biol Chem       Date:  2001-03-20       Impact factor: 5.157

Review 7.  Genetics and ischaemic stroke.

Authors:  A Hassan; H S Markus
Journal:  Brain       Date:  2000-09       Impact factor: 13.501

8.  Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor.

Authors:  Sanjay K Mishra; Peter A Keyel; Matthew J Hawryluk; Nicole R Agostinelli; Simon C Watkins; Linton M Traub
Journal:  EMBO J       Date:  2002-09-16       Impact factor: 11.598

9.  ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.

Authors:  Guocheng He; Sarita Gupta; Ming Yi; Peter Michaely; Helen H Hobbs; Jonathan C Cohen
Journal:  J Biol Chem       Date:  2002-09-08       Impact factor: 5.157

10.  Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP).

Authors:  Christina Lutz; Johannes Nimpf; Marcel Jenny; Karl Boecklinger; Christiane Enzinger; Gerd Utermann; Gabriele Baier-Bitterlich; Gottfried Baier
Journal:  J Biol Chem       Date:  2002-08-21       Impact factor: 5.157
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  18 in total

1.  Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization.

Authors:  Ranjeet K Sinha; Xia V Yang; José A Fernández; Xiao Xu; Laurent O Mosnier; John H Griffin
Journal:  Arterioscler Thromb Vasc Biol       Date:  2016-01-21       Impact factor: 8.311

2.  Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.

Authors:  Martin J Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Pankaj D Mehta; Frances Prelli; David Quartermain; Thomas Wisniewski
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-20       Impact factor: 11.205

3.  Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.

Authors:  Enming J Su; Linda Fredriksson; Melissa Geyer; Erika Folestad; Jacqueline Cale; Johanna Andrae; Yamei Gao; Kristian Pietras; Kris Mann; Manuel Yepes; Dudley K Strickland; Christer Betsholtz; Ulf Eriksson; Daniel A Lawrence
Journal:  Nat Med       Date:  2008-06-22       Impact factor: 53.440

4.  Tissue and urokinase plasminogen activators instigate the degeneration of retinal ganglion cells in a mouse model of glaucoma.

Authors:  Shravan K Chintala
Journal:  Exp Eye Res       Date:  2015-10-22       Impact factor: 3.467

Review 5.  Agile delivery of protein therapeutics to CNS.

Authors:  Xiang Yi; Devika S Manickam; Anna Brynskikh; Alexander V Kabanov
Journal:  J Control Release       Date:  2014-06-21       Impact factor: 9.776

6.  t-PA reduces ischemic impairment of blood-brain barrier by strengthening endothelium junction.

Authors:  Zhongling Zhang; Xuhui Chen; Le Li; Keling Zhang; Shuqing Tian; Hongmei Gao; Hulun Li
Journal:  Neurol Sci       Date:  2013-02-20       Impact factor: 3.307

7.  Cancer and the blood-brain barrier: 'Trojan horses' for courses?

Authors:  M Mazza; I F Uchegbu; A G Schätzlein
Journal:  Br J Pharmacol       Date:  2008-06-30       Impact factor: 8.739

8.  Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.

Authors:  Petra May; Astrid Rohlmann; Hans H Bock; Kai Zurhove; Jamey D Marth; Eike D Schomburg; Jeffrey L Noebels; Uwe Beffert; J David Sweatt; Edwin J Weeber; Joachim Herz
Journal:  Mol Cell Biol       Date:  2004-10       Impact factor: 4.272

9.  Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma.

Authors:  ZhiHua Shi; Marcelo Rudzinski; Karen Meerovitch; Frédéric Lebrun-Julien; Elena Birman; Adriana Di Polo; H Uri Saragovi
Journal:  J Biol Chem       Date:  2008-08-13       Impact factor: 5.157

Review 10.  tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.

Authors:  Linda Fredriksson; Daniel A Lawrence; Robert L Medcalf
Journal:  Semin Thromb Hemost       Date:  2016-09-27       Impact factor: 4.180
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