Erling Tjora1, Georg Dimcevski2, Stephan L Haas3, Friedemann Erchinger2, Miroslav Vujasinovic3, Matthias Löhr3, Camilla Nøjgaard4, Srdan Novovic4, Imanta Ozola Zalite5, Aldis Pukitis5, Truls Hauge6, Anne Waage7, Stine Roug8, Evangelos Kalaitzakis9, Björn Lindkvist10, Søren Schou Olesen11, Trond Engjom12. 1. Pediatric Department, Haukeland University Hospital, Bergen, Norway; Center for Diabetes Research, University of Bergen, Bergen, Norway. Electronic address: erling.tjora@helse-bergen.no. 2. Department of Clinical Medicine, University of Bergen, Bergen, Norway. 3. Centre for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden. 4. Department of Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark. 5. Center of Gastroenterology, Hepatology and Nutrition, Pauls Stradins Clinical University Hospital, Riga, Latvia. 6. Department of Gastroenterology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 7. Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway. 8. Digestive Disease Center, Bispebjerg Hospital, Copenhagen, Denmark. 9. Copenhagen University Hospital/Herlev, University of Copenhagen, Copenhagen, Denmark. 10. Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 11. Center for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark. 12. Department of Clinical Medicine, University of Bergen, Bergen, Norway; Medical Department, Haukeland University Hospital, Bergen, Norway.
Abstract
BACKGROUND/ OBJECTIVES: Smoking and alcohol abuse are established risk factors for chronic pancreatitis (CP). Few studies have examined how exposure to smoking and alcohol abuse act as risk factors for complications in CP. Our aim was to examine associations between patient reported exposure to smoking and alcohol abuse and complications in CP in a large cohort of patients from the Scandinavian and Baltic countries. METHODS: We retrieved data on demographics, CP related complications and patients' histories of exposure to smoking and alcohol abuse from the Scandinavian Baltic Pancreatic Club database. Associations were investigated by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals. RESULTS: A complete history of smoking and alcohol exposure was available for 932 patients. In multivariate regression analyses, the presence of pain and exocrine pancreatic insufficiency were both significantly associated with history of smoking (OR 1.94 (1.40-2.68), p < 0.001 and OR 1.89 (1.36-2.62), p < 0.001, respectively) and alcohol abuse (OR 1.66 (1.21-2.26), p = 0.001 and 1.55 (1.14-2.11), p = 0.005, respectively). Smoking was associated with calcifications (OR 2.89 (2.09-3.96), p < 0.001), moderate to severe ductal changes (OR 1.42 (1.05-1.92), p = 0.02), and underweight (OR 4.73 (2.23-10.02), p < 0.001). History of alcohol abuse was associated with pseudocysts (OR 1.38 (1.00-1.90) p = 0.05) and diabetes mellitus (OR 1.44 (1.03-2.01), p = 0.03). There were significantly increased odds-ratios for several complications with increasing exposure to smoking and alcohol abuse. CONCLUSION: Smoking and alcohol abuse are both independently associated with development of complications in patients with CP. There seems to be a dose-dependent relationship between smoking and alcohol abuse and complications in CP.
BACKGROUND/ OBJECTIVES: Smoking and alcohol abuse are established risk factors for chronic pancreatitis (CP). Few studies have examined how exposure to smoking and alcohol abuse act as risk factors for complications in CP. Our aim was to examine associations between patient reported exposure to smoking and alcohol abuse and complications in CP in a large cohort of patients from the Scandinavian and Baltic countries. METHODS: We retrieved data on demographics, CP related complications and patients' histories of exposure to smoking and alcohol abuse from the Scandinavian Baltic Pancreatic Club database. Associations were investigated by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals. RESULTS: A complete history of smoking and alcohol exposure was available for 932 patients. In multivariate regression analyses, the presence of pain and exocrine pancreatic insufficiency were both significantly associated with history of smoking (OR 1.94 (1.40-2.68), p < 0.001 and OR 1.89 (1.36-2.62), p < 0.001, respectively) and alcohol abuse (OR 1.66 (1.21-2.26), p = 0.001 and 1.55 (1.14-2.11), p = 0.005, respectively). Smoking was associated with calcifications (OR 2.89 (2.09-3.96), p < 0.001), moderate to severe ductal changes (OR 1.42 (1.05-1.92), p = 0.02), and underweight (OR 4.73 (2.23-10.02), p < 0.001). History of alcohol abuse was associated with pseudocysts (OR 1.38 (1.00-1.90) p = 0.05) and diabetes mellitus (OR 1.44 (1.03-2.01), p = 0.03). There were significantly increased odds-ratios for several complications with increasing exposure to smoking and alcohol abuse. CONCLUSION: Smoking and alcohol abuse are both independently associated with development of complications in patients with CP. There seems to be a dose-dependent relationship between smoking and alcohol abuse and complications in CP.
Authors: Samuel Y Han; Darwin L Conwell; Philip T Diaz; Amy Ferketich; Christie Y Jeon; Dhiraj Yadav; Phil A Hart Journal: Pancreatology Date: 2022-08-11 Impact factor: 3.977
Authors: Luis F Lara; Solvejg Wastvedt; James S Hodges; Piotr Witkowski; Martin Wijkstrom; R Matthew Walsh; Vikesh K Singh; Sarah J Schwarzenberg; Timothy L Pruett; Andrew Posselt; Bashoo Naziruddin; Jaimie D Nathan; Katherine A Morgan; Rebecca Mitchell; Varvara A Kirchner; SriPrakash L Mokshagundam; Betul Hatipoglu; Timothy B Gardner; Martin L Freeman; Srinath Chinnakotla; Gregory J Beilman; Maisam Abu-El-Haija; Darwin L Conwell; Melena D Bellin Journal: Pancreas Date: 2021-07-01 Impact factor: 3.243