Xinye Wang1,2, Dawei Wang3, Sajid Umar1, Sheng Qin4, Qiong Ling4, Gregory C Gray5,6,7,8, Yuntao Liu9. 1. Global Health Research Center, Duke Kunshan University, Kunshan, China. 2. Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia. 3. Emergency Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, China. 4. Laboratory Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. 5. Global Health Research Center, Duke Kunshan University, Kunshan, China. gregory.gray@duke.edu. 6. Division of Infectious Diseases, Duke University, School of Medicine, DUMC Box 102359, Durham, NC, 27710, USA. gregory.gray@duke.edu. 7. Duke Global Health Institute, Duke University, Durham, NC, USA. gregory.gray@duke.edu. 8. Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. gregory.gray@duke.edu. 9. Emergency Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, China. iamliuyuntao@163.com.
Abstract
BACKGROUND: Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). METHODS: To understand the epidemiology and subtype distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV subtypes. RESULTS: HAdV was successfully sequenced in 99 (2.4%) of the 4129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%), and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer. CONCLUSION: All ages suffer adenovirus infections, but young children are at the greatest risk. This study data demonstrates that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.
BACKGROUND: Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). METHODS: To understand the epidemiology and subtype distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV subtypes. RESULTS:HAdV was successfully sequenced in 99 (2.4%) of the 4129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infectedpatients were fever (100%), cough (80.8%), and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer. CONCLUSION: All ages suffer adenovirus infections, but young children are at the greatest risk. This study data demonstrates that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.
Authors: Helena Rebelo-de-Andrade; Cristiana Pereira; Marta Gíria; Ema Prudêncio; Maria João Brito; Etelvina Calé; Nuno Taveira Journal: J Clin Microbiol Date: 2010-02-10 Impact factor: 5.948
Authors: Shellie A Kolavic-Gray; Leonard N Binn; Jose L Sanchez; Steven B Cersovsky; Christina S Polyak; Felicia Mitchell-Raymundo; Ludmila V Asher; David W Vaughn; Brian H Feighner; Bruce L Innis Journal: Clin Infect Dis Date: 2002-09-10 Impact factor: 9.079
Authors: Akshay Dhingra; Elias Hage; Tina Ganzenmueller; Sindy Böttcher; Jörg Hofmann; Klaus Hamprecht; Patrick Obermeier; Barbara Rath; Fabian Hausmann; Thomas Dobner; Albert Heim Journal: Sci Rep Date: 2019-01-31 Impact factor: 4.379