Maria I Argyropoulou1, Vasileios G Xydis2, Aikaterini Drougia3, Anastasia S Giantsouli2, Vasileios Giapros3, Loukas G Astrakas4. 1. Department of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece. margyrop@uoi.gr. 2. Department of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece. 3. Neonatal Intensive Care Unit, Child Health Department, Faculty of Medicine, University of Ioannina, Ioannina, Greece. 4. Department of Medical Physics, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Abstract
PURPOSE: Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on brain structural connectivity (SC) and FC. METHODS: Babies born MLPT between January 2014 and May 2017 underwent brain ultrasound (US) at 72 h and 7 days after birth, and MRI at around term equivalent. The MRI protocol comprised T1- and T2-weighted sequences, diffusion tensor imaging (DTI), and resting-state functional MRI (fMRI). SC and FC were assessed using graph analysis. RESULTS: Of 350 MLPT neonates, 15 showed low-grade IVH on US at 72 h, for which brain MRI was available in 10. These 10 infants, with mean gestational age (GA) 34.0 ± 0.8 weeks, comprised the study group, and 10 MLPT infants of mean GA 33.9 ± 1.1 weeks, with no abnormalities on brain US and MRI, were control subjects. All study subjects presented modularity, small world topology, and rich club organization for both SC and FC. The patients with low-grade IVH had lower FC rich club coefficient and lower SC betweenness centrality in the left frontoparietal operculum, and lower SC rich club coefficient in the right superior orbitofrontal cortex than the control subjects. CONCLUSIONS: Topological and functional properties of mature brain connectivity are present in MLPT infants. IVH in these infants was associated with structural and functional abnormalities in the left frontoparietal operculum and right orbitofrontal cortex, regions related to language and cognition.
PURPOSE: Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on brain structural connectivity (SC) and FC. METHODS: Babies born MLPT between January 2014 and May 2017 underwent brain ultrasound (US) at 72 h and 7 days after birth, and MRI at around term equivalent. The MRI protocol comprised T1- and T2-weighted sequences, diffusion tensor imaging (DTI), and resting-state functional MRI (fMRI). SC and FC were assessed using graph analysis. RESULTS: Of 350 MLPT neonates, 15 showed low-grade IVH on US at 72 h, for which brain MRI was available in 10. These 10 infants, with mean gestational age (GA) 34.0 ± 0.8 weeks, comprised the study group, and 10 MLPT infants of mean GA 33.9 ± 1.1 weeks, with no abnormalities on brain US and MRI, were control subjects. All study subjects presented modularity, small world topology, and rich club organization for both SC and FC. The patients with low-grade IVH had lower FC rich club coefficient and lower SC betweenness centrality in the left frontoparietal operculum, and lower SC rich club coefficient in the right superior orbitofrontal cortex than the control subjects. CONCLUSIONS: Topological and functional properties of mature brain connectivity are present in MLPT infants. IVH in these infants was associated with structural and functional abnormalities in the left frontoparietal operculum and right orbitofrontal cortex, regions related to language and cognition.
Authors: Jeanie L Cheong; Lex W Doyle; Alice C Burnett; Katherine J Lee; Jennifer M Walsh; Cody R Potter; Karli Treyvaud; Deanne K Thompson; Joy E Olsen; Peter J Anderson; Alicia J Spittle Journal: JAMA Pediatr Date: 2017-04-03 Impact factor: 16.193
Authors: M I Argyropoulou; L G Astrakas; V G Xydis; A Drougia; V Mouka; I Goel; V Giapros; S Andronikou Journal: AJNR Am J Neuroradiol Date: 2020-02-13 Impact factor: 3.825
Authors: Claire E Kelly; Jeanie L Y Cheong; Lillian Gabra Fam; Alexander Leemans; Marc L Seal; Lex W Doyle; Peter J Anderson; Alicia J Spittle; Deanne K Thompson Journal: Brain Imaging Behav Date: 2016-03 Impact factor: 3.978
Authors: Andrew J Degnan; Jessica L Wisnowski; SoYoung Choi; Rafael Ceschin; Chitresh Bhushan; Richard M Leahy; Patricia Corby; Vincent J Schmithorst; Ashok Panigrahy Journal: PLoS One Date: 2015-06-22 Impact factor: 3.240