Literature DB >> 34341531

Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids.

Kevin G Chen1, Kyeyoon Park2, Jason R Spence3,4,5.   

Abstract

Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

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Year:  2021        PMID： 34341531      PMCID： PMC8355201          DOI： 10.1038/s41556-021-00721-x

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  137 in total

Review 1.  Organoids as an in vitro model of human development and disease.

Authors:  Aliya Fatehullah; Si Hui Tan; Nick Barker
Journal:  Nat Cell Biol       Date:  2016-03       Impact factor: 28.824

Review 2.  Organogenesis in a dish: modeling development and disease using organoid technologies.

Authors:  Madeline A Lancaster; Juergen A Knoblich
Journal:  Science       Date:  2014-07-17       Impact factor: 47.728

Review 3.  Pluripotent Stem Cell Platforms for Drug Discovery.

Authors:  Kevin G Chen; Barbara S Mallon; Kyeyoon Park; Pamela G Robey; Ronald D G McKay; Michael M Gottesman; Wei Zheng
Journal:  Trends Mol Med       Date:  2018-07-11       Impact factor: 11.951

Review 4.  Modeling Development and Disease with Organoids.

Authors:  Hans Clevers
Journal:  Cell       Date:  2016-06-16       Impact factor: 41.582

5.  Genetic mechanisms of critical illness in COVID-19.

Authors:  Erola Pairo-Castineira; Sara Clohisey; Lucija Klaric; Andrew D Bretherick; Konrad Rawlik; Dorota Pasko; Susan Walker; Nick Parkinson; Max Head Fourman; Clark D Russell; James Furniss; Anne Richmond; Elvina Gountouna; Nicola Wrobel; David Harrison; Bo Wang; Yang Wu; Alison Meynert; Fiona Griffiths; Wilna Oosthuyzen; Athanasios Kousathanas; Loukas Moutsianas; Zhijian Yang; Ranran Zhai; Chenqing Zheng; Graeme Grimes; Rupert Beale; Jonathan Millar; Barbara Shih; Sean Keating; Marie Zechner; Chris Haley; David J Porteous; Caroline Hayward; Jian Yang; Julian Knight; Charlotte Summers; Manu Shankar-Hari; Paul Klenerman; Lance Turtle; Antonia Ho; Shona C Moore; Charles Hinds; Peter Horby; Alistair Nichol; David Maslove; Lowell Ling; Danny McAuley; Hugh Montgomery; Timothy Walsh; Alexandre C Pereira; Alessandra Renieri; Xia Shen; Chris P Ponting; Angie Fawkes; Albert Tenesa; Mark Caulfield; Richard Scott; Kathy Rowan; Lee Murphy; Peter J M Openshaw; Malcolm G Semple; Andrew Law; Veronique Vitart; James F Wilson; J Kenneth Baillie
Journal:  Nature       Date:  2020-12-11       Impact factor: 69.504

6.  SARS-CoV-2 productively infects human gut enterocytes.

Authors:  Mart M Lamers; Joep Beumer; Jelte van der Vaart; Bart L Haagmans; Hans Clevers; Kèvin Knoops; Jens Puschhof; Tim I Breugem; Raimond B G Ravelli; J Paul van Schayck; Anna Z Mykytyn; Hans Q Duimel; Elly van Donselaar; Samra Riesebosch; Helma J H Kuijpers; Debby Schipper; Willine J van de Wetering; Miranda de Graaf; Marion Koopmans; Edwin Cuppen; Peter J Peters
Journal:  Science       Date:  2020-05-01       Impact factor: 47.728

7.  Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

Authors:  Vanessa Monteil; Hyesoo Kwon; Patricia Prado; Astrid Hagelkrüys; Reiner A Wimmer; Martin Stahl; Alexandra Leopoldi; Elena Garreta; Carmen Hurtado Del Pozo; Felipe Prosper; Juan Pablo Romero; Gerald Wirnsberger; Haibo Zhang; Arthur S Slutsky; Ryan Conder; Nuria Montserrat; Ali Mirazimi; Josef M Penninger
Journal:  Cell       Date:  2020-04-24       Impact factor: 41.582

8.  Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.

Authors:  Fadi Jacob; Sarshan R Pather; Wei-Kai Huang; Feng Zhang; Samuel Zheng Hao Wong; Haowen Zhou; Beatrice Cubitt; Wenqiang Fan; Catherine Z Chen; Miao Xu; Manisha Pradhan; Daniel Y Zhang; Wei Zheng; Anne G Bang; Hongjun Song; Juan Carlos de la Torre; Guo-Li Ming
Journal:  Cell Stem Cell       Date:  2020-09-21       Impact factor: 24.633

9.  Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.

Authors:  Yuling Han; Xiaohua Duan; Liuliu Yang; Benjamin E Nilsson-Payant; Pengfei Wang; Fuyu Duan; Xuming Tang; Tomer M Yaron; Tuo Zhang; Skyler Uhl; Yaron Bram; Chanel Richardson; Jiajun Zhu; Zeping Zhao; David Redmond; Sean Houghton; Duc-Huy T Nguyen; Dong Xu; Xing Wang; Jose Jessurun; Alain Borczuk; Yaoxing Huang; Jared L Johnson; Yuru Liu; Jenny Xiang; Hui Wang; Lewis C Cantley; Benjamin R tenOever; David D Ho; Fong Cheng Pan; Todd Evans; Huanhuan Joyce Chen; Robert E Schwartz; Shuibing Chen
Journal:  Nature       Date:  2020-10-28       Impact factor: 49.962

10.  Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Authors:  Hiroaki Katsura; Vishwaraj Sontake; Aleksandra Tata; Yoshihiko Kobayashi; Caitlin E Edwards; Brook E Heaton; Arvind Konkimalla; Takanori Asakura; Yu Mikami; Ethan J Fritch; Patty J Lee; Nicholas S Heaton; Richard C Boucher; Scott H Randell; Ralph S Baric; Purushothama Rao Tata
Journal:  Cell Stem Cell       Date:  2020-10-21       Impact factor: 25.269
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  3 in total

Review 1.  Implications of testicular ACE2 and the renin-angiotensin system for SARS-CoV-2 on testis function.

Authors:  R Clayton Edenfield; Charles A Easley
Journal:  Nat Rev Urol       Date:  2021-11-26       Impact factor: 16.430

2.  Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived Cardiomyocytes.

Authors:  Xiaochen Huang; Boxin Huang; Yong He; Liang Feng; Jian Shi; Li Wang; Juan Peng; Yong Chen
Journal:  Adv Biol (Weinh)       Date:  2022-05-06

Review 3.  Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID-19 and response to treatment.

Authors:  Richard J Head; Eugenie R Lumbers; Bevyn Jarrott; Felix Tretter; Gary Smith; Kirsty G Pringle; Saiful Islam; Jennifer H Martin
Journal:  Pharmacol Res Perspect       Date:  2022-02
  3 in total

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