Literature DB >> 34333687

The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems.

Albert J Ksinan1,2, Rebecca L Smith3, Peter B Barr3, Alexander T Vazsonyi4.   

Abstract

The current study focused on longitudinal effects of genetics and parental behaviors and their interplay on externalizing behaviors in a panel study following individuals from adolescence to young adulthood. The nationally representative sample of Add Health participants of European ancestry included N = 4142 individuals, measured on three occasions. Parenting was operationalized as experiences with child maltreatment and maternal closeness. Externalizing problems were operationalized as alcohol use, cannabis use, and antisocial behaviors. Genetic effects were operationalized as a polygenic score (PGS) of risky behaviors. The results showed significant effects for child maltreatment, maternal closeness, and PGS, above and beyond other factors and previous levels of externalizing behaviors. Furthermore, maternal closeness was found to negatively correlate with PGS. No significant interaction effects of parenting and PGS were found. The results underscore the joint independent effects of parenting and genetics on the change in externalizing behaviors from adolescence to young adulthood.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Externalizing behavior; Parenting; Polygenic score; Risky behaviors; Substance use

Mesh：

Year:  2021        PMID： 34333687      PMCID： PMC8836487          DOI： 10.1007/s10519-021-10079-3

Source DB:  PubMed          Journal:  Behav Genet        ISSN： 0001-8244            Impact factor:   2.805


  68 in total

1.  Gene - Environment Interplay, Family Relationships, and Child Adjustment.

Authors:  Briana N Horwitz; Jenae M Neiderhiser
Journal:  J Marriage Fam       Date:  2011-08-01

2.  Developmental trajectories of substance use from early adolescence to young adulthood: gender and racial/ethnic differences.

Authors:  Pan Chen; Kristen C Jacobson
Journal:  J Adolesc Health       Date:  2011-07-13       Impact factor: 5.012

3.  Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.

Authors:  Jessica E Salvatore; Fazil Aliev; Kathleen Bucholz; Arpana Agrawal; Victor Hesselbrock; Michie Hesselbrock; Lance Bauer; Samuel Kuperman; Marc A Schuckit; John Kramer; Howard J Edenberg; Tatiana M Foroud; Danielle M Dick
Journal:  Clin Psychol Sci       Date:  2015-03

4.  Parenting and Child Externalizing Behaviors: Are the Associations Specific or Diffuse?

Authors:  Laura McKee; Christina Colletti; Aaron Rakow; Deborah J Jones; Rex Forehand
Journal:  Aggress Violent Behav       Date:  2008

5.  Using dimensional models of externalizing psychopathology to aid in gene identification.

Authors:  Danielle M Dick; Fazil Aliev; Jen C Wang; Richard A Grucza; Marc Schuckit; Samuel Kuperman; John Kramer; Anthony Hinrichs; Sarah Bertelsen; John P Budde; Victor Hesselbrock; Bernice Porjesz; Howard J Edenberg; Laura Jean Bierut; Alison Goate
Journal:  Arch Gen Psychiatry       Date:  2008-03

6.  Early physical abuse and later violent delinquency: a prospective longitudinal study.

Authors:  Jennifer E Lansford; Shari Miller-Johnson; Lisa J Berlin; Kenneth A Dodge; John E Bates; Gregory S Pettit
Journal:  Child Maltreat       Date:  2007-08

7.  Exploring the relationship between polygenic risk for cannabis use, peer cannabis use and the longitudinal course of cannabis involvement.

Authors:  Emma C Johnson; Rebecca Tillman; Fazil Aliev; Jacquelyn L Meyers; Jessica E Salvatore; Andrey P Anokhin; Danielle M Dick; Howard J Edenberg; John R Kramer; Samuel Kuperman; Vivia V McCutcheon; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Jay Tischfield; Kathleen K Bucholz; Arpana Agrawal
Journal:  Addiction       Date:  2019-01-01       Impact factor: 7.256

Review 8.  Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Authors:  Daniel John Lawson; Neil Martin Davies; Simon Haworth; Bilal Ashraf; Laurence Howe; Andrew Crawford; Gibran Hemani; George Davey Smith; Nicholas John Timpson
Journal:  Hum Genet       Date:  2019-04-27       Impact factor: 4.132

9.  A reference panel of 64,976 haplotypes for genotype imputation.

Authors:  Shane McCarthy; Sayantan Das; Warren Kretzschmar; Olivier Delaneau; Andrew R Wood; Alexander Teumer; Hyun Min Kang; Christian Fuchsberger; Petr Danecek; Kevin Sharp; Yang Luo; Carlo Sidore; Alan Kwong; Nicholas Timpson; Seppo Koskinen; Scott Vrieze; Laura J Scott; He Zhang; Anubha Mahajan; Jan Veldink; Ulrike Peters; Carlos Pato; Cornelia M van Duijn; Christopher E Gillies; Ilaria Gandin; Massimo Mezzavilla; Arthur Gilly; Massimiliano Cocca; Michela Traglia; Andrea Angius; Jeffrey C Barrett; Dorrett Boomsma; Kari Branham; Gerome Breen; Chad M Brummett; Fabio Busonero; Harry Campbell; Andrew Chan; Sai Chen; Emily Chew; Francis S Collins; Laura J Corbin; George Davey Smith; George Dedoussis; Marcus Dorr; Aliki-Eleni Farmaki; Luigi Ferrucci; Lukas Forer; Ross M Fraser; Stacey Gabriel; Shawn Levy; Leif Groop; Tabitha Harrison; Andrew Hattersley; Oddgeir L Holmen; Kristian Hveem; Matthias Kretzler; James C Lee; Matt McGue; Thomas Meitinger; David Melzer; Josine L Min; Karen L Mohlke; John B Vincent; Matthias Nauck; Deborah Nickerson; Aarno Palotie; Michele Pato; Nicola Pirastu; Melvin McInnis; J Brent Richards; Cinzia Sala; Veikko Salomaa; David Schlessinger; Sebastian Schoenherr; P Eline Slagboom; Kerrin Small; Timothy Spector; Dwight Stambolian; Marcus Tuke; Jaakko Tuomilehto; Leonard H Van den Berg; Wouter Van Rheenen; Uwe Volker; Cisca Wijmenga; Daniela Toniolo; Eleftheria Zeggini; Paolo Gasparini; Matthew G Sampson; James F Wilson; Timothy Frayling; Paul I W de Bakker; Morris A Swertz; Steven McCarroll; Charles Kooperberg; Annelot Dekker; David Altshuler; Cristen Willer; William Iacono; Samuli Ripatti; Nicole Soranzo; Klaudia Walter; Anand Swaroop; Francesco Cucca; Carl A Anderson; Richard M Myers; Michael Boehnke; Mark I McCarthy; Richard Durbin
Journal:  Nat Genet       Date:  2016-08-22       Impact factor: 38.330

Review 10.  The genetics of alcohol and other drug dependence.

Authors:  Danielle M Dick; Arpana Agrawal
Journal:  Alcohol Res Health       Date:  2008
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