| Literature DB >> 34327605 |
Benjamin Matthew Craig1, Kim Rand2,3, John D Hartman4.
Abstract
BACKGROUND: Stated preference research currently lacks a form of evidence that is well suited for small samples. A preference path is a sequence of two or more choices showing the evolution of an object following an adaptive process.Entities:
Mesh:
Year: 2021 PMID: 34327605 PMCID: PMC8321769 DOI: 10.1007/s40271-021-00541-z
Source DB: PubMed Journal: Patient ISSN: 1178-1653 Impact factor: 3.481
Fig. 1.Example of a kaizen task and a preference path
Main effects for the conditional logit and Zermelo–Bradley–Terry (ZBT) specifications
| Conditional logita | ZBT | |||
|---|---|---|---|---|
| QALY loss (95% CI) | QALY loss (95% CI) | |||
| MO1 | 0.001 (− 0.024, 0.018) | 0.990 | 0.001 (0.000, 0.002) | < 0.001 |
| MO2 | 0.068 (0.051, 0.083) | < 0.001 | 0.009 (0.002, 0.018) | < 0.001 |
| MO3 | 0.116 (0.094, 0.142) | < 0.001 | 0.052 (0.019, 0.100) | < 0.001 |
| MO4 | 0.147 (0.123, 0.177) | < 0.001 | 0.160 (0.076, 0.284) | < 0.001 |
| SC1 | 0.000 | NA | 0.001 (0.000, 0.002) | < 0.001 |
| SC2 | 0.064 (0.047, 0.085) | < 0.001 | 0.008 (0.002, 0.019) | < 0.001 |
| SC3 | 0.112 (0.092, 0.139) | < 0.001 | 0.045 (0.019, 0.078) | < 0.001 |
| SC4 | 0.135 (0.110, 0.172) | < 0.001 | 0.102 (0.043, 0.212) | < 0.001 |
| UA1 | 0.010 (− 0.008, 0.025) | 0.300 | 0.001 (0.000, 0.002) | < 0.001 |
| UA2 | 0.083 (0.064, 0.102) | < 0.001 | 0.016 (0.005, 0.030) | < 0.001 |
| UA3 | 0.130 (0.107, 0.159) | < 0.001 | 0.086 (0.039, 0.147) | < 0.001 |
| UA4 | 0.157 (0.128, 0.196) | < 0.001 | 0.228 (0.107, 0.406) | < 0.001 |
| PD1 | 0.014 (− 0.012, 0.033) | 0.228 | 0.001 (0.000, 0.003) | < 0.001 |
| PD2 | 0.098 (0.071, 0.123) | < 0.001 | 0.026 (0.009, 0.048) | < 0.001 |
| PD3 | 0.164 (0.128, 0.213) | < 0.001 | 0.304 (0.110, 0.726) | < 0.001 |
| PD4 | 0.192 (0.151, 0.255) | < 0.001 | 0.777 (0.322, 2.216) | < 0.001 |
| AD1 | 0.014 (− 0.019, 0.038) | 0.328 | 0.001 (0.000, 0.003) | < 0.001 |
| AD2 | 0.091 (0.061, 0.116) | < 0.001 | 0.021 (0.007, 0.038) | < 0.001 |
| AD3 | 0.155 (0.122, 0.195) | < 0.001 | 0.214 (0.080, 0.452) | < 0.001 |
| AD4 | 0.173 (0.139, 0.219) | < 0.001 | 0.425 (0.191, 1.048) | < 0.001 |
For example, the worst EQ-5D-5L profile (55555) is − 0.920 QALYs or − 1.478 QALYs, respectively. Each value is one minus the sum of the 20 estimates of QALY losses
AD Anxiety/Depression, CI confidence interval, MO Mobility, PD Pain/Discomfort, QALY quality-adjusted life year, SC Self-Care, UA Usual Activities
aThe logit scale parameter is significantly greater in the paired comparisons (3.567; 95% CI 2.589–5.276) than the preference path (34.945; 95% CI 26.242–49.986)
Fig. 2Main effects of the conditional logit and Zermelo-Bradley-Terry (ZBT) specifications. Each of the 20 main effects are shown on a quality-adjusted life year (QALY) scale; however, the x-axis was logged to better illustrate the log-linear relationship between the logit and ZBT estimates
Fig. 3Two-column format of a kaizen task [25]
Fig. 4Grid format of a kaizen task
| Eliciting a sequence of preferences along a pathway offers a novel approach for stated-preference researchers, particularly when faced with small samples. |
| This study demonstrates how to implement this adaptive task and estimate 20 main effects using preference evidence collected from 20 respondents during 15-min interview surveys. |
| Its results show that the estimates produced using the Zermelo–Bradley–Terry (ZBT) and logit models have a log-linear relationship. Unlike the logit, the ZBT estimates do not require scaling parameters or additional constraints, which is particularly advantageous in health valuation. |