Nicolás Ramírez1, Gustavo Estofán2, Andrea Tissera3, Rosa Molina3, Eugenia Mercedes Luque1, Pedro Javier Torres1, Arnaldo Mangeaud4, Ana Carolina Martini5. 1. Instituto de Fisiología, Facultad de Ciencias Médicas (FCM), Universidad Nacional de Córdoba and Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)-FCM, Santa Rosa 1085, X5000ESU, Córdoba, Argentina. 2. Centro Integral de Ginecología, Obstetricia y Reproducción (CIGOR), Chacabuco 1123, X5000IIL, Córdoba, Argentina. 3. Laboratorio de Andrología y Reproducción (LAR), Chacabuco 1089, X5000IIK, Córdoba, Argentina. 4. Cátedra de Bioestadística, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Vélez Sarsfield 299, 5000, Córdoba, Argentina. 5. Instituto de Fisiología, Facultad de Ciencias Médicas (FCM), Universidad Nacional de Córdoba and Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)-FCM, Santa Rosa 1085, X5000ESU, Córdoba, Argentina. acmartini2000@fcm.unc.edu.ar.
Abstract
PURPOSE: To evaluate if age, alcohol consumption, and body mass index (BMI) have synergistic effects on seminal quality, and to rank these factors based on their impact on semen. METHODS: Retrospective study of 9464 patients attending an andrology laboratory. Data on patients' age and daily alcohol intake were provided by the patients. BMI was recorded in the laboratory. Seminal parameters evaluated were volume, sperm concentration and total count, motility, morphology, viability, nuclear maturity, and membrane functional integrity. RESULTS: All the seminal parameters evaluated were affected by the synergistic interaction Age x BMI, suggesting that this combination is more potent in affecting semen quality. The variables sperm morphology and nuclear maturity seemed to be especially susceptible since they were affected by the three synergistic interactions. In the logistic regression analysis, age was the most powerful factor since it impacted first on five of the nine parameters, impacting mainly on sperm motility, viability, and morphology, with no effects on sperm count. On the contrary, BMI impacted first in sperm concentration and total sperm count; which was confirmed also by the logistic predictions analysis. Alcohol consumption impacted first on membrane functional integrity and nuclear maturity. A J-shaped association between BMI or alcohol consumption with semen quality was found in the multivariate analysis. CONCLUSION: The factors considered in this study showed a synergistic negative impact on semen quality, being age and unhealthy weight the most important ones. Reducing the exposure to lifestyle risk factors may be promising for improving sperm quality in infertile patients.
PURPOSE: To evaluate if age, alcohol consumption, and body mass index (BMI) have synergistic effects on seminal quality, and to rank these factors based on their impact on semen. METHODS: Retrospective study of 9464 patients attending an andrology laboratory. Data on patients' age and daily alcohol intake were provided by the patients. BMI was recorded in the laboratory. Seminal parameters evaluated were volume, sperm concentration and total count, motility, morphology, viability, nuclear maturity, and membrane functional integrity. RESULTS: All the seminal parameters evaluated were affected by the synergistic interaction Age x BMI, suggesting that this combination is more potent in affecting semen quality. The variables sperm morphology and nuclear maturity seemed to be especially susceptible since they were affected by the three synergistic interactions. In the logistic regression analysis, age was the most powerful factor since it impacted first on five of the nine parameters, impacting mainly on sperm motility, viability, and morphology, with no effects on sperm count. On the contrary, BMI impacted first in sperm concentration and total sperm count; which was confirmed also by the logistic predictions analysis. Alcohol consumption impacted first on membrane functional integrity and nuclear maturity. A J-shaped association between BMI or alcohol consumption with semen quality was found in the multivariate analysis. CONCLUSION: The factors considered in this study showed a synergistic negative impact on semen quality, being age and unhealthy weight the most important ones. Reducing the exposure to lifestyle risk factors may be promising for improving sperm quality in infertile patients.
Authors: Rosa Isabel Molina; Ana Carolina Martini; Andrea Tissera; José Olmedo; Daniel Senestrari; Marta Fiol de Cuneo; Rubén Daniel Ruiz Journal: Arch Esp Urol Date: 2010-04 Impact factor: 0.436
Authors: G Anifandis; T Bounartzi; C I Messini; K Dafopoulos; S Sotiriou; I E Messinis Journal: Arch Gynecol Obstet Date: 2014-05-20 Impact factor: 2.344
Authors: N Sermondade; C Faure; L Fezeu; A G Shayeb; J P Bonde; T K Jensen; M Van Wely; J Cao; A C Martini; M Eskandar; J E Chavarro; S Koloszar; J M Twigt; C H Ramlau-Hansen; E Borges; F Lotti; R P M Steegers-Theunissen; B Zorn; A J Polotsky; S La Vignera; B Eskenazi; K Tremellen; E V Magnusdottir; I Fejes; S Hercberg; R Lévy; S Czernichow Journal: Hum Reprod Update Date: 2012-12-12 Impact factor: 15.610
Authors: J B A Oliveira; C G Petersen; A L Mauri; L D Vagnini; A Renzi; B Petersen; M Mattila; F Dieamant; R L R Baruffi; J G Franco Journal: Andrologia Date: 2017-08-30 Impact factor: 2.775
Authors: Tina Kold Jensen; Shanna Swan; Niels Jørgensen; Jorma Toppari; Bruce Redmon; Margus Punab; Erma Z Drobnis; Trine Berit Haugen; Birute Zilaitiene; Amy E Sparks; D Stewart Irvine; Christina Wang; Pierre Jouannet; Charlene Brazil; Uwe Paasch; Andrea Salzbrunn; Niels Erik Skakkebæk; Anna-Maria Andersson Journal: Hum Reprod Date: 2014-06-03 Impact factor: 6.918
Authors: E M Luque; A Tissera; M P Gaggino; R I Molina; A Mangeaud; L M Vincenti; F Beltramone; J Sad Larcher; D Estofán; M Fiol de Cuneo; A C Martini Journal: Reprod Fertil Dev Date: 2017-04 Impact factor: 2.311
Authors: Nicolás David Ramírez; Andrea Tissera; Rosa Molina; Pablo Gaggino; Arnaldo Mangeaud; Ana Carolina Martini Journal: J Assist Reprod Genet Date: 2022-03-17 Impact factor: 3.357