Tarek Owaidah1,2, Mahasen Saleh3, Amelita M Aguilos1, Abdulllah Al Amri1, Khalid Maghrabi4, Mustafa Owaidah2, Khawar Siddiqui3, Khalid Alsaleh5, Randa Alnounou1. 1. Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA. 2. Alfaisal University Riyadh 11533, KSA. 3. Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA. 4. Department of Critical Care, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA. 5. Department of Medicine, College of Medicine, King Saud University Riyadh 12372, KSA.
Abstract
BACKGROUND: Procoagulant profile of 2019-nCoV/SARS-CoV-2 has been well documented over the last year. Perturbance in coagulating factors has also been reported in Covid-19 patients, including increased d-dimers and reports of lupus anticoagulant (LA). METHODS: The current study aimed to identify the incidence of positivity of lupus anticoagulant in Covid-19 patients and analyze the association between LA and D-dimer in predicting thrombosis and mortality in one-hundred and five hospitalized adult (age >14 years) patients and forty-three hospitalized pediatric (age <14 years) patients with a confirmed diagnosis of Covid-19 between June 2020 and September 2020. RESULTS: Twenty-one (20%) adult patients were tested positive for PTT LA, of which nine (8.6%) turned out to be confirmed positive for LA through StaClot and DRVVT Ratio tests. Six (14%) pediatric patients were positive for PTT LA, and only one (2.3%) had positive StaClot. Median D-dimer at admission was positively correlated with age and CRP among adult patients and was significantly higher in expired cases (P=0.001). No association between any of the coagulation tests and thrombosis or mortality was observed in the pediatric cohort. CONCLUSION: We report an increased incidence of LA in Covid-19 patients, yet we didn't find any association between thrombotic events or mortality, probably due to the small sample size. AJBR
BACKGROUND: Procoagulant profile of 2019-nCoV/SARS-CoV-2 has been well documented over the last year. Perturbance in coagulating factors has also been reported in Covid-19patients, including increased d-dimers and reports of lupus anticoagulant (LA). METHODS: The current study aimed to identify the incidence of positivity of lupus anticoagulant in Covid-19patients and analyze the association between LA and D-dimer in predicting thrombosis and mortality in one-hundred and five hospitalized adult (age >14 years) patients and forty-three hospitalized pediatric (age <14 years) patients with a confirmed diagnosis of Covid-19 between June 2020 and September 2020. RESULTS: Twenty-one (20%) adult patients were tested positive for PTT LA, of which nine (8.6%) turned out to be confirmed positive for LA through StaClot and DRVVT Ratio tests. Six (14%) pediatric patients were positive for PTT LA, and only one (2.3%) had positive StaClot. Median D-dimer at admission was positively correlated with age and CRP among adult patients and was significantly higher in expired cases (P=0.001). No association between any of the coagulation tests and thrombosis or mortality was observed in the pediatric cohort. CONCLUSION: We report an increased incidence of LA in Covid-19patients, yet we didn't find any association between thrombotic events or mortality, probably due to the small sample size. AJBR
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