Harsha L Rao1, Srilakshmi Dasari2, Narendra K Puttaiah2, Zia S Pradhan3, Sasan Moghimi4, Kaweh Mansouri5, Carroll A B Webers6, Robert N Weinreb4. 1. From Narayana Nethralaya (H.L.R., S.D., N.K.P.), Hulimavu, Bangalore, India; University Eye Clinic Maastricht (H.L.R., C.A.B.W), University Medical Center, Maastricht, the Netherlands. Electronic address: harshalaxmanarao@gmail.com. 2. From Narayana Nethralaya (H.L.R., S.D., N.K.P.), Hulimavu, Bangalore, India. 3. Narayana Nethralaya (Z.S.P.), Rajajinagar, Bangalore, India. 4. Hamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology (S.M., R.N.W.), University of California, San Diego, La Jolla, California, USA. 5. Glaucoma Research Center (K.M.), Montchoisi Clinic, Swiss Visio, Lausanne, Switzerland; Department of Ophthalmology (K.M.), University of Colorado, Denver, Colorado, USA. 6. University Eye Clinic Maastricht (H.L.R., C.A.B.W), University Medical Center, Maastricht, the Netherlands.
Abstract
PURPOSE: To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). DESIGN: Prospective case series. METHODS: Sixty-four eyes of 40 patients with POAG (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, sex, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, and mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation, baseline quadrant optical coherence tomography RNFL and ganglion cell inner plexiform layer thickness), and OMAG (peripapillary and macular perfusion density [PD] and vessel density [VD]) on the rate of RNFL change was evaluated using linear mixed models. RESULTS: Average (±SD) mean deviation, RNFL, and ganglion cell inner plexiform layer thickness of the analyzed quadrants at baseline were -5.5 ± 2.9 dB, 96.5 ± 17.9 µm, and 73.8 ± 8.6 µm, respectively. Peripapillary PD and VD in the quadrant were 44.6% ± 5.9% and 17.5 ± 2.2 mm/mm2, respectively. Rate of quadrant RNFL change was -1.8 ± 0.6 µm/y. Multivariate mixed models showed that lower peripapillary PD (coefficient = 0.08, P = .01) and lower VD (coefficient = 0.21, P = .02) were significantly associated with a faster rate of RNFL loss. CONCLUSIONS: Lower baseline peripapillary PD and VD measured using OMAG were significantly associated with a faster rate of RNFL loss in POAG. OMAG imaging provides useful information about the risk of glaucoma progression and the rate of disease worsening.
PURPOSE: To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). DESIGN: Prospective case series. METHODS: Sixty-four eyes of 40 patients with POAG (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, sex, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, and mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation, baseline quadrant optical coherence tomography RNFL and ganglion cell inner plexiform layer thickness), and OMAG (peripapillary and macular perfusion density [PD] and vessel density [VD]) on the rate of RNFL change was evaluated using linear mixed models. RESULTS: Average (±SD) mean deviation, RNFL, and ganglion cell inner plexiform layer thickness of the analyzed quadrants at baseline were -5.5 ± 2.9 dB, 96.5 ± 17.9 µm, and 73.8 ± 8.6 µm, respectively. Peripapillary PD and VD in the quadrant were 44.6% ± 5.9% and 17.5 ± 2.2 mm/mm2, respectively. Rate of quadrant RNFL change was -1.8 ± 0.6 µm/y. Multivariate mixed models showed that lower peripapillary PD (coefficient = 0.08, P = .01) and lower VD (coefficient = 0.21, P = .02) were significantly associated with a faster rate of RNFL loss. CONCLUSIONS: Lower baseline peripapillary PD and VD measured using OMAG were significantly associated with a faster rate of RNFL loss in POAG. OMAG imaging provides useful information about the risk of glaucoma progression and the rate of disease worsening.
Authors: Harsha L Rao; Mohammed Riyazuddin; Srilakshmi Dasari; Narendra K Puttaiah; Zia S Pradhan; Robert N Weinreb; Kaweh Mansouri; Carroll A B Webers Journal: J Glaucoma Date: 2018-03 Impact factor: 2.503
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