| Literature DB >> 34320169 |
Sebastian Kollmann1, Reinhard Grausenburger1, Thorsten Klampfl1, Michaela Prchal-Murphy1, Klavdija Bastl1, Hanja Pisa2, Vanessa M Knab1, Tania Brandstoetter1, Eszter Doma1, Wolfgang R Sperr3,4, Sabine Lagger5, Matthias Farlik6,7, Richard Moriggl8, Peter Valent3,4, Florian Halbritter2, Karoline Kollmann1, Gerwin Heller1,9, Barbara Maurer1, Veronika Sexl1.
Abstract
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions, but we describe a unique role for STAT5B in driving the self-renewal of hematopoietic and leukemic stem cells (HSCs/LSCs). We find STAT5B to be specifically activated in HSCs and LSCs, where it induces many genes associated with quiescence and self-renewal, including the surface marker CD9. Levels of CD9 represent a prognostic marker for patients with STAT5-driven leukemia, and our findings suggest that anti-CD9 antibodies may be useful in their treatment to target and eliminate LSCs. We show that it is vital to consider STAT5A and STAT5B as distinct entities in normal and malignant hematopoiesis.Entities:
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Year: 2021 PMID： 34320169 PMCID： PMC8777465 DOI： 10.1182/blood.2021010980
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113