OBJECTIVE: To evaluate, through a systematic review (SR) with meta-analysis, the occurrence of genotoxic effects in the oral epithelium after the exposure of patients to panoramic radiographs. METHODS: An SR was performed with the PICOS (Population, Intervention, Comparison, Outcome, and Study design) strategy, aiming to answer the following question: "Can panoramic radiographs induce genotoxic effects on the oral epithelium?" The study was registered in the PROSPERO (International prospective register of systematic reviews) platform. A systematic search was performed in the following electronic databases: PubMed (including MedLine), Scopus, Embase, LILACS, Medline EbscoHost, and Google Scholar. Treatment effects were defined as standardized mean difference (SMD), and 95% confidence intervals (CI) were established. The Joanna Briggs Institute questionnaire for observational studies was applied to assess the risk of bias. The GRADE tool was used to assess the quality of evidence of the SR. RESULTS: A total of 251 potentially relevant studies were selected through the search strategy. After screening titles and abstracts, 11 full-text manuscripts were assessed for eligibility and nine observational studies were included in the meta-analysis. The present study showed an increase in micronuclei after the exposure (SMD = 0.21, 95% CI, 0.03 to 0.28, p = 0.02), with a Tau2index = 0.00, Chi2 = 2.35, and p-value = 0.97. Therefore, the articles selected were considered homogeneous and the I² of 0% indicated low heterogeneity. CONCLUSION: According to the studies analysed, although the quality of evidence was considered low, panoramic radiographs can cause genotoxic damage in the oral epithelium but with a small effect size.
OBJECTIVE: To evaluate, through a systematic review (SR) with meta-analysis, the occurrence of genotoxic effects in the oral epithelium after the exposure of patients to panoramic radiographs. METHODS: An SR was performed with the PICOS (Population, Intervention, Comparison, Outcome, and Study design) strategy, aiming to answer the following question: "Can panoramic radiographs induce genotoxic effects on the oral epithelium?" The study was registered in the PROSPERO (International prospective register of systematic reviews) platform. A systematic search was performed in the following electronic databases: PubMed (including MedLine), Scopus, Embase, LILACS, Medline EbscoHost, and Google Scholar. Treatment effects were defined as standardized mean difference (SMD), and 95% confidence intervals (CI) were established. The Joanna Briggs Institute questionnaire for observational studies was applied to assess the risk of bias. The GRADE tool was used to assess the quality of evidence of the SR. RESULTS: A total of 251 potentially relevant studies were selected through the search strategy. After screening titles and abstracts, 11 full-text manuscripts were assessed for eligibility and nine observational studies were included in the meta-analysis. The present study showed an increase in micronuclei after the exposure (SMD = 0.21, 95% CI, 0.03 to 0.28, p = 0.02), with a Tau2index = 0.00, Chi2 = 2.35, and p-value = 0.97. Therefore, the articles selected were considered homogeneous and the I² of 0% indicated low heterogeneity. CONCLUSION: According to the studies analysed, although the quality of evidence was considered low, panoramic radiographs can cause genotoxic damage in the oral epithelium but with a small effect size.
Authors: Gordon Guyatt; Andrew D Oxman; Shahnaz Sultan; Jan Brozek; Paul Glasziou; Pablo Alonso-Coello; David Atkins; Regina Kunz; Victor Montori; Roman Jaeschke; David Rind; Philipp Dahm; Elie A Akl; Joerg Meerpohl; Gunn Vist; Elise Berliner; Susan Norris; Yngve Falck-Ytter; Holger J Schünemann Journal: J Clin Epidemiol Date: 2012-04-27 Impact factor: 6.437
Authors: Howard Balshem; Mark Helfand; Holger J Schünemann; Andrew D Oxman; Regina Kunz; Jan Brozek; Gunn E Vist; Yngve Falck-Ytter; Joerg Meerpohl; Susan Norris; Gordon H Guyatt Journal: J Clin Epidemiol Date: 2011-01-05 Impact factor: 6.437
Authors: E M M Cerqueira; J R C Meireles; M A Lopes; V C Junqueira; I S Gomes-Filho; S Trindade; G M Machado-Santelli Journal: Dentomaxillofac Radiol Date: 2008-10 Impact factor: 2.419
Authors: Gordon H Guyatt; Andrew D Oxman; Gunn Vist; Regina Kunz; Jan Brozek; Pablo Alonso-Coello; Victor Montori; Elie A Akl; Ben Djulbegovic; Yngve Falck-Ytter; Susan L Norris; John W Williams; David Atkins; Joerg Meerpohl; Holger J Schünemann Journal: J Clin Epidemiol Date: 2011-01-19 Impact factor: 6.437
Authors: Gordon H Guyatt; Kristian Thorlund; Andrew D Oxman; Stephen D Walter; Donald Patrick; Toshi A Furukawa; Bradley C Johnston; Paul Karanicolas; Elie A Akl; Gunn Vist; Regina Kunz; Jan Brozek; Lawrence L Kupper; Sandra L Martin; Joerg J Meerpohl; Pablo Alonso-Coello; Robin Christensen; Holger J Schunemann Journal: J Clin Epidemiol Date: 2012-10-30 Impact factor: 6.437
Authors: Marcos Antônio Lima Dos Santos; Francielle Santos de Santana; Andréa Ferreira Soares; Sílvia Ferreira de Sousa; Liciane S Menezes; Wilton Mitsunari Takeshita Journal: Gen Dent Date: 2020 Nov-Dec