OBJECTIVE: To evaluate the genotoxic effects of x-rays on gingival and buccal epithelial cells during panoramic dental radiography using the micronucleus test. METHOD AND MATERIALS: Eighty otherwise healthy subjects who required a diagnostic panoramic radiograph and met the selection criteria were included in the study. Epithelial cells were obtained from the maxillary anterior gingiva and buccal mucosa by gentle scraping with a wooden spatula immediately before exposure and again 10 days after exposure. Cytologic preparations were made according to the Papanicolaou staining method and analyzed under a light microscope for micronucleus count. RESULTS: The mean ± SD micronucleus count of gingival epithelial cells was 1.08 ± 0.76 before radiographic exposure and 1.6 ± 0.93 after exposure. This increase was statistically significant (P < .05). Similarly, there was an increase in the postexposure micronucleus count in the buccal mucosa, but this increase was not significant (P > .05). A significant correlation was observed between the age of subjects and micronucleus count, although no such correlation was found between sex and micronucleus count. CONCLUSION: Although radiation-related effects from panoramic radiography were reduced compared with full-mouth intraoral periapical radiographs or radiotherapy, the results of this study show that genotoxic effects do take place. Thus, radiographs should be taken with adequate protection measures and only when the potential benefit outweighs the potential risk.
OBJECTIVE: To evaluate the genotoxic effects of x-rays on gingival and buccal epithelial cells during panoramic dental radiography using the micronucleus test. METHOD AND MATERIALS: Eighty otherwise healthy subjects who required a diagnostic panoramic radiograph and met the selection criteria were included in the study. Epithelial cells were obtained from the maxillary anterior gingiva and buccal mucosa by gentle scraping with a wooden spatula immediately before exposure and again 10 days after exposure. Cytologic preparations were made according to the Papanicolaou staining method and analyzed under a light microscope for micronucleus count. RESULTS: The mean ± SD micronucleus count of gingival epithelial cells was 1.08 ± 0.76 before radiographic exposure and 1.6 ± 0.93 after exposure. This increase was statistically significant (P < .05). Similarly, there was an increase in the postexposure micronucleus count in the buccal mucosa, but this increase was not significant (P > .05). A significant correlation was observed between the age of subjects and micronucleus count, although no such correlation was found between sex and micronucleus count. CONCLUSION: Although radiation-related effects from panoramic radiography were reduced compared with full-mouth intraoral periapical radiographs or radiotherapy, the results of this study show that genotoxic effects do take place. Thus, radiographs should be taken with adequate protection measures and only when the potential benefit outweighs the potential risk.
Authors: Milena B Silva; Ana P D Demasi; Elizabeth F Martinez; Maristane L Goudinho; Joarlene M Soares; José L C Junqueira; Ney S Araujo Journal: Clin Oral Investig Date: 2017-10-23 Impact factor: 3.573
Authors: Marcos Antônio Lima Dos Santos; Graziane Ribeiro Couto; Mark Jon Santana Sabey; Danilo de Paula Ribeiro Borges; Wilton Mitsunari Takeshita Journal: Dentomaxillofac Radiol Date: 2021-07-28 Impact factor: 2.419
Authors: Niels Belmans; Anne Caroline Oenning; Benjamin Salmon; Bjorn Baselet; Kevin Tabury; Stéphane Lucas; Ivo Lambrichts; Marjan Moreels; Reinhilde Jacobs; Sarah Baatout Journal: Dentomaxillofac Radiol Date: 2021-05-14 Impact factor: 3.525
Authors: Marc A Moll; Miriam Seuthe; Constantin von See; Antonia Zapf; Else Hornecker; Rainer F Mausberg; Dirk Ziebolz Journal: BMC Oral Health Date: 2013-09-26 Impact factor: 2.757