Literature DB >> 34315500

A pancreas tumor derived organoid study: from drug screen to precision medicine.

Jia Yao1, Man Yang2, Lawrence Atteh2, Pinyan Liu2, Yongcui Mao2, Wenbo Meng3, Xun Li4.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, and systemic therapies for PDAC generally lack efficacy. Thus, developing biomarkers for treatment guidance is urgently required. This review focuses on pancreatic tumor organoids (PTOs), which can mimic the characteristics of the original tumor in vitro. As a powerful tool with several applications, PTOs represent a new strategy for targeted therapy in pancreatic cancer and contribute to the advancement of the field of personalized medicine.
© 2021. The Author(s).

Entities:  

Keywords:  Drug screen; Pancreas cancer; Pancreas tumor derived organoids (PTOs); Pancreatic ductal adenocarcinoma (PDAC); Precision medicine

Year:  2021        PMID： 34315500     DOI： 10.1186/s12935-021-02044-1

Source DB:  PubMed          Journal:  Cancer Cell Int        ISSN： 1475-2867            Impact factor:   5.722


  102 in total

Review 1.  Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC).

Authors:  Sreenivasa Chandana; Hani M Babiker; Daruka Mahadevan
Journal:  Expert Opin Investig Drugs       Date:  2018-12-16       Impact factor: 6.206

2.  Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture.

Authors:  Yoko Matsuda; Toshiyuki Ishiwata; Yoko Kawamoto; Kiyoko Kawahara; Wei-Xia Peng; Tetsushi Yamamoto; Zenya Naito
Journal:  Med Mol Morphol       Date:  2011-01-26       Impact factor: 2.309

Review 3.  Pathology of pancreatic ductal adenocarcinoma: facts, challenges and future developments.

Authors:  Irene Esposito; Björn Konukiewitz; Anna Melissa Schlitter; Günter Klöppel
Journal:  World J Gastroenterol       Date:  2014-10-14       Impact factor: 5.742

Review 4.  Pathological and molecular evaluation of pancreatic neoplasms.

Authors:  Arvind Rishi; Michael Goggins; Laura D Wood; Ralph H Hruban
Journal:  Semin Oncol       Date:  2014-12-09       Impact factor: 4.929

5.  3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform.

Authors:  Joseph Candiello; Taraka Sai Pavan Grandhi; Saik Kia Goh; Vimal Vaidya; Maya Lemmon-Kishi; Kiarash Rahmani Eliato; Robert Ros; Prashant N Kumta; Kaushal Rege; Ipsita Banerjee
Journal:  Biomaterials       Date:  2018-05-25       Impact factor: 12.479

Review 6.  Organoid model: A new hope for pancreatic cancer treatment?

Authors:  Haidi Chen; Qifeng Zhuo; Zeng Ye; Xiaowu Xu; Shunrong Ji
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2020-11-04       Impact factor: 10.680

7.  Cancer Statistics, 2021.

Authors:  Rebecca L Siegel; Kimberly D Miller; Hannah E Fuchs; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2021-01-12       Impact factor: 508.702

8.  Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

Authors:  Pascal Belleau; Dannielle D Engle; Hervé Tiriac; Dennis Plenker; Astrid Deschênes; Tim D D Somerville; Fieke E M Froeling; Richard A Burkhart; Robert E Denroche; Gun-Ho Jang; Koji Miyabayashi; C Megan Young; Hardik Patel; Michelle Ma; Joseph F LaComb; Randze Lerie D Palmaira; Ammar A Javed; Jasmine C Huynh; Molly Johnson; Kanika Arora; Nicolas Robine; Minita Shah; Rashesh Sanghvi; Austin B Goetz; Cinthya Y Lowder; Laura Martello; Else Driehuis; Nicolas LeComte; Gokce Askan; Christine A Iacobuzio-Donahue; Hans Clevers; Laura D Wood; Ralph H Hruban; Elizabeth Thompson; Andrew J Aguirre; Brian M Wolpin; Aaron Sasson; Joseph Kim; Maoxin Wu; Juan Carlos Bucobo; Peter Allen; Divyesh V Sejpal; William Nealon; James D Sullivan; Jordan M Winter; Phyllis A Gimotty; Jean L Grem; Dominick J DiMaio; Jonathan M Buscaglia; Paul M Grandgenett; Jonathan R Brody; Michael A Hollingsworth; Grainne M O'Kane; Faiyaz Notta; Edward Kim; James M Crawford; Craig Devoe; Allyson Ocean; Christopher L Wolfgang; Kenneth H Yu; Ellen Li; Christopher R Vakoc; Benjamin Hubert; Sandra E Fischer; Julie M Wilson; Richard Moffitt; Jennifer Knox; Alexander Krasnitz; Steven Gallinger; David A Tuveson
Journal:  Cancer Discov       Date:  2018-05-31       Impact factor: 38.272

9.  Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.

Authors:  Yukihiko Hiroshima; Yong Zhang; Takashi Murakami; Ali Maawy; Shinji Miwa; Mako Yamamoto; Shuya Yano; Sho Sato; Masashi Momiyama; Ryutaro Mori; Ryusei Matsuyama; Takashi Chishima; Kuniya Tanaka; Yasushi Ichikawa; Michael Bouvet; Itaru Endo; Ming Zhao; Robert M Hoffman
Journal:  Oncotarget       Date:  2014-12-15

10.  Mouse pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ.

Authors:  Anja Marciniak; Claudia Selck; Betty Friedrich; Stephan Speier
Journal:  PLoS One       Date:  2013-11-04       Impact factor: 3.240
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  3 in total

Review 1.  Predictive Biomarkers for a Personalized Approach in Resectable Pancreatic Cancer.

Authors:  Valeria Merz; Domenico Mangiameli; Camilla Zecchetto; Alberto Quinzii; Silvia Pietrobono; Carlo Messina; Simona Casalino; Marina Gaule; Camilla Pesoni; Pasquale Vitale; Chiara Trentin; Michela Frisinghelli; Orazio Caffo; Davide Melisi
Journal:  Front Surg       Date:  2022-05-04

2.  Lactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1α pathway and does not affect their drug sensitivities.

Authors:  Zhiwei Wang; Yuanquan Yu; Peiyao Wu; Qinghuang Ye; Yinghao Guo; Xiaoxiao Zhang; Longfu Xi; Qi Li; Yun Jin; Donger Zhou; Yan Luo; Shuyou Peng; Jiangtao Li
Journal:  Cell Death Discov       Date:  2022-04-20

Review 3.  Challenges in genomic analysis of model systems and primary tumors of pancreatic ductal adenocarcinoma.

Authors:  Sangyeop Hyun; Daechan Park
Journal:  Comput Struct Biotechnol J       Date:  2022-09-01       Impact factor: 6.155
  3 in total

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