Literature DB >> 34314360

A Wearable Ultrasonic Neurostimulator - Part I: A 1D CMUT Phased Array System for Chronic Implantation in Small Animals.

Chunkyun Seok, Feysel Yalcin Yamaner, Mesut Sahin, Omer Oralkan.   

Abstract

In this work, we present a wireless ultrasonic neurostimulator, aiming at a truly wearable device for brain stimulation in small behaving animals. A 1D 5-MHz capacitive micromachined ultrasonic transducer (CMUT) array is adopted to implement a head-mounted stimulation device. A companion ASIC with integrated 16-channel high-voltage (60-V) pulsers was designed to drive the 16-element CMUT array. The ASIC can generate excitation signals with element-wise programmable phases and amplitudes: 1) programmable sixteen phase delays enable electrical beam focusing and steering, and 2) four scalable amplitude levels, implemented with a symmetric pulse-width-modulation technique, are sufficient to suppress unwanted sidelobes (apodization). The ASIC was fabricated in the TSMC 0.18- μm HV BCD process within a die size of 2.5 × 2.5 mm2. To realize a completely wearable system, the system is partitioned into two parts for weight distribution: 1) a head unit (17 mg) with the CMUT array, 2) a backpack unit (19.7 g) that includes electronics such as the ASIC, a power management unit, a wireless module, and a battery. Hydrophone-based acoustic measurements were performed to demonstrate the focusing and beam steering capability of the proposed system. Also, we achieved a peak-to-peak pressure of 2.1 MPa, which corresponds to a spatial peak pulse average intensity ( ISPPA) of 33.5 W/cm2, with a lateral full width at half maximum (FWHM) of 0.6 mm at a depth of 3.5 mm.

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Year:  2021        PMID: 34314360      PMCID: PMC9579984          DOI: 10.1109/TBCAS.2021.3100458

Source DB:  PubMed          Journal:  IEEE Trans Biomed Circuits Syst        ISSN: 1932-4545            Impact factor:   5.234


  18 in total

1.  Transcranial pulsed ultrasound stimulates intact brain circuits.

Authors:  Yusuf Tufail; Alexei Matyushov; Nathan Baldwin; Monica L Tauchmann; Joseph Georges; Anna Yoshihiro; Stephen I Helms Tillery; William J Tyler
Journal:  Neuron       Date:  2010-06-10       Impact factor: 17.173

2.  A mm-Sized Free-Floating Wirelessly Powered Implantable Optical Stimulation Device.

Authors:  Yaoyao Jia; S Abdollah Mirbozorgi; Byunghun Lee; Wasif Khan; Fatma Madi; Omer T Inan; Arthur Weber; Wen Li; Maysam Ghovanloo
Journal:  IEEE Trans Biomed Circuits Syst       Date:  2019-05-23       Impact factor: 3.833

3.  Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers.

Authors:  J A Jensen; N B Svendsen
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  1992       Impact factor: 2.725

4.  3-D imaging using row-column-addressed arrays with integrated apodization - part i: apodization design and line element beamforming.

Authors:  Morten Fischer Rasmussen; Thomas Lehrmann Christiansen; Erik Vilain Thomsen; Jørgen Arendt Jensen
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2015-05       Impact factor: 2.725

5.  A three-mask process for fabricating vacuum-sealed capacitive micromachined ultrasonic transducers using anodic bonding.

Authors:  F Yalçın Yamaner; Xiao Zhang; Ömer Oralkan
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2015-05       Impact factor: 2.725

6.  Integrated circuits for volumetric ultrasound imaging with 2-D CMUT arrays.

Authors:  Anshuman Bhuyan; Jung Woo Choe; Byung Chul Lee; Ira O Wygant; Amin Nikoozadeh; Ömer Oralkan; Butrus T Khuri-Yakub
Journal:  IEEE Trans Biomed Circuits Syst       Date:  2013-12       Impact factor: 3.833

7.  A Reduced-Wire ICE Catheter ASIC With Tx Beamforming and Rx Time-Division Multiplexing.

Authors:  Gwangrok Jung; Coskun Tekes; M Wasequr Rashid; Thomas M Carpenter; David Cowell; Steven Freear; F Levent Degertekin; Maysam Ghovanloo
Journal:  IEEE Trans Biomed Circuits Syst       Date:  2018-11-16       Impact factor: 3.833

8.  Frequency Dependence of Ultrasound Neurostimulation in the Mouse Brain.

Authors:  Patrick Peiyong Ye; Julian R Brown; Kim Butts Pauly
Journal:  Ultrasound Med Biol       Date:  2016-04-15       Impact factor: 2.998

9.  Noninvasive Ultrasonic Neuromodulation in Freely Moving Mice.

Authors:  Guofeng Li; Weibao Qiu; Zhiqiang Zhang; Qiuju Jiang; Min Su; Ruilin Cai; Yongchuan Li; Feiyan Cai; Zhiting Deng; Di Xu; Huailing Zhang; Hairong Zheng
Journal:  IEEE Trans Biomed Eng       Date:  2018-04-02       Impact factor: 4.538

10.  Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound.

Authors:  Guo-Feng Li; Hui-Xia Zhao; Hui Zhou; Fei Yan; Jing-Yao Wang; Chang-Xi Xu; Cong-Zhi Wang; Li-Li Niu; Long Meng; Song Wu; Huai-Ling Zhang; Wei-Bao Qiu; Hai-Rong Zheng
Journal:  Sci Rep       Date:  2016-04-20       Impact factor: 4.379

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  2 in total

Review 1.  Circuits on miniaturized ultrasound imaging system-on-a-chip: a review.

Authors:  Jaemyung Lim
Journal:  Biomed Eng Lett       Date:  2022-05-12

Review 2.  Ultrasound stimulation for non-invasive visual prostheses.

Authors:  Jaya Dilip Badadhe; Hyeonhee Roh; Byung Chul Lee; Jae Hun Kim; Maesoon Im
Journal:  Front Cell Neurosci       Date:  2022-08-03       Impact factor: 6.147

  2 in total

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