PURPOSE: Exploration of the effect of chronic recurrent seizures in focal epilepsy on brain volumes has produced many conflicting reports. To determine differences in brain structure in temporal lobe epilepsy (TLE) and extratemporal epilepsy (using frontal lobe epilepsy (FLE) a surrogate) further, we performed a retrospective analysis of a large cohort of patients with seizure-onset zone proven by intracranial monitoring. METHODS: A total of 120 TLE patients, 86 FLE patients, and 54 healthy controls were enrolled in this study. An analysis of variance of voxel-based morphometry (VBM) was used to seek morphometric brain differences among TLE patients, FLE patients, and healthy controls. Additionally, a vertex-based surface analysis was utilized to analyze the hippocampus and thalamus. Significant side-specific differences in hippocampal gray matter volume were present between the left TLE (LTLE), right TLE RTLE (RTLE), and control groups (p<0.05, family-wise error (FWE) corrected). RESULTS: Vertex analyses revealed significant volume reduction in inferior parts of the left hippocampus in the LTLE group and lateral parts of the right hippocampus in the RTLE group compared to controls (p<0.05, FWE corrected). Significant differences were also detected between the LTLE and control group in the bilateral medial and inferior thalamus (p<0.05, FWE corrected). FLE patients did not exhibit focal atrophy of gray matter across the brain. CONCLUSION: Our results highlight the variation in morphometric lateralized changes in the brain between different epilepsy onset zones, providing critical insight into the natural history of people with drug-resistant focal epilepsies.
PURPOSE: Exploration of the effect of chronic recurrent seizures in focal epilepsy on brain volumes has produced many conflicting reports. To determine differences in brain structure in temporal lobe epilepsy (TLE) and extratemporal epilepsy (using frontal lobe epilepsy (FLE) a surrogate) further, we performed a retrospective analysis of a large cohort of patients with seizure-onset zone proven by intracranial monitoring. METHODS: A total of 120 TLE patients, 86 FLE patients, and 54 healthy controls were enrolled in this study. An analysis of variance of voxel-based morphometry (VBM) was used to seek morphometric brain differences among TLE patients, FLE patients, and healthy controls. Additionally, a vertex-based surface analysis was utilized to analyze the hippocampus and thalamus. Significant side-specific differences in hippocampal gray matter volume were present between the left TLE (LTLE), right TLE RTLE (RTLE), and control groups (p<0.05, family-wise error (FWE) corrected). RESULTS: Vertex analyses revealed significant volume reduction in inferior parts of the left hippocampus in the LTLE group and lateral parts of the right hippocampus in the RTLE group compared to controls (p<0.05, FWE corrected). Significant differences were also detected between the LTLE and control group in the bilateral medial and inferior thalamus (p<0.05, FWE corrected). FLE patients did not exhibit focal atrophy of gray matter across the brain. CONCLUSION: Our results highlight the variation in morphometric lateralized changes in the brain between different epilepsy onset zones, providing critical insight into the natural history of people with drug-resistant focal epilepsies.
Authors: N Tzourio-Mazoyer; B Landeau; D Papathanassiou; F Crivello; O Etard; N Delcroix; B Mazoyer; M Joliot Journal: Neuroimage Date: 2002-01 Impact factor: 6.556
Authors: Marina K M Alvim; Ana C Coan; Brunno M Campos; Clarissa L Yasuda; Mariana C Oliveira; Marcia E Morita; Fernando Cendes Journal: Epilepsia Date: 2016-02-11 Impact factor: 5.864
Authors: Christopher D Whelan; Andre Altmann; Juan A Botía; Neda Jahanshad; Derrek P Hibar; Julie Absil; Saud Alhusaini; Marina K M Alvim; Pia Auvinen; Emanuele Bartolini; Felipe P G Bergo; Tauana Bernardes; Karen Blackmon; Barbara Braga; Maria Eugenia Caligiuri; Anna Calvo; Sarah J Carr; Jian Chen; Shuai Chen; Andrea Cherubini; Philippe David; Martin Domin; Sonya Foley; Wendy França; Gerrit Haaker; Dmitry Isaev; Simon S Keller; Raviteja Kotikalapudi; Magdalena A Kowalczyk; Ruben Kuzniecky; Soenke Langner; Matteo Lenge; Kelly M Leyden; Min Liu; Richard Q Loi; Pascal Martin; Mario Mascalchi; Marcia E Morita; Jose C Pariente; Raul Rodríguez-Cruces; Christian Rummel; Taavi Saavalainen; Mira K Semmelroch; Mariasavina Severino; Rhys H Thomas; Manuela Tondelli; Domenico Tortora; Anna Elisabetta Vaudano; Lucy Vivash; Felix von Podewils; Jan Wagner; Bernd Weber; Yi Yao; Clarissa L Yasuda; Guohao Zhang; Nuria Bargalló; Benjamin Bender; Neda Bernasconi; Andrea Bernasconi; Boris C Bernhardt; Ingmar Blümcke; Chad Carlson; Gianpiero L Cavalleri; Fernando Cendes; Luis Concha; Norman Delanty; Chantal Depondt; Orrin Devinsky; Colin P Doherty; Niels K Focke; Antonio Gambardella; Renzo Guerrini; Khalid Hamandi; Graeme D Jackson; Reetta Kälviäinen; Peter Kochunov; Patrick Kwan; Angelo Labate; Carrie R McDonald; Stefano Meletti; Terence J O'Brien; Sebastien Ourselin; Mark P Richardson; Pasquale Striano; Thomas Thesen; Roland Wiest; Junsong Zhang; Annamaria Vezzani; Mina Ryten; Paul M Thompson; Sanjay M Sisodiya Journal: Brain Date: 2018-02-01 Impact factor: 13.501
Authors: Adriana Di Martino; David O'Connor; Bosi Chen; Kaat Alaerts; Jeffrey S Anderson; Michal Assaf; Joshua H Balsters; Leslie Baxter; Anita Beggiato; Sylvie Bernaerts; Laura M E Blanken; Susan Y Bookheimer; B Blair Braden; Lisa Byrge; F Xavier Castellanos; Mirella Dapretto; Richard Delorme; Damien A Fair; Inna Fishman; Jacqueline Fitzgerald; Louise Gallagher; R Joanne Jao Keehn; Daniel P Kennedy; Janet E Lainhart; Beatriz Luna; Stewart H Mostofsky; Ralph-Axel Müller; Mary Beth Nebel; Joel T Nigg; Kirsten O'Hearn; Marjorie Solomon; Roberto Toro; Chandan J Vaidya; Nicole Wenderoth; Tonya White; R Cameron Craddock; Catherine Lord; Bennett Leventhal; Michael P Milham Journal: Sci Data Date: 2017-03-14 Impact factor: 6.444
Authors: A Di Martino; C-G Yan; Q Li; E Denio; F X Castellanos; K Alaerts; J S Anderson; M Assaf; S Y Bookheimer; M Dapretto; B Deen; S Delmonte; I Dinstein; B Ertl-Wagner; D A Fair; L Gallagher; D P Kennedy; C L Keown; C Keysers; J E Lainhart; C Lord; B Luna; V Menon; N J Minshew; C S Monk; S Mueller; R-A Müller; M B Nebel; J T Nigg; K O'Hearn; K A Pelphrey; S J Peltier; J D Rudie; S Sunaert; M Thioux; J M Tyszka; L Q Uddin; J S Verhoeven; N Wenderoth; J L Wiggins; S H Mostofsky; M P Milham Journal: Mol Psychiatry Date: 2013-06-18 Impact factor: 15.992