Literature DB >> 34310646

Modeling the survival times of the COVID-19 patients with a new statistical model: A case study from China.

Xiaofeng Liu1, Zubair Ahmad2, Ahmed M Gemeay3, Alanazi Talal Abdulrahman4, E H Hafez5, N Khalil6.   

Abstract

Over the past few months, the spread of the current COVID-19 epidemic has caused tremendous damage worldwide, and unstable many countries economically. Detailed scientific analysis of this event is currently underway to come. However, it is very important to have the right facts and figures to take all possible actions that are needed to avoid COVID-19. In the practice and application of big data sciences, it is always of interest to provide the best description of the data under consideration. The recent studies have shown the potential of statistical distributions in modeling data in applied sciences, especially in medical science. In this article, we continue to carry this area of research, and introduce a new statistical model called the arcsine modified Weibull distribution. The proposed model is introduced using the modified Weibull distribution with the arcsine-X approach which is based on the trigonometric strategy. The maximum likelihood estimators of the parameters of the new model are obtained and the performance these estimators are assessed by conducting a Monte Carlo simulation study. Finally, the effectiveness and utility of the arcsine modified Weibull distribution are demonstrated by modeling COVID-19 patients data. The data set represents the survival times of fifty-three patients taken from a hospital in China. The practical application shows that the proposed model out-classed the competitive models and can be chosen as a good candidate distribution for modeling COVID-19, and other related data sets.

Entities:  

Mesh:

Year:  2021        PMID: 34310646      PMCID: PMC8312982          DOI: 10.1371/journal.pone.0254999

Source DB:  PubMed          Journal:  PLoS One        ISSN: 1932-6203            Impact factor:   3.240


1 Introduction

The first outbreak of the current COVID-19 epidemic was first seen in the popular seafood market in the Chinese city of Wuhan, where large numbers of people come to buy or sell seafood. As of December 31, 2019, a total of 27 cases of COVD-19 epidemic were reported by the WMHC (Wuhan Municipal Health Commission). After highly effecting some Chines cities and provinces, this pandemic transmitted to other countries via air routes [1]. Almost every country around the globe has paid a huge price in terms of financial and human loss, and yet, some countries are paying and in sacrifice process. The countries having large population densities and low health facilities have higher chances of being in critical situations during this pandemic [2]. The main serious and common symptoms attributed to COVID-19 are sore throat (13.9%), dry cough (67.7%), Fever (87.9%), shortness of breath (18.6%), headache (13.6%), fatigue (38.1%), sputum production (33.4%), muscle pain (14.8%), nausea (5.0%), nasal congestion (4.8%), haemoptysis (0.9%) and conjunctival congestion (0.8%). For more detail about the symptoms of COVID-19 pandemic; see [3]. The % of symptoms are displayed in Fig 1.
Fig 1

Graphical display for the percentage of the symptoms of COVID-19.

The comparison of COVID-19 epidemic between different countries is worth of studies and is of great concern. In this regard, researchers are devoting great efforts to make comparisons between different countries. For some previous attempts to compare this epidemic in Italy and China; see [4] for details. Comparison of COVID-19 in Europe, USA, and South Korea is provided in [5]. The COVID-19 pandemic in Australia has been discussed in [6]. Modeling the spread of COVID-19 in Lebanon is provided in [7]. A case study form Spain has been studied in [8]. Mathematical analysis of COVID-19 in Mexico is provided in [9]. A case study form Brazil is discussed in [10]. The progress of COVID-19 epidemic in Pakistan is studied by [11]. A mathematical model for COVID-19 transmission dynamics in India is provided by [12]. Al-Babtain et al. [13] introduced two case studies in Saudi Arabia, the first one about COVID-19 infections from 24 March to 12 April, 2020 and the second about numbers of daily recover patients in the same period of time. Comparison of COVID-19 events in Asian countries has been carried out in [14]. The comparison between Iran and mainland China has appeared in [15]. The comparison between the two neighbour countries Iran and Pakistan has appeared in [16]. A case of the COVID-19 pandemic in Indonesia has been discussed in [17]. For more information, reader can refer to [18-27]. In the current situation, it is of great interest to study more about COVID-19 to make comparison between different countries. In the domain and practice of big data science, to provide the best description of the data under consideration is a prominent research topic. The recent studies have pointed out the applicability of statistical models to provide the best description of the random phenomena. In this article, we focus on this research area of distribution theory, and introduce a new statistical model to provide the best fit to data in linked with COVID-19 and other related events. The modified Weibull distribution is one of the most prominent modifications of the Weibull distribution which is introduced to improve the fitting power of the exponential, Rayleigh, linear failure rate and Weibull distributions; see [28]. We further carry this area of distribution theory and introduce a new prominent version of the modified Weibull distribution to improve its fitting power. A random variable X, is said to follow the modified Weibull distribution with shape parameter α and scale parameters κ1 and κ2, if its cdf (cumulative distribution function) denoted F(x;Ξ), is given by where Ξ = (α, κ1, κ2). The pdf (probability density function) corresponding to expression Eq 1 is In this article, we focus on proposing a new modification of the modified Weibull distribution called the arcsine modified Weibull (ASM-Weibull) distribution. The ASM-Weibull distribution is introduced by adopting the approach of the arcsine-X distributions of [29], which can be obtained as a sub-case of [30]. The cdf and pdf of the arcsine-X distributions are given, respectively, by where F(x;Ξ) is cdf of the baseline random variable. The respective pdf is The cdf of the proposed ASM-Weibull distribution is obtained by using the expression 1 in 2. The flexibility and applicability of the ASM-Weibull distribution are examined via an application to the survival times of the COVID-19 patient data.

2 The arcsine-modified weibull model

In this section, we introduce the ASM-Weibull distribution. A random variable X, is said to follow the ASM-Weibull distribution, if its cdf is given by The density function corresponding to 3 is given by Some possible behaviors of the pdf of the ASM-Weibull distribution are shown in Fig 2. The plots in the right panel of Fig 2, are sketched for α = 6.5, κ1 = 1.5, κ2 = 0.5 (red-line), α = 5.4, κ1 = 0.5, κ2 = 0.9 (green-line), α = 4.6, κ1 = 1.5, κ2 = 1.5 (black-line), α = 3.8, κ1 = 1.5, κ2 = 2.5 (blue-line). Whereas, the plots in the left panel of Fig 2, are presented for α = 0.5, κ1 = 1.5, κ2 = 1.5 (red-line), α = 2.5, κ1 = 2.5, κ2 = 0.1 (green-line), α = 1.6, κ1 = 1.2, κ2 = 0.5 (black-line), α = 2.8, κ1 = 1.8, κ2 = 1.2 (blue-line).
Fig 2

Different density plots of the ASM-Weibull distribution.

Some possible behaviors of the hazard rate function (hrf) h(x) of the ASM-Weibull distribution are shown in Fig 3. The plots provided in Fig 3, are sketched for α = 0.5, κ1 = 0.5, κ2 = 1 (red-line), α = 1.5, κ1 = 0.8, κ2 = 0.5 (green-line), α = 1.5, κ1 = 2.1, κ2 = 1.5 (blue-line),α = 1.2, κ1 = 0.9, κ2 = 1.2 (gold-line), α = 2.4, κ1 = 0.5, κ2 = 1.8 (black-line). From the plots provided in Fig 3, we can see that the proposed model captures different important behaviours of the hrf such as increasing, decreasing, unimodal also called upside down bathtub, modified unimodal and most importantly bathtub shapes.
Fig 3

Different hrf plots of the ASM-Weibull distribution.

3 Basic mathematical properties

This section deals with the computation of some statistical properties of the ASM-Weibull distribution.

3.1 Quantile function

Let X denote the ASM-Weibull random variable with cdf 3, then the qf (quantile function) of X, denoted Q(u), is given by where u has the uniform distribution on the interval (0,1).

3.2 Moments

This subsection deals with the computation of r moment of the ASM-Weibull distribution that can be further used to obtain important characteristics. It is often employed in computing the main properties and characteristics of the distribution (as an example of this characteristics skewness, central tendency, dispersion, and kurtosis). In this section, we derive the r moment of the ASM-Weibull distribution as follows Using binomial series that is convergent when |t| < 1 (see, https://socratic.org/questions/how-do-you-use-the-binomial-series-to-expand-f-x-1-sqrt-1-x-2), we have Using 7, we have The expression 8 can also be written as Using expression 9 in 6, we have Using the series e−, we have Let t = κ1(i + 1)x, then using the expression 11, we get Using expression 12 in 10, we get For different values of α and κ2, and fixed value of κ1, the plots of mean, variance, skewness, and kurtosis of the ASM-Weibull distribution are presented in Figs 4 and 5.
Fig 4

Plots of the mean, variance, skewness and kurtosis for κ1 = 1.2 and different values of α and κ2.

Fig 5

Plots of the mean, variance, skewness and kurtosis for κ1 = 0.5 and different values of α and κ2.

Furthermore, the mgf (moment generating function) of the ASM-Weibull distribution denoted by M(t) has the form

4 Maximum likelihood estimation

Here, we derive the maximum likelihood estimators (MLEs) of the ASM-Weibull distribution parameters based on the complete samples only. Let x1, x2, …, x represent the observed values from the ASM-Weibull distribution with parameters α, κ1 and κ2. Corresponding to Eq 4, the total log-likelihood function ℓ(α, κ1, κ2) is given by The numerical maximization of ℓ(α, κ1, κ2) can be done either by using the computer software or via differentiation on behalf of α, κ1 and κ2. Corresponding to Eq 13, the partial derivatives are as follows Solving , yield the MLEs of (α, κ1, κ2). For more information and extensive reading about MLEs, we refer to [31-34].

5 Simulation study

In this section of the paper, we provide a brief Monte Carlo simulation study to evaluate the MLEs of the ASM-Weibull distribution parameters. The ASM-Weibull distribution is easily simulated by inverting the expression 3. Let U has a uniform distribution U(0,1), then the nonlinear equation by inverting Eq 3 is The simulation is performed for two different sets of parameters (i) α = 0.7, κ1 = 1, κ2 = 0.5, and (ii) α = 1.2, κ1 = 1.4, κ2 = 0.5. The random number generation is obtained via the inverse cdf. The inverse process and simulation results are obtained via a statistical software R using (rootSolve) library with command mle. The sample size selected as n = 10, 20, …, 500 and the Monte Carlo replications made was 500 times. For the maximization of the expression 13, the algorithm “LBFGS-B” is used with optim(). For i = 1, 2, …, 500, the MLEs of (α, κ1, κ2) are obtained for each set of simulated data. The assessing tools such as biases and mean square errors (MSEs) are considered. These quantities are calculated as follows and where Θ = (α, κ1, κ2). The coverage probabilities (CPs) are calculated at the 95% confidence interval (C.I). The summary measures of the simulated data presented in Table 1 and the box plots are provided in Fig 6.
Table 1

The summary measures of the simulated data sets.

Simulated DataMin.1st Qu.MedianMean3rd Qu.Max.
Set 10.0011.0132.7104.7366.23259.042
Set 20.00000.07380.45501.96081.594746.0600
Fig 6

Box plots of the simulated data set 1 (red color) and set 2 (blue color).

For the simulated data set 1, (i) the histogram and Kernel density estimator are presented in Fig 7, (ii) the fitted pdf and cdf are sketched in Fig 8, and (iii) the Kaplan-Meier survival and QQ (quantile-quantile) plots are provided in Fig 9. Corresponding to the first set of parameters values, the simulations results are provided in Table 2.
Fig 7

The histogram and Kernel density estimator of the simulated data set 1.

Fig 8

The fitted pdf and cdf of the ASM-Weibull model for the simulated data set 1.

Fig 9

The QQ and Kaplan-Meier survival plots of the ASM-Weibull model for the simulated data set 1.

Table 2

The Monte Carlo simulation results of the ASM-Weibull distribution.

Set 1: α = 0.7, κ1 = 1, κ2 = 0.5
nPar.MLEMSEsBiasesConfidence IntervalCPsVariances
10α0.951630.309830.24163(0.30356, 1.47970)0.9820.90602
κ11.416242.974150.41624(-4.62888, 3.46137)0.9901.56130
κ20.810040.418800.21004(-1.73901, 3.15911)0.8842.92010
20α0.906930.274310.20693(0.40446, 1.20940)0.9780.84216
κ11.393782.186880.35937(-2.39180, 3.19793)0.9761.20960
κ20.796250.379740.19625(-1.41940, 2.89190)0.8902.71498
100α0.861740.212620.14174(0.54005, 0.94342)0.9060.61058
κ11.368271.410300.29827(-1.11438, 3.06107)0.9560.98438
κ20.734790.291310.15479(-0.41042, 1.68002)0.9121.45309
200α0.833390.158290.10339(0.56393, 0.90399)0.9260.47525
κ11.322760.606290.16276(-0.41898, 2.54452)0.9500.17330
κ20.630170.143270.13017(-0.18576, 1.44611)0.9080.57153
300α0.796760.106420.09676(0.58486, 0.86866)0.9030.15241
κ11.219620.394050.10962(-0.15800, 2.19726)0.9240.11109
κ20.609060.118510.10906(-0.04422, 1.26235)0.9580.36099
400α0.766100.076000.05610(0.59241, 0.83979)0.9240.03982
κ11.152220.290890.09222(0.04500, 2.17945)0.9340.07579
κ20.570350.091270.07035(0.03073, 1.10997)0.9480.29648
500α0.712240.005470.02224(0.60464, 0.83984)0.9400.00359
κ11.082120.129970.03212(0.01549, 1.99875)0.9370.07283
κ20.524660.066170.02664(0.06971, 1.12761)0.9290.24828
For the simulated data set 2, (i) the histogram and Kernel density estimator are presented in Fig 10, (ii) the fitted pdf and cdf are sketched in Fig 11, and (iii) the Kaplan-Meier survival and QQ (quantile-quantile) plots are provided in Fig 12. Whereas, the corresponding simulation results are given in Table 3.
Fig 10

The histogram and Kernel density estimator of the simulated data set 2.

Fig 11

The fitted pdf and cdf of the ASM-Weibull model for the simulated data set 2.

Fig 12

The QQ and Kaplan-Meier survival plots of the ASM-Weibull model for the simulated data set 2.

Table 3

The Monte Carlo simulation results of the ASM-Weibull distribution.

Set 1: α = 0.5, κ1 = 1.2, κ2 = 1
nPar.MLEMSEsBiasesConfidence IntervalCPsVariances
10α0.665820.536510.48321(0.21252, 0.95390)0.9800.13576
κ11.405711.361610.50571(0.74426, 2.15565)0.9321.37804
κ21.385160.566820.38516(0.47090, 2.24122)0.9861.13841
20α0.632650.476840.43265(0.28860, 0.77669)0.9580.10550
κ11.386571.258440.46576(0.69955, 1.83109)0.9121.26905
κ21.315830.969980.35837(0.20597, 1.98737)0.9581.06494
100α0.614960.433140.38556(0.36773, 0.72455)0.9260.09422
κ11.329311.218510.40310(0.40705, 2.39326)0.9101.17722
κ21.270440.948300.27044(0.13789, 2.89926)0.9781.10603
200α0.583260.370530.31410(0.39251, 0.69401)0.9120.05642
κ11.308191.091000.35819(-0.80415, 2.00575)0.9241.09821
κ21.210570.765380.21057(-1.2665r, 2.17690)0.8721.01865
300α0.567730.278310.12262(0.40840, 0.65870)0.9180.02077
κ11.276890.979880.16786(-0.70062, 1.96376)0.9080.92467
κ21.167860.713120.20786(-0.78556, 2.10588)0.9000.83218
400α0.535870.104370.04126(0.40902, 0.58272)0.9040.00996
κ11.239660.686060.10673(-0.53937, 1.67285)0.9200.59047
κ21.101520.795170.14525(-0.53139, 1.96108)0.8960.68642
500α0.512900.001710.00706(0.42042, 0.56538)0.9660.00136
κ11.211240.393900.04124(-0.31099, 1.43478)0.9780.47598
κ21.082390.477540.09392(-0.27358, 1.86431)0.9760.56431

6 Applications to COVID-19 data sets

The main interest of the derivation of the ASM-Weibull distribution is its use in data analysis objectives, which makes it useful in many fields, particularly, in the fields dealing with lifetime analysis. Here, this feature is illustrated via taking two sets of data related to COVID-19 epidemic events. We illustrate the best fitting power of the ASM-Weibull as compared with the other two parameters, three parameters and four parameters well-known lifetime competitive distributions namely: inverse Weibull (IW), extend odd Weibull exponential (ETOWE), Kumaraswamy Weibull (Ku-W), odd log-logistic modified Weibull (OLL-MW), and Frechet Weibull (FW) distributions. The pdfs of the competitive models are Ku-W distribution OLL-MW FW IW ETOWE We show that the ASM-Weibull distribution provides the best fit to the lifetime data related to the COVID-19 epidemic. The term “best fit” is used in the sense that the proposed model has smaller values of the criterion selected for comparison. These criterion consist of some discrimination measures. These measures are The AIC (Akaike information criterion) The CAIC (Corrected Akaike information criterion) The BIC (Bayesian information criterion) The HQIC (Hannan-Quinn information criterion) where ℓ is the value of the log-likelihood function under the MLE, k refers to the number of parameters of the model, and n is the sample size. In addition to these measures, we also consider other important goodness of fit measures including the Anderson-Darling (AD) statistic, Cramer-von Mises (CM) statistic and the Kolmogorov-Smirnov (KS) statistic with p-value, for detail information about these measures see [35]. A model with the lowest values of the above mentioned measures could be chosen as the best model for the real data set. For the computation of the numerical results, we use the Newton-Raphson iteration procedure with optim() R-function with the argument method =“BFGS” to estimate the model parameters. The numerical estimates of the unknown parameters of the ASM-Weibull and other fitted distributions are obtained using the R-script AdequacyModel with the “BFGS” algorithm.

6.1 Survival times of the COVID-19 patients data

In this subsection, we consider the survival times of patients suffering from the COVID-19 epidemic in China. The considered data set representing the survival times of patients from the time admitted to the hospital until death. Among them, a group of fifty-three (53) COVID-19 patients were found in critical condition in hospital from January to February 2020. Among them, 37 patients (70%) were men and 16 women (30%). 40 patients (75%) were diagnosed with chronic diseases, especially including high blood pressure, and diabetes. 47 patients (88%) had common clinical symptoms of the flu, 42 patients (81%) were coughing, 37 (69%) were short of breath, and 28 patients (53%) had fatigue. 50 (95%) patients had bilateral pneumonia showed by the chest computed tomographic scans. The data set can be retrieved from https://www.worldometers.info/coronavirus/ and is given by: 0.054, 0.064, 0.704, 0.816, 0.235, 0.976, 0.865, 0.364, 0.479, 0.568, 0.352, 0.978, 0.787, 0.976, 0.087, 0.548, 0.796, 0.458, 0.087, 0.437, 0.421, 1.978, 1.756, 2.089, 2.643, 2.869, 3.867, 3.890, 3.543, 3.079, 3.646, 3.348, 4.093, 4.092, 4.190, 4.237, 5.028, 5.083, 6.174, 6.743, 7.274, 7.058, 8.273, 9.324, 10.827, 11.282, 13.324, 14.278, 15.287, 16.978, 17.209, 19.092, 20.083. The summary measures of the first data are provided in Table 4. Whereas, The histogram of COVID-19 data along with the total time test (TTT) plot are sketched in Fig 13, shows that the data set is right-skewed (histogram).
Table 4

The summary measures of the first COVID-19 data.

Min.1st Qu.MedianMean3rd Qu.Max.
0.0540.7043.0794.7876.74320.083
Fig 13

Histogram and TTT plot of the COVID-19 data 1.

The MLEs of the ASM-Weibull and other models are provided in Table 5. The discrimination measures of the fitted distributions are provided in Table 6, and the goodness of fit measures are provided in Table 7.
Table 5

Corresponding to the first COVID-19 data, the estimated values of the parameters of the fitted distributions.

Model α^ κ1^ κ2^ σ^ a^ b^ λ^
ASM-Weibull0.82900.53320.0156
MOW0.70460.44041.4888
Ku-W0.79683.25001.09670.0959
T-MW0.78640.27090.02270.1145
B-MW0.44322.93850.02882.88550.2178
OLL-MW0.78460.76930.09701.9086
FW0.51960.50451.18041.9838
Table 6

Corresponding to the first COVID-19 data, the discrimination measures of the fitted models.

ModelAICCAICBICHQIC
ASM-Weibull272.3406272.8304278.2515274.6136
MOW273.3886273.8784279.2994275.6616
Ku-W274.1946275.0279282.0757277.2253
T-MW274.7410275.5743282.6222277.7717
B-MW274.0107275.2873283.8622277.7991
OLL-MW275.1094275.9765284.4875278.0921
FW292.8950293.7280300.7760295.9260
Table 7

Corresponding to the first COVID-19 data, the goodness of fit measures of the fitted models.

ModelCMADKSp-value
ASM-Weibull0.07230.45550.12260.4022
MOW0.07720.49570.12900.3405
Ku-W0.07400.46400.13860.2600
T-MW0.07560.47500.12400.3885
B-MW0.07970.49760.14350.3024
OLL-MW0.08140.52090.15060.2815
FW0.24731.69300.14350.2250
From the values of the criteria provided in Tables 6 and 7, we see that the ASM-Weibull model is far from the concurrence. Indeed, for the COVID-19 lifetime data, for instance, it satisfies smaller values of the AIC, CAIC, BIC, HQIC, CM, AD, KS and high p-value against the AIC, CAIC, BIC, HQIC, CM, AD, KS and high p-value for the second-best distribution. Furthermore, for the COVID-19 lifetime data, a graphical check of the fit of the ASM-Weibull model are presented in Fig 14. For this purpose, we consider the curves of the estimated pdf, cdf, PP (probability-probability) and Kaplan-Meier survival plots of the ASM-Weibull distribution. For the ASM-Weibull model, the estimated cdf and pdf are given by and , respectively, where G(x;α, κ1, κ2) is defined by Eq 3, g(x;α, κ1, κ2) is defined by Eq 4, and are the obtained MLEs for (α, κ1, κ2). For instance, based on Eq 3, the second row of Table 5, and the plot of the ASM-Weibull distribution in Fig 14 representing the estimated cdf is given by with estimated pdf
Fig 14

The estimated pdf, cdf, PP and Kaplan-Meier survival plots of the ASM-Weibull distribution for the COVID-19 data.

From the plots sketched in Fig 14, we see that the ASM-Weibull curves are closer to the corresponding empirical objects. The above practical results show that the ASM-Weibull distribution is an efficient model to adjust the considered survival times of the COVID-19’s patients in China. Furthermore, graphical display of the existence and uniqueness of the MLEs are shown in Figs 15 and 16, respectively. Fig 15 confirms the existence of MLEs as the log-likelihood function intersects the x-axis at one point. Furthermore, Fig 16 shows that the MLEs are unique as the log-likelihood function has global maximum roots.
Fig 15

This figure indicates the existences of the log likelihood function as each curve intersect the x-axis at one point.

Fig 16

This figure indicates that the log likelihood roots are global maximum.

6.2 Second real data set

The second data set represents the mortality rate of the COVID-19 patients in Canada. This data set is available at https://covid19.who.int/, and given by: 3.1091, 3.3825, 3.1444, 3.2135, 2.4946, 3.5146, 4.9274, 3.3769, 6.8686, 3.0914, 4.9378, 3.1091, 3.2823, 3.8594, 4.0480, 4.1685, 3.6426, 3.2110, 2.8636, 3.2218, 2.9078, 3.6346, 2.7957, 4.2781, 4.2202, 1.5157, 2.6029, 3.3592, 2.8349, 3.1348, 2.5261, 1.5806, 2.7704, 2.1901, 2.4141, 1.9048. Corresponding to this data set, the summary measures are provided in Table 8. Whereas, the histogram and TTT plots are sketched in Fig 17.
Table 8

The summary measures of the second COVID-19 data set.

Min.1st Qu.MedianMean3rd Qu.Max.
1.5162.7893.1783.2823.6376.869
Fig 17

Histogram and TTT plot of the second COVID-19 data set.

For the second data set, the MLEs of the ASM-Weibull and other models are provided in Table 9. The discrimination and goodness of fit measures are provided in Tables 10 and 11, respectively.
Table 9

Corresponding to the second COVID-19 data, the estimated values of the parameters of the fitted distributions.

Model α^ κ1^ κ2^ a^ b^ λ^
ASM-Weibull3.476680.0200290.000918
Ku-W2.637820.4483721.524140.525173
OLL-MW4.567166.99444× 10−290.0010070.606009
FW1.403461.73832.258082.11702
IW2.704363.16912
ETOWE1.073775.84409 × 1081.65812 × 108
Table 10

Corresponding to the second COVID-19 data, the discrimination measures of the fitted models.

ModelAICCAICBICHQIC
ASM-Weibull109.437110.187114.188111.095
Ku-W119.739121.03126.074121.95
OLL-MW151.286152.576157.62153.497
FW113.84115.13120.174116.051
IW109.84110.204113.007110.946
ETOWE163.56164.31168.31165.218
Table 11

Corresponding to the second COVID-19 data, the goodness of fit measures of the fitted models.

ModelCMADKSp-value
ASM-Weibull1.212310.2125350.1546950.355032
Ku-W3.525840.7039550.2656310.0124359
OLL-MW8.816081.967550.3975710.000022
FW1.618030.2744790.1737570.227156
IW1.618030.2744790.1737570.227156
ETOWE8.946241.867790.409610.000011
From the values of the selected criteria reported in Tables 10 and 11, we see that the ASM-Weibull model is a better model as it has the smaller values of the AIC, CAIC, BIC, HQIC, CM, AD, KS and high p-value against the AIC, CAIC, BIC, HQIC, CM, AD, KS and high p-value for the second-best distribution. Furthermore, for the second COVID-19 data, the graphical display of the pdf, cdf, PP (probability-probability) and Kaplan-Meier survival plots of the ASM-Weibull distribution are presented in Fig 18. The graphs sketched in Fig 18, show that the ASM-Weibull distribution provide the best description to the COVID-19 mortality rate data. For the second data set, the likelihood function is plotted in Figs 19 and 20, which confirms the existence and uniqueness properties of the MLEs, respectively.
Fig 18

The estimated pdf, cdf, PP and Kaplan-Meier survival plots of the ASM-Weibull distribution for the second COVID-19 data.

Fig 19

This figure indicates the existences of the log likelihood function as each curve intersect the x-axis at one point for the second data set.

Fig 20

This figure indicates that the log likelihood roots are global maximum for the second data set.

7 Concluding remarks

The two-parameter Weibull model has shown great applicability in the practice of statistical sciences particularly, reliability engineering, biomedical and financial sciences. In this study, a new modification of the Weibull model is introduced using the modified Weibull distribution with the “Arcsine strategy”. The proposed model is called the arcsine modified Weibull distribution. The maximum likelihood estimators of the ASM-Weibull parameters are obtained and a Monte Carlo simulation study is conducted. To show the applicability of the ASM-Weibull model, two real-life data sets related to COVID-19 events are considered. The comparison of the proposed model is made with the other well-known competitors. To figure out the close fitting of the fitted distributions, certain analytical tools including four discrimination measures and three goodness of fit measures as well as the p-value are considered. Based on these analytical measures, we showed that the ASM-Weibull model provides a better fit than the other competitors, supported by graphical sketching and numerical tools. Furthermore, corresponding to COVID-19 data sets, the log-likelihood function is also plotted confirming the existence and uniqueness properties of the MLEs. We hope that beyond the scope of this paper, the ASM-Weibull can be applied to analyze other forms of the COVID-19 data.
  20 in total

Review 1.  The reproductive number of COVID-19 is higher compared to SARS coronavirus.

Authors:  Ying Liu; Albert A Gayle; Annelies Wilder-Smith; Joacim Rocklöv
Journal:  J Travel Med       Date:  2020-03-13       Impact factor: 8.490

2.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.

Authors:  Chaolin Huang; Yeming Wang; Xingwang Li; Lili Ren; Jianping Zhao; Yi Hu; Li Zhang; Guohui Fan; Jiuyang Xu; Xiaoying Gu; Zhenshun Cheng; Ting Yu; Jiaan Xia; Yuan Wei; Wenjuan Wu; Xuelei Xie; Wen Yin; Hui Li; Min Liu; Yan Xiao; Hong Gao; Li Guo; Jungang Xie; Guangfa Wang; Rongmeng Jiang; Zhancheng Gao; Qi Jin; Jianwei Wang; Bin Cao
Journal:  Lancet       Date:  2020-01-24       Impact factor: 79.321

3.  SutteARIMA: Short-term forecasting method, a case: Covid-19 and stock market in Spain.

Authors:  Ansari Saleh Ahmar; Eva Boj Del Val
Journal:  Sci Total Environ       Date:  2020-04-22       Impact factor: 7.963

4.  On a new conceptual mathematical model dealing the current novel coronavirus-19 infectious disease.

Authors:  Anwarud Din; Kamal Shah; Aly Seadawy; Hussam Alrabaiah; Dumitru Baleanu
Journal:  Results Phys       Date:  2020-11-06       Impact factor: 4.476

5.  Investigating the cases of novel coronavirus disease (COVID-19) in China using dynamic statistical techniques.

Authors:  Samuel Asumadu Sarkodie; Phebe Asantewaa Owusu
Journal:  Heliyon       Date:  2020-04-04

6.  Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China.

Authors:  Benjamin F Maier; Dirk Brockmann
Journal:  Science       Date:  2020-04-08       Impact factor: 47.728

7.  Real-time forecasts of the COVID-19 epidemic in China from February 5th to February 24th, 2020.

Authors:  K Roosa; Y Lee; R Luo; A Kirpich; R Rothenberg; J M Hyman; P Yan; G Chowell
Journal:  Infect Dis Model       Date:  2020-02-14

8.  The behaviour of infection, survival and testing effort variables of SARS-CoV-2: A theoretical modelling based on optimization technique.

Authors:  Subhasis Bhattacharya; Suman Paul
Journal:  Results Phys       Date:  2020-11-11       Impact factor: 4.476

9.  An SEIARD epidemic model for COVID-19 in Mexico: Mathematical analysis and state-level forecast.

Authors:  Ugo Avila-Ponce de León; Ángel G C Pérez; Eric Avila-Vales
Journal:  Chaos Solitons Fractals       Date:  2020-08-19       Impact factor: 5.944

10.  Facemasks simple but powerful weapons to protect against COVID-19 spread: Can they have sides effects?

Authors:  Ernestine Atangana; Abdon Atangana
Journal:  Results Phys       Date:  2020-09-30       Impact factor: 4.476

View more
  4 in total

1.  Mathematical modeling of the impact of Omicron variant on the COVID-19 situation in South Korea.

Authors:  Jooha Oh; Catherine Apio; Taesung Park
Journal:  Genomics Inform       Date:  2022-06-22

2.  The new discrete distribution with application to COVID-19 Data.

Authors:  Ehab M Almetwally; Doaa A Abdo; E H Hafez; Taghreed M Jawa; Neveen Sayed-Ahmed; Hisham M Almongy
Journal:  Results Phys       Date:  2021-12-05       Impact factor: 4.476

3.  A new versatile modification of the Rayleigh distribution for modeling COVID-19 mortality rates.

Authors:  Mutua Kilai; Gichuhi A Waititu; Wanjoya A Kibira; M M Abd El-Raouf; Tahani A Abushal
Journal:  Results Phys       Date:  2022-02-22       Impact factor: 4.476

4.  Short-Term Prediction of COVID-19 Using Novel Hybrid Ensemble Empirical Mode Decomposition and Error Trend Seasonal Model.

Authors:  Dost Muhammad Khan; Muhammad Ali; Nadeem Iqbal; Umair Khalil; Hassan M Aljohani; Amirah Saeed Alharthi; Ahmed Z Afify
Journal:  Front Public Health       Date:  2022-07-29
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.