Monica Maria Pagliara1, Luca Tagliaferri2, Gustavo Savino3, Bruno Fionda2, Andrea D'Aviero2, Angela Lanza4, Valentina Lancellotta2, Giulia Midena3, Maria Antonietta Gambacorta5, Maria Antonietta Blasi3. 1. UOC Oncologia Oculare, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 2. UOC Radioterapia Oncologica, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 3. UOC Oncologia Oculare, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy. 4. Ocular Unit, Ospedale Teresa Masselli, Foggia, Italy. 5. UOC Radioterapia Oncologica, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS - Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Abstract
PURPOSE: To evaluate local control and functional and cosmetic outcomes of postoperative high-dose-rate interventional radiotherapy (HDR-IRT) in patients affected by conjunctival melanoma with orbit invasion. METHODS: A retrospective study was conducted in 2 patients affected by conjunctival melanoma infiltrating the orbit, treated with surgical excision and HDR-IRT. The treatment procedures consisted of surgical excision of the orbital infiltrating nodule followed, 1 month after surgery, by adjuvant HDR-IRT. A target dose of 34 Gy was delivered in 10 twice-a-day fractions over 5 consecutive days. Data analysis included local tumor control and metastatic rate, acute and late toxicity, functional and aesthetic results. RESULTS: In both patients, treatment was well tolerated, and there was no orbital recurrence at a median follow-up of 37-40 months. There was an excellent functional outcome, without no significant acute or late side effects. CONCLUSIONS: HDR-IRT could be considered a promising, feasible, successful, and well-tolerated option for selected patients affected by ocular tumors with orbital invasion.
PURPOSE: To evaluate local control and functional and cosmetic outcomes of postoperative high-dose-rate interventional radiotherapy (HDR-IRT) in patients affected by conjunctival melanoma with orbit invasion. METHODS: A retrospective study was conducted in 2 patients affected by conjunctival melanoma infiltrating the orbit, treated with surgical excision and HDR-IRT. The treatment procedures consisted of surgical excision of the orbital infiltrating nodule followed, 1 month after surgery, by adjuvant HDR-IRT. A target dose of 34 Gy was delivered in 10 twice-a-day fractions over 5 consecutive days. Data analysis included local tumor control and metastatic rate, acute and late toxicity, functional and aesthetic results. RESULTS: In both patients, treatment was well tolerated, and there was no orbital recurrence at a median follow-up of 37-40 months. There was an excellent functional outcome, without no significant acute or late side effects. CONCLUSIONS: HDR-IRT could be considered a promising, feasible, successful, and well-tolerated option for selected patients affected by ocular tumors with orbital invasion.
Authors: Luca Tagliaferri; Francesco Bussu; Bruno Fionda; Francesco Catucci; Mario Rigante; Maria Antonietta Gambacorta; Rosa Autorino; Gian Carlo Mattiucci; Francesco Miccichè; Elisa Placidi; Mario Balducci; Jacopo Galli; Gaetano Paludetti; György Kovacs; Vincenzo Valentini Journal: Tumori Date: 2017-03-08 Impact factor: 2.098
Authors: Michael Chang; Sara E Lally; Lauren A Dalvin; Marlana M Orloff; Carol L Shields Journal: Indian J Ophthalmol Date: 2019-12 Impact factor: 1.848