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Literature DB >> 25580155

Management of conjunctival malignant melanoma: a review and update.

James R Wong¹, Afshan A Nanji¹, Anat Galor², Carol L Karp¹.

Abstract

Conjunctival malignant melanoma is a pigmented lesion of the ocular surface. It is an uncommon but potentially devastating tumor that may invade the local tissues of the eye, spread systemically through lymphatic drainage and hematogenous spread, and recur in spite of treatment. Despite its severity, the rarity of available cases has limited the evidence for diagnosis and management. This review will provide an overview of the epidemiology, presentation, diagnosis, management, and surveillance of conjunctival melanoma, with an emphasis on recent advances in biological therapies to treat this disease.

Entities: Chemical Disease Gene Mutation Species

Keywords: BRAF inhibitors; Conjunctival malignant melanoma; dabrafenib; interferon alpha-2b; ipilimumab; melanoma; mitomycin C; ocular neoplasm; vemurafenib

Year: 2014 PMID： 25580155 PMCID： PMC4285629 DOI： 10.1586/17469899.2014.921119

Source DB: PubMed Journal: Expert Rev Ophthalmol ISSN： 1746-9899

166 in total

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Journal: Br J Ophthalmol Date: 1992-04 Impact factor: 4.638

2. Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses.

Authors: Stergios J Moschos; Howard D Edington; Stephanie R Land; Uma N Rao; Drazen Jukic; Janice Shipe-Spotloe; John M Kirkwood
Journal: J Clin Oncol Date: 2006-07-01 Impact factor: 44.544

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Journal: Arch Ophthalmol Date: 1997-06

4. Long-term follow-up of patients with conjunctival melanoma.

Authors: Cornelia Werschnik; Peter K Lommatzsch
Journal: Am J Clin Oncol Date: 2002-06 Impact factor: 2.339

5. Malignant melanoma of the conjunctiva.

Authors: R Folberg; I W McLean; L E Zimmerman
Journal: Hum Pathol Date: 1985-02 Impact factor: 3.466

6. Liquid nitrogen cryotherapy for surface eye disease (an AOS thesis).

Authors: Frederick Web Fraunfelder
Journal: Trans Am Ophthalmol Soc Date: 2008

7. Conjunctival melanoma: is it increasing in the United States?

Authors: Guo-Pei Yu; Dan-Nin Hu; Steven McCormick; Paul T Finger
Journal: Am J Ophthalmol Date: 2003-06 Impact factor: 5.258

8. Whole-body 18 FDG PET/CT imaging for lymph node and metastatic staging of conjunctival melanoma.

Authors: M Kurli; K Chin; P T Finger
Journal: Br J Ophthalmol Date: 2008-04 Impact factor: 4.638

Review 9. Malignant melanoma in the 21st century: the emerging molecular landscape.

Authors: Aleksandar Sekulic; Paul Haluska; Arlo J Miller; Josep Genebriera De Lamo; Samuel Ejadi; Jose S Pulido; Diva R Salomao; Erik C Thorland; Richard G Vile; David L Swanson; Barbara A Pockaj; Susan D Laman; Mark R Pittelkow; Svetomir N Markovic
Journal: Mayo Clin Proc Date: 2008-07 Impact factor: 7.616

10. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma.

Authors: Nancy E Thomas; Sharon N Edmiston; Audrey Alexander; Robert C Millikan; Pamela A Groben; Honglin Hao; Dawn Tolbert; Marianne Berwick; Klaus Busam; Colin B Begg; Dianne Mattingly; David W Ollila; Chiu Kit Tse; Amanda Hummer; Julia Lee-Taylor; Kathleen Conway
Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-05 Impact factor: 4.254

38 in total

1. Spontaneous regression of conjunctival keratoacanthoma.

Authors: Ghada J AlBayyat; Nandini Venkateswaran; Dan Arreaza; Sander R Dubovy; Anat Galor; Carol L Karp
Journal: BMJ Case Rep Date: 2019-07-11

2. Molecular Characteristics of Conjunctival Melanoma Using Whole-Exome Sequencing.

Authors: Swarup S Swaminathan; Matthew G Field; David Sant; Gaofeng Wang; Anat Galor; Sander R Dubovy; J William Harbour; Carol L Karp
Journal: JAMA Ophthalmol Date: 2017-12-01 Impact factor: 7.389

3. Incidence of orbital, conjunctival and lacrimal gland malignant tumors in USA from Surveillance, Epidemiology and End Results, 1973-2009.

Authors: Waleed M Hassan; Mohamed S Bakry; Housam M Hassan; Ahmad S Alfaar
Journal: Int J Ophthalmol Date: 2016-12-18 Impact factor: 1.779

Management of conjunctival malignant melanoma: a review and update.

1. Impression cytology of conjunctival melanosis and melanoma.

2. Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses.

Review 3. Surgical management of conjunctival tumors. The 1994 Lynn B. McMahan Lecture.

4. Long-term follow-up of patients with conjunctival melanoma.

5. Malignant melanoma of the conjunctiva.

6. Liquid nitrogen cryotherapy for surface eye disease (an AOS thesis).

7. Conjunctival melanoma: is it increasing in the United States?

8. Whole-body 18 FDG PET/CT imaging for lymph node and metastatic staging of conjunctival melanoma.

Review 9. Malignant melanoma in the 21st century: the emerging molecular landscape.

10. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma.

1. Spontaneous regression of conjunctival keratoacanthoma.

2. Molecular Characteristics of Conjunctival Melanoma Using Whole-Exome Sequencing.

3. Incidence of orbital, conjunctival and lacrimal gland malignant tumors in USA from Surveillance, Epidemiology and End Results, 1973-2009.

4. Conjunctival melanoma: association of cyclooxygenase-2 tumor expression to prognosis.

Review 5. Conjunctival Melanoma - Epidemiological Trends and Features.

6. Handheld In Vivo Reflectance Confocal Microscopy for the Diagnosis of Eyelid Margin and Conjunctival Tumors.

7. Immunotherapy With Programmed Cell Death 1 Inhibitors for 5 Patients With Conjunctival Melanoma.

8. Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma.

Review 9. Conjunctival Melanoma in Childhood and Adolescence: A Systematic Review.

10. Conjunctival Metastasis of a Cutaneous Melanoma.