Lishu Gao1, Jian Xie1, Tingting Huang1, Yushan Shang1, Zhihan Gao1. 1. Department of Clinical Psychology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang Province, China.
Abstract
OBJECTIVE: To explore the clinical effects of mindfulness decompression therapy combined with transcranial magnetic stimulation in generalized anxiety disorder. METHODS: In the present prospective study, ninety-two patients with generalized anxiety disorder were randomly divided into two groups, with 46 cases in each group. On the basis of drug treatment, patients in the control group received transcranial magnetic stimulation, and patients in the research group were treated with mindfulness decompression therapy combined with transcranial magnetic stimulation. The total effective rate, anxiety degree (evaluated by the Hamilton Anxiety Scale (HAMA) score), severity of condition (evaluated by the clinical global impression (CGI) score), comfort degree score (Psychology, physiology, environment, social culture), neuroelectrophysiological parameters and sleep quality (Pittsburgh sleep quality index (PSQI) factors) before and after treatment were compared between the two groups. RESULTS: After treatment, the research group had higher total effective rate than that of the control group (P<0.05); the HAMA score and CGI score of two groups were both decreased, and the research group decreased much more than the control group (P<0.05); mismatch negativity (MMN) latency, target N2 latency and target P3 latency of two groups were all decreased, MMN amplitude and none-target P2 amplitude were both increased, and the research group improved much more than the control group (P<0.05); the scores of social comfort, environmental comfort, physiological comfort and psychological comfort of two groups were all increased, and the corresponding scores of the research group were all higher than those of the control group (P<0.05); PSQI scores of two groups were all decreased, and the research group had lower PSQI scores than the control group (P<0.05). CONCLUSION:Mindfulness decompression therapy combined with transcranial magnetic stimulation effectively relieve anxiety symptoms and improve comfort degree and sleep quality in patients with generalized anxiety disorder. AJTR
RCT Entities:
OBJECTIVE: To explore the clinical effects of mindfulness decompression therapy combined with transcranial magnetic stimulation in generalized anxiety disorder. METHODS: In the present prospective study, ninety-two patients with generalized anxiety disorder were randomly divided into two groups, with 46 cases in each group. On the basis of drug treatment, patients in the control group received transcranial magnetic stimulation, and patients in the research group were treated with mindfulness decompression therapy combined with transcranial magnetic stimulation. The total effective rate, anxiety degree (evaluated by the Hamilton Anxiety Scale (HAMA) score), severity of condition (evaluated by the clinical global impression (CGI) score), comfort degree score (Psychology, physiology, environment, social culture), neuroelectrophysiological parameters and sleep quality (Pittsburgh sleep quality index (PSQI) factors) before and after treatment were compared between the two groups. RESULTS: After treatment, the research group had higher total effective rate than that of the control group (P<0.05); the HAMA score and CGI score of two groups were both decreased, and the research group decreased much more than the control group (P<0.05); mismatch negativity (MMN) latency, target N2 latency and target P3 latency of two groups were all decreased, MMN amplitude and none-target P2 amplitude were both increased, and the research group improved much more than the control group (P<0.05); the scores of social comfort, environmental comfort, physiological comfort and psychological comfort of two groups were all increased, and the corresponding scores of the research group were all higher than those of the control group (P<0.05); PSQI scores of two groups were all decreased, and the research group had lower PSQI scores than the control group (P<0.05). CONCLUSION: Mindfulness decompression therapy combined with transcranial magnetic stimulation effectively relieve anxiety symptoms and improve comfort degree and sleep quality in patients with generalized anxiety disorder. AJTR
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