Zhaoyang Huang1, Yue Li2, Matt T Bianchi3, Shuqin Zhan4, Fengying Jiang4, Ning Li4, Yan Ding4, Yue Hou4, Li Wang4, Quping Ouyang5, Yuping Wang6. 1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. 2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China; Department of Neurology, Beijing Shunyi Hospital, Beijing, China. 3. Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. 4. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China. 5. Department of Neurology, Beijing Shunyi Hospital, Beijing, China. 6. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China. Electronic address: mdwangyp@sina.cn.
Abstract
BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has been considered to be a promising technique for the treatment of neuropsychiatric disorders. However, little is known about the effectiveness of rTMS in the treatment of generalized anxiety disorder (GAD). Moreover, treatment data on comorbid GAD and insomnia remain lacking. The aim of this study was to examine the therapeutic effects of 1 Hz rTMS applied over the right parietal lobe on both anxiety and insomnia symptoms in patients with comorbid GAD and insomnia. METHODS:36 patients were randomized to either sham or active rTMS group (n = 18 each group). The rTMS was administered over the right posterior parietal cortex (P4 electrode site) at a frequency of 1 Hz and an intensity of 90% of the resting motor threshold. RESULTS: Ten days of 1 Hz rTMS to the right parietal lobe significantly improved both anxiety and insomnia symptoms in the active group. Although the anxiety severity was not significantly correlated with insomnia severity at baseline, the improvement in the Hamilton Rating Scale for Anxiety (HRSA) scores were positively correlated with improvement in the Pittsburgh Sleep Quality Index (PSQI) scores. CONCLUSIONS: The present study is the first randomized sham-controlled study to assess the effectiveness of low frequency rTMS on the right parietal lobe in patients with comorbid GAD and insomnia. Our results suggested that 1 Hz low frequency rTMS administered over the parietal cortex is effective for both anxiety and insomnia symptoms in patients with comorbid GAD and insomnia.
RCT Entities:
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been considered to be a promising technique for the treatment of neuropsychiatric disorders. However, little is known about the effectiveness of rTMS in the treatment of generalized anxiety disorder (GAD). Moreover, treatment data on comorbid GAD and insomnia remain lacking. The aim of this study was to examine the therapeutic effects of 1 Hz rTMS applied over the right parietal lobe on both anxiety and insomnia symptoms in patients with comorbid GAD and insomnia. METHODS: 36 patients were randomized to either sham or active rTMS group (n = 18 each group). The rTMS was administered over the right posterior parietal cortex (P4 electrode site) at a frequency of 1 Hz and an intensity of 90% of the resting motor threshold. RESULTS: Ten days of 1 Hz rTMS to the right parietal lobe significantly improved both anxiety and insomnia symptoms in the active group. Although the anxiety severity was not significantly correlated with insomnia severity at baseline, the improvement in the Hamilton Rating Scale for Anxiety (HRSA) scores were positively correlated with improvement in the Pittsburgh Sleep Quality Index (PSQI) scores. CONCLUSIONS: The present study is the first randomized sham-controlled study to assess the effectiveness of low frequency rTMS on the right parietal lobe in patients with comorbid GAD and insomnia. Our results suggested that 1 Hz low frequency rTMS administered over the parietal cortex is effective for both anxiety and insomnia symptoms in patients with comorbid GAD and insomnia.
Authors: A Irem Sonmez; M Utku Kucuker; Charles P Lewis; Bhanu Prakash Kolla; Deniz Doruk Camsari; Jennifer L Vande Voort; Kathryn M Schak; Simon Kung; Paul E Croarkin Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2019-10-18 Impact factor: 5.067
Authors: Alberto Herrero Babiloni; Beatrice P De Koninck; Gabrielle Beetz; Louis De Beaumont; Marc O Martel; Gilles J Lavigne Journal: J Neural Transm (Vienna) Date: 2019-08-26 Impact factor: 3.575
Authors: Gay Florian; Allison Singier; Bruno Aouizerate; Francesco Salvo; Thomas C M Bienvenu Journal: Front Psychiatry Date: 2022-07-01 Impact factor: 5.435
Authors: Vitor Iglesias Mangolini; Laura Helena Andrade; Francisco Lotufo-Neto; Yuan-Pang Wang Journal: Clinics (Sao Paulo) Date: 2019-11-11 Impact factor: 2.365