Green synthesis of some 3-(α,α-diarylmethyl)indoles by bio-nanocomposite from embedding L-histidinium trichloroacetate ionic liquid on functionalized magnetite (L-His+CCl3CO2-@PEG@SiO2-nano Fe3O4).

In this research, a new multilayered magnetized bio-nanocomposite has been prepared. At first, the amino acid-based ionic liquid was obtained from L-histidine and trichloroacetic acid (L-His+CCl3CO2-), embedded on the polyethylene glycol-functionalized silicated-nanomagnetite, to prepare the final nanostructure (L-His+CCl3CO2-@PEG@SiO2-nano Fe3O4). The bio-nanocomposite was characterized by several techniques such as FT-IR, FESEM, TGA/DTG, EDAX, TEM, VSM, and XRD. The catalytic activity of the core-shell nanostructure was examined in one-pot three-component reaction between aryl aldehydes, indoles, and β-naphthol/phenols to get some new 3-(α,α-diarylmethyl)indoles under solvent-free conditions at 75 °C. Eco-friendly protocol in the absence of hazardous solvents, no observation of by-products such as bis(indolyl)methanes (BIMs), in addition to recovery and reusability of the nanostructure within 3 runs without activity loss are some highlighted notable features of the work. The reused bio-nanocomposite was also characterized through FESEM technique.