Literature DB >> 34292511

The Tangled Knots of Neuroscientific Experimentation.

Stefan Frisch1,2.   

Abstract

The experimental method has promoted the popularity of neuroscientific research on the human mind. In this interdisciplinary enterprise, the experimental method, with its roots in natural science and experimental psychology, is often uncritically accepted as the royal road to investigate the human mind not only by neuroscientists, but by many philosophers as well, especially those inclined to some form of naturalism. It is rarely disputed that experiments reveal actual states of nature (here: of mind and/or brain). Experimental results are used to picture the human person or subject as an illusionary construct resulting from neuronal interactions. The present paper sketches some of the limitations of neuroscientific experiments in order to demonstrate that cognitive neuroscience is far from relying on firm methodological grounds. Numerous issues still have to be solved, some of which date back to the early days of modern science. At least, to make experiments work, many theoretical presuppositions have to be accepted and decisions of relevance have to be made in the scientific process. This implies that all scientific endeavor is constituted by persons making free decisions for good reasons, despite all reductionist claims to the contrary. The fact that we as scientists have to distinguish relevant from irrelevant aspects of experimental procedures is also crucial for dealing with the current replicability crisis in the life sciences including neuroscience.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Experiment; Naturalism; Neuroscience; Organism; Replicability

Year:  2021        PMID: 34292511     DOI: 10.1007/s12124-021-09617-9

Source DB:  PubMed          Journal:  Integr Psychol Behav Sci        ISSN: 1932-4502


  28 in total

1.  Drug development: Raise standards for preclinical cancer research.

Authors:  C Glenn Begley; Lee M Ellis
Journal:  Nature       Date:  2012-03-28       Impact factor: 49.962

Review 2.  How reliable are the results from functional magnetic resonance imaging?

Authors:  Craig M Bennett; Michael B Miller
Journal:  Ann N Y Acad Sci       Date:  2010-03       Impact factor: 5.691

3.  Robust research: Institutions must do their part for reproducibility.

Authors:  C Glenn Begley; Alastair M Buchan; Ulrich Dirnagl
Journal:  Nature       Date:  2015-09-03       Impact factor: 49.962

4.  Albrecht von Haller (1708-1777).

Authors:  E Frixione
Journal:  J Neurol       Date:  2006-02       Impact factor: 4.849

5.  Empirical evidence for low reproducibility indicates low pre-study odds.

Authors:  Katherine S Button; John P A Ioannidis; Claire Mokrysz; Brian A Nosek; Jonathan Flint; Emma S J Robinson; Marcus R Munafò
Journal:  Nat Rev Neurosci       Date:  2013-10-23       Impact factor: 34.870

6.  Reproducibility: The risks of the replication drive.

Authors:  Mina Bissell
Journal:  Nature       Date:  2013-11-21       Impact factor: 49.962

Review 7.  Building Blocks of Psychology: on Remaking the Unkept Promises of Early Schools.

Authors:  Davood G Gozli; Wei Sophia Deng
Journal:  Integr Psychol Behav Sci       Date:  2018-03

8.  "Positive" results increase down the Hierarchy of the Sciences.

Authors:  Daniele Fanelli
Journal:  PLoS One       Date:  2010-04-07       Impact factor: 3.240

Review 9.  Are Mental Disorders Brain Diseases, and What Does This Mean? A Clinical-Neuropsychological Perspective.

Authors:  Stefan Frisch
Journal:  Psychopathology       Date:  2016-07-19       Impact factor: 1.944

10.  Reducing mouse anxiety during handling: effect of experience with handling tunnels.

Authors:  Kelly Gouveia; Jane L Hurst
Journal:  PLoS One       Date:  2013-06-20       Impact factor: 3.240

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  1 in total

1.  Why Biological Psychiatry Hasn't Delivered Yet - and Why Neurology Knows.

Authors:  Stefan Frisch
Journal:  Psychiatry Investig       Date:  2021-12-08       Impact factor: 2.505

  1 in total

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