Joseph N Badaoui1, Todd A Kellogg1, Barham K Abu Dayyeh2, Justin W Maroun1, Travis J McKenzie1, William S Harmsen3, Michael L Kendrick1, Omar M Ghanem4,5. 1. Department of Surgery, Mayo Clinic, Rochester, MN, USA. 2. Department of Medicine, Mayo Clinic, Rochester, MN, USA. 3. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 4. Department of Surgery, Mayo Clinic, Rochester, MN, USA. Ghanem.Omar@mayo.edu. 5. Division of Endocrine & Metabolic Surgery, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Ghanem.Omar@mayo.edu.
Abstract
PURPOSE: The outcomes of laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) on gastro-esophageal reflux disease (GERD) are not well elucidated. MATERIAL/ METHODS: This retrospective review included patients undergoing laparoscopic primary BPD-DS at Mayo Clinic from 2009 to 2019. GERD parameters analyzed included subjective symptom report/anti-reflux medication intake and/or endoscopic findings. GERD-HRQL questionnaire was also utilized post-operatively. Three subgroups were employed to stratify patients depending on GERD outcomes: the "No-effect" subgroup included patients where surgery did not affect either positively (GERD resolution) or negatively (de novo GERD) GERD outcome, "De novo GERD" subgroup, and "GERD-resolved" subgroup. Multinomial logistic modeling was used to examine associations with the 3-level GERD subgroup (p<0.05). RESULTS: Seventy-six patients were included in the analysis. Thirty-four (44.7%) patients were found to be in the "GERD-resolved" subgroup, 28 (36.8%) patients in the "No-effect" subgroup, and 14 (18.4%) patients in the "De novo GERD" subgroup. Multinomial logistic modeling showed that patients with pre-surgery diabetes mellitus (DM) had lesser odds (OR= 0.248, (95% CI: 0.085-0.724, p=0.0108)) of GERD resolution than patients without pre-surgery DM. An association was also established between %TWL at 6 and 12 months following the procedure and GERD outcome (p=0.017 and 0.008, respectively). Finally, the mean (SD) post-operative GERD-HRQL score was 8.7 (8.1) points, and 69 (91%) patients were currently satisfied with their post-operative condition. CONCLUSION: Laparoscopic BPD-DS appears to have a satisfactory GERD outcome in most patients undergoing the operation. There appears to be an association between pre-operative DM, %TWL at 6 and 12 months, and GERD prognosis in this population.
PURPOSE: The outcomes of laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) on gastro-esophageal reflux disease (GERD) are not well elucidated. MATERIAL/ METHODS: This retrospective review included patients undergoing laparoscopic primary BPD-DS at Mayo Clinic from 2009 to 2019. GERD parameters analyzed included subjective symptom report/anti-reflux medication intake and/or endoscopic findings. GERD-HRQL questionnaire was also utilized post-operatively. Three subgroups were employed to stratify patients depending on GERD outcomes: the "No-effect" subgroup included patients where surgery did not affect either positively (GERD resolution) or negatively (de novo GERD) GERD outcome, "De novo GERD" subgroup, and "GERD-resolved" subgroup. Multinomial logistic modeling was used to examine associations with the 3-level GERD subgroup (p<0.05). RESULTS: Seventy-six patients were included in the analysis. Thirty-four (44.7%) patients were found to be in the "GERD-resolved" subgroup, 28 (36.8%) patients in the "No-effect" subgroup, and 14 (18.4%) patients in the "De novo GERD" subgroup. Multinomial logistic modeling showed that patients with pre-surgery diabetes mellitus (DM) had lesser odds (OR= 0.248, (95% CI: 0.085-0.724, p=0.0108)) of GERD resolution than patients without pre-surgery DM. An association was also established between %TWL at 6 and 12 months following the procedure and GERD outcome (p=0.017 and 0.008, respectively). Finally, the mean (SD) post-operative GERD-HRQL score was 8.7 (8.1) points, and 69 (91%) patients were currently satisfied with their post-operative condition. CONCLUSION: Laparoscopic BPD-DS appears to have a satisfactory GERD outcome in most patients undergoing the operation. There appears to be an association between pre-operative DM, %TWL at 6 and 12 months, and GERD prognosis in this population.
Authors: Hashem B El-Serag; Ali Hashmi; Jose Garcia; Peter Richardson; Abeer Alsarraj; Stephanie Fitzgerald; Marcelo Vela; Yasser Shaib; Neena S Abraham; Maria Velez; Rhonda Cole; Margot B Rodriguez; Bhupinderjit Anand; David Y Graham; Jennifer R Kramer Journal: Gut Date: 2013-02-13 Impact factor: 23.059
Authors: Ray Portela; Katie Marrerro; Ahmet Vahibe; Carlos Galvani; Helmuth Billy; Barham Abu Dayyeh; Benjamin Clapp; Omar M Ghanem Journal: Obes Surg Date: 2022-02-09 Impact factor: 3.479