Alžbeta Čagalová1, Ľubica Tichá1, Alexandra Gaál Kovalčíková1, Katarína Šebeková2, Ľudmila Podracká3. 1. Department of Pediatrics, Faculty of Medicine, National Institute of Children's Diseases, Comenius University, Limbová 1, 833 40, Bratislava, Slovakia. 2. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia. 3. Department of Pediatrics, Faculty of Medicine, National Institute of Children's Diseases, Comenius University, Limbová 1, 833 40, Bratislava, Slovakia. podracka12@yahoo.com.
Abstract
Oxidative stress appears to be involved in the pathogenesis of osteoporosis-a serious complication of anorexia nervosa (AN). We evaluated the oxidative status in adolescent girls with AN and its potential relationship with bone mineral density (BMD). Girls with AN (n = 43) and age-matched healthy controls (n = 20) underwent anthropometric and BMD examination. Markers of bone turnover, oxidative stress, and antioxidant status were measured. Participants with AN and controls did not differ in BMD at the lumbar spine (p = 0.17) and total body less head BMD (p = 0.08). BMD at the total hip was lower (p < 0.001) in the AN group compared with the controls. Levels of antioxidant status markers-ferric reduction antioxidant power, total antioxidant capacity, and reduced and oxidized glutathione ratio (all p < 0.001)-were significantly lower, whereas those of advanced oxidation protein products (AOPP), fructosamines, and advanced glycation end products (AGEs) (all p < 0.001) were higher in AN patients than in healthy controls. BMD and bone turnover markers were positively correlated with antioxidant status markers, while they were negatively correlated with AOPP, fructosamines, and AGEs levels. Conclusion: This is the first study to assess a potential association between oxidative status and BMD in adolescents with AN. We demonstrated that in young girls, the imbalance of oxidative status and reduced BMD are concurrently manifested at the time of the diagnosis of AN. Disturbance of oxidative status could play a pathogenetic role in AN-associated decreased BMD. What is Known: • Osteoporosis is a serious complication of AN, and in affected adolescents may result in a permanent deficit in bone mass. • Oxidative and carbonyl stress may be involved in the development of bone loss. What is New: • Adolescents girls with AN have impaired antioxidant defense and increased oxidative damage to biomolecules. • Disturbance of oxidative status could affect bone loss and could contribute to decreased BMD in adolescent females with AN.
Oxidative stress appears to be involved in the pathogenesis of osteoporosis-a serious complication of anorexia nervosa (AN). We evaluated the oxidative status in adolescent girls with AN and its potential relationship with bone mineral density (BMD). Girls with AN (n = 43) and age-matched healthy controls (n = 20) underwent anthropometric and BMD examination. Markers of bone turnover, oxidative stress, and antioxidant status were measured. Participants with AN and controls did not differ in BMD at the lumbar spine (p = 0.17) and total body less head BMD (p = 0.08). BMD at the total hip was lower (p < 0.001) in the AN group compared with the controls. Levels of antioxidant status markers-ferric reduction antioxidant power, total antioxidant capacity, and reduced and oxidized glutathione ratio (all p < 0.001)-were significantly lower, whereas those of advanced oxidation protein products (AOPP), fructosamines, and advanced glycation end products (AGEs) (all p < 0.001) were higher in AN patients than in healthy controls. BMD and bone turnover markers were positively correlated with antioxidant status markers, while they were negatively correlated with AOPP, fructosamines, and AGEs levels. Conclusion: This is the first study to assess a potential association between oxidative status and BMD in adolescents with AN. We demonstrated that in young girls, the imbalance of oxidative status and reduced BMD are concurrently manifested at the time of the diagnosis of AN. Disturbance of oxidative status could play a pathogenetic role in AN-associated decreased BMD. What is Known: • Osteoporosis is a serious complication of AN, and in affected adolescents may result in a permanent deficit in bone mass. • Oxidative and carbonyl stress may be involved in the development of bone loss. What is New: • Adolescents girls with AN have impaired antioxidant defense and increased oxidative damage to biomolecules. • Disturbance of oxidative status could affect bone loss and could contribute to decreased BMD in adolescent females with AN.
Authors: Marco Solmi; Nicola Veronese; Enzo Manzato; Giuseppe Sergi; Angela Favaro; Paolo Santonastaso; Christoph U Correll Journal: Int J Eat Disord Date: 2015-08-27 Impact factor: 4.861
Authors: Marian Valko; Dieter Leibfritz; Jan Moncol; Mark T D Cronin; Milan Mazur; Joshua Telser Journal: Int J Biochem Cell Biol Date: 2006-08-04 Impact factor: 5.085
Authors: C M Hadigan; E J Anderson; K K Miller; J L Hubbard; D B Herzog; A Klibanski; S K Grinspoon Journal: Int J Eat Disord Date: 2000-11 Impact factor: 4.861
Authors: Leslie A Soyka; Madhusmita Misra; Aparna Frenchman; Karen K Miller; Steven Grinspoon; David A Schoenfeld; Anne Klibanski Journal: J Clin Endocrinol Metab Date: 2002-09 Impact factor: 5.958
Authors: Kristina Podolakova; Lubomir Barak; Emilia Jancova; Juraj Stanik; Katarina Sebekova; Ludmila Podracka Journal: Int J Environ Res Public Health Date: 2022-09-21 Impact factor: 4.614