Yara Ahmed Mohamed1, H M Hassaneen2, Mohamed A El-Dessouky3, Gehan Safwat4, Naglaa Abu-Mandil Hassan5, Khalda Amr6. 1. Faculty of Biotechnology, October University for Modern Sciences and Arts University (MSA), No. 12567, 54 Anwar El-Sadat street, Al-Haram, Giza, Egypt. ymuhammed@msa.edu.eg. 2. Faculty of Science, Chemistry Department, Cairo University, Giza, Egypt. 3. Faculty of Science, Biochemistry Division, Cairo University, Giza, Egypt. 4. Faculty of Biotechnology, October University for Modern Sciences and Arts University (MSA), No. 12567, 54 Anwar El-Sadat street, Al-Haram, Giza, Egypt. 5. Medical Research Division, Biological Anthropology Department, National Research Centre, Giza, Egypt. 6. Human Genetics and Genome Research Division, Medical Molecular Genetics Department, National Research Centre, Giza, Egypt.
Abstract
BACKGROUND: A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian. MATERIALS AND METHODS: A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR. RESULTS: We observed marked overexpression in DYRK1B (p < 0.05) in MetS subjects when compared with the healthy control subjects. CONCLUSION: This is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.
BACKGROUND: A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian. MATERIALS AND METHODS: A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR. RESULTS: We observed marked overexpression in DYRK1B (p < 0.05) in MetS subjects when compared with the healthy control subjects. CONCLUSION: This is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.
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