| Literature DB >> 34291178 |
Maxim E Sergeev1,2, Mark Lazari1,2,3, Federica Morgia1,2, Jeffrey Collins1,2, Muhammad Rashed Javed1,2, Olga Sergeeva1,2, Jason Jones4, Michael E Phelps1,2,5, Jason T Lee1,2,5, Pei Yuin Keng1,2,5, R Michael van Dam1,2,3,4,5.
Abstract
Positron emission tomography (PET) is a molecular diagnostic imaging technology to quantitatively visualize biological processes in vivo. For many applications, including imaging of low tissue density targets (e.g. neuroreceptors), imaging in small animals, and evaluation of novel tracers, the injected PET tracer must be produced with high molar activity to ensure low occupancy of biological targets and avoid pharmacologic effects. Additionally, high molar activity is essential for tracers with lengthy syntheses or tracers transported to distant imaging sites. We show that radiosynthesis of PET tracers in microliter volumes instead of conventional milliliter volumes results in substantially increased molar activity, and we identify the most relevant variables affecting this parameter. Furthermore, using the PET tracer [18F]fallypride, we illustrate that molar activity can have a significant impact on biodistribution. With full automation, microdroplet platforms could provide a means for radiochemists to routinely, conveniently, and safely produce PET tracers with high molar activity.Year: 2018 PMID： 34291178 PMCID： PMC8291036 DOI： 10.1038/s42004-018-0009-z
Source DB: PubMed Journal: Commun Chem ISSN： 2399-3669