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Literature DB >> 34287997

Suppressing toxic aggregates: let MIA do it!

Urszula Nowicka¹, Min-Ji Kim^1,2, Agnieszka Chacinska^1,2,3.

Abstract

Mitochondrial activity is becoming an inherent aspect of cellular protein homeostasis (proteostasis). In this issue, Schlagowski et al (2021) report on the attractive notion that modulating mitochondrial protein import activity stimulates protein aggregate clearance in the cytosol, thereby affecting cytosolic proteostasis and its collapse observed in neurodegenerative diseases.

Entities: Chemical

Mesh：

Substances：
Mitochondrial Proteins

Year: 2021 PMID： 34287997 PMCID： PMC8365259 DOI： 10.15252/embj.2021109001

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 14.012

13 in total

1. MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress.

Authors: Hilla Weidberg; Angelika Amon
Journal: Science Date: 2018-04-12 Impact factor: 47.728

2. Cytosolic Protein Vms1 Links Ribosome Quality Control to Mitochondrial and Cellular Homeostasis.

Authors: Toshiaki Izawa; Sae-Hun Park; Liang Zhao; F Ulrich Hartl; Walter Neupert
Journal: Cell Date: 2017-10-26 Impact factor: 41.582

3. Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.

Authors: Urszula Nowicka; Piotr Chroscicki; Karen Stroobants; Maria Sladowska; Michal Turek; Barbara Uszczynska-Ratajczak; Rishika Kundra; Tomasz Goral; Michele Perni; Christopher M Dobson; Michele Vendruscolo; Agnieszka Chacinska
Journal: Elife Date: 2021-07-20 Impact factor: 8.140

4. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging.

Authors: Johnathan Labbadia; Renee M Brielmann; Mario F Neto; Yi-Fan Lin; Cole M Haynes; Richard I Morimoto
Journal: Cell Rep Date: 2017-11-07 Impact factor: 9.423

5. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol.

Authors: Lidia Wrobel; Ulrike Topf; Piotr Bragoszewski; Sebastian Wiese; Malgorzata E Sztolsztener; Silke Oeljeklaus; Aksana Varabyova; Maciej Lirski; Piotr Chroscicki; Seweryn Mroczek; Elzbieta Januszewicz; Andrzej Dziembowski; Marta Koblowska; Bettina Warscheid; Agnieszka Chacinska
Journal: Nature Date: 2015-08-05 Impact factor: 49.962

6. Mitochondrial protein translocation-associated degradation.

Authors: Chantal Priesnitz; Jiyao Song; Christoph U Mårtensson; Lars Ellenrieder; Kim Nguyen Doan; Felix Boos; Alessia Floerchinger; Nicole Zufall; Silke Oeljeklaus; Bettina Warscheid; Thomas Becker
Journal: Nature Date: 2019-05-22 Impact factor: 49.962

Review 7. Mitochondrial proteins: from biogenesis to functional networks.

Authors: Nikolaus Pfanner; Bettina Warscheid; Nils Wiedemann
Journal: Nat Rev Mol Cell Biol Date: 2019-05 Impact factor: 94.444

8. Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol.

Authors: Anna M Schlagowski; Katharina Knöringer; Sandrine Morlot; Ana Sánchez Vicente; Tamara Flohr; Lena Krämer; Felix Boos; Nabeel Khalid; Sheraz Ahmed; Jana Schramm; Lena M Murschall; Per Haberkant; Frank Stein; Jan Riemer; Benedikt Westermann; Ralf J Braun; Konstanze F Winklhofer; Gilles Charvin; Johannes M Herrmann
Journal: EMBO J Date: 2021-06-30 Impact factor: 11.598

9. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans.

Authors: Maria Sladowska; Michał Turek; Min-Ji Kim; Krzysztof Drabikowski; Ben Hur Marins Mussulini; Karthik Mohanraj; Remigiusz A Serwa; Ulrike Topf; Agnieszka Chacinska
Journal: PLoS Biol Date: 2021-07-12 Impact factor: 8.029

10. Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Authors: Vincenzo Sorrentino; Mario Romani; Laurent Mouchiroud; John S Beck; Hongbo Zhang; Davide D'Amico; Norman Moullan; Francesca Potenza; Adrien W Schmid; Solène Rietsch; Scott E Counts; Johan Auwerx
Journal: Nature Date: 2017-12-06 Impact factor: 49.962

1 in total

1. Suppressing toxic aggregates: let MIA do it!

Authors: Urszula Nowicka; Min-Ji Kim; Agnieszka Chacinska
Journal: EMBO J Date: 2021-07-20 Impact factor: 14.012

1 in total