Nurullah Koçak1, Volkan Yeter1, Mustafa Turunç1, Merve Bayrambaş2, Bilge Eraydın3, İnci Güngör1. 1. Department of Ophthalmology, Ondokuzmayıs University Hospital, Atakum 55200, Samsun, Turkey. 2. Department of Ophthalmology, Çankırı State Hospital, Çankırı 18100, Turkey. 3. Department of Ophthalmology, Erbaa State Hospital, Tokat 60500, Turkey.
Abstract
AIM: To evaluate the atherogenic indices and the relationship with visual acuity and bilateral sequential involvement in patients with non-arteritic ischemic optic neuropathy (NAION). METHODS: A total of 65 patients with NAION and 48 age-sex matched healthy individuals were included in this retrospective study. The demographic characteristics and laboratory findings of the patients and control subjects were obtained from the electronic medical records. The atherogenic indices were calculated using the lipid parameters. The association between visual acuity, bilateral sequential involvement, and atherogenic indices was investigated. RESULTS: The mean age was 63.8±12.5y in the NAION group and 64.7±10.1y in control group (P=0.707). Although there were no significant differences in terms of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) between two groups (P=0.089, 0.091), all the non-traditional serum lipid ratios were significantly higher in NAION group (P<0.05). In the NAION subgroup analysis, with visual acuity≤20/200 had higher TC/high-density lipoprotein cholesterol (HDL-c), LDL-c/HDL-c, and non-HDL-c/HDL-c values than the patients in the NAION group with visual acuity >20/200 (P=0.032, 0.025, 0.032, respectively). The values for the atherogenic indices were higher in NAION patients with bilateral sequential involvement in comparison to those with unilateral involvement (P=0.271, 0.127, 0.197, 0.128, 0.127, respectively). CONCLUSION: The study reveals a relationship between NAION and the non-traditional lipid ratios. Atherogenic indices may predict the visual loss severity and second eye involvement in patients with NAION. International Journal of Ophthalmology Press.
AIM: To evaluate the atherogenic indices and the relationship with visual acuity and bilateral sequential involvement in patients with non-arteritic ischemic optic neuropathy (NAION). METHODS: A total of 65 patients with NAION and 48 age-sex matched healthy individuals were included in this retrospective study. The demographic characteristics and laboratory findings of the patients and control subjects were obtained from the electronic medical records. The atherogenic indices were calculated using the lipid parameters. The association between visual acuity, bilateral sequential involvement, and atherogenic indices was investigated. RESULTS: The mean age was 63.8±12.5y in the NAION group and 64.7±10.1y in control group (P=0.707). Although there were no significant differences in terms of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) between two groups (P=0.089, 0.091), all the non-traditional serum lipid ratios were significantly higher in NAION group (P<0.05). In the NAION subgroup analysis, with visual acuity≤20/200 had higher TC/high-density lipoprotein cholesterol (HDL-c), LDL-c/HDL-c, and non-HDL-c/HDL-c values than the patients in the NAION group with visual acuity >20/200 (P=0.032, 0.025, 0.032, respectively). The values for the atherogenic indices were higher in NAIONpatients with bilateral sequential involvement in comparison to those with unilateral involvement (P=0.271, 0.127, 0.197, 0.128, 0.127, respectively). CONCLUSION: The study reveals a relationship between NAION and the non-traditional lipid ratios. Atherogenic indices may predict the visual loss severity and second eye involvement in patients with NAION. International Journal of Ophthalmology Press.
Authors: E Cure; A Icli; A Ugur Uslu; R Aydoğan Baykara; D Sakiz; M Ozucan; F Yavuz; S Arslan; M Cumhur Cure; A Kucuk Journal: Z Rheumatol Date: 2017-04 Impact factor: 1.372
Authors: Philip Barter; Antonio M Gotto; John C LaRosa; Jaman Maroni; Michael Szarek; Scott M Grundy; John J P Kastelein; Vera Bittner; Jean-Charles Fruchart Journal: N Engl J Med Date: 2007-09-27 Impact factor: 91.245
Authors: Francesco U S Mattace-Raso; Tischa J M van der Cammen; Albert Hofman; Nicole M van Popele; Michiel L Bos; Maarten A D H Schalekamp; Roland Asmar; Robert S Reneman; Arnold P G Hoeks; Monique M B Breteler; Jacqueline C M Witteman Journal: Circulation Date: 2006-02-07 Impact factor: 29.690
Authors: Rohullah Sultani; David C Tong; Matthew Peverelle; Yun Suk Lee; Arul Baradi; Andrew M Wilson Journal: Heart Lung Circ Date: 2019-04-16 Impact factor: 2.975
Authors: Min Seok Kim; Han Yeong Jeong; Kwan Hyuk Cho; Seung Won Oh; Seong Jun Byun; Se Joon Woo; Hee Kyung Yang; Jeong Min Hwang; Kyu Hyung Park; Chi Kyung Kim; Sang Jun Park Journal: PLoS One Date: 2019-11-14 Impact factor: 3.240