E Cure1, A Icli2, A Ugur Uslu3, R Aydoğan Baykara4, D Sakiz5, M Ozucan2, F Yavuz6, S Arslan2, M Cumhur Cure7, A Kucuk4. 1. Recep Tayyip Erdogan University, Rize, Turkey. erkancure@yahoo.com. 2. Necmettin Erbakan University, Konya, Turkey. 3. Eskisehir Military Hospital, Eskisehir, Turkey. 4. Malatya State Hospital, Malatya, Turkey. 5. Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. 6. Dogubeyazit Docent Dr Yasar Eryilmaz State Hospital, Agri, Turkey. 7. Recep Tayyip Erdogan University, Rize, Turkey.
Abstract
OBJECTIVES: Behcet's disease (BD) is a systemic vasculitis characterized by cardiovascular complications. Early diagnosis of these complications can reduce morbidity and mortality. Carotid artery intima-media thickness (cIMT) and the logarithmic value of triglyceride to high density lipoprotein ratio (atherogenic index of plasma, AIP) are good markers of atherosclerosis. The purpose of this study was to investigate whether AIP is a predictive marker of subclinical atherosclerosis in BD patients. PATIENTS AND METHODS: A total of 84 BD patients (60 male, 24 female) and 84 healthy control individuals (58 male, 26 female) were included in this study. cIMT measurements were made, and AIP values were calculated. RESULTS: cIMT (p < 0.001) and AIP (p < 0.001) values of the BD patients were higher than those of the control group. A strong independent relationship was found between the AIP value and cIMT (β = 0.232, p = 0.018). In the subgroup analysis, the cIMT and AIP values of male BD patients were higher than those of female BD patients. CONCLUSION: Increased AIP and cIMT values can be a good marker for subclinical atherosclerosis in BD patients, especially in male BD patients.
OBJECTIVES:Behcet's disease (BD) is a systemic vasculitis characterized by cardiovascular complications. Early diagnosis of these complications can reduce morbidity and mortality. Carotid artery intima-media thickness (cIMT) and the logarithmic value of triglyceride to high density lipoprotein ratio (atherogenic index of plasma, AIP) are good markers of atherosclerosis. The purpose of this study was to investigate whether AIP is a predictive marker of subclinical atherosclerosis in BDpatients. PATIENTS AND METHODS: A total of 84 BDpatients (60 male, 24 female) and 84 healthy control individuals (58 male, 26 female) were included in this study. cIMT measurements were made, and AIP values were calculated. RESULTS: cIMT (p < 0.001) and AIP (p < 0.001) values of the BDpatients were higher than those of the control group. A strong independent relationship was found between the AIP value and cIMT (β = 0.232, p = 0.018). In the subgroup analysis, the cIMT and AIP values of male BDpatients were higher than those of female BDpatients. CONCLUSION: Increased AIP and cIMT values can be a good marker for subclinical atherosclerosis in BDpatients, especially in male BDpatients.
Entities:
Keywords:
Atherogenic index of plasma; Behçet’s disease; Carotid artery intima–media thickness; Subclinical atherosclerosis
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