Literature DB >> 3426290

Xanthine oxidoreductase is present in human synovium.

R E Allen1, J M Outhwaite, C J Morris, D R Blake.   

Abstract

It is postulated that the mobile inflamed joint may be subject to cyclical ischaemic reperfusion injury. Xanthine oxidoreductase is an enzyme thought to contribute to oxidative reperfusion injury, and the detection of this activity in human synovium is described. Three normal and five rheumatoid tissues were assayed with a carbon-14 radioassay detecting the conversion of [14C]xanthine to [14C]uric acid. Rheumatoid synovia contained 0.67-305 microU/g tissue (n = 5), while normal synovia contained 1.2-5.0 microU/g tissue (n = 3).

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Year:  1987        PMID： 3426290      PMCID： PMC1003403          DOI： 10.1136/ard.46.11.843

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  20 in total

1.  Eastern Regional Research Center Philadelphia, Pennsylvania.

Authors:  T M Dougherty
Journal:  Anal Biochem       Date:  1976-08       Impact factor: 3.365

2.  Responses of the ischemic myocardium to allopurinol.

Authors:  R A DeWall; K A Vasko; E L Stanley; P Kezdi
Journal:  Am Heart J       Date:  1971-09       Impact factor: 4.749

3.  Intra-articular pressure in rheumatoid arthritis of the knee. II. Effect of intra-articular pressure on blood circulation to the synovium.

Authors:  A J Jayson MISt Dixon
Journal:  Ann Rheum Dis       Date:  1970-05       Impact factor: 19.103

4.  Oxygen tension in synovial fluids.

Authors:  K Lund-Olesen
Journal:  Arthritis Rheum       Date:  1970 Nov-Dec

5.  Localization of xanthine oxidase acitivty in hepatic tissue. A new histochemical method.

Authors:  C Auscher; N Amory; C Pasquier; F Delbarre
Journal:  Adv Exp Med Biol       Date:  1977       Impact factor: 2.622

6.  Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium.

Authors:  E D Jarasch; C Grund; G Bruder; H W Heid; T W Keenan; W W Franke
Journal:  Cell       Date:  1981-07       Impact factor: 41.582

7.  Total ischemia in dog hearts, in vitro. 1. Comparison of high energy phosphate production, utilization, and depletion, and of adenine nucleotide catabolism in total ischemia in vitro vs. severe ischemia in vivo.

Authors:  R B Jennings; K A Reimer; M L Hill; S E Mayer
Journal:  Circ Res       Date:  1981-10       Impact factor: 17.367

8.  Direct measurement of free radical generation following reperfusion of ischemic myocardium.

Authors:  J L Zweier; J T Flaherty; M L Weisfeldt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

Review 9.  Lethal myocardial ischemic injury.

Authors:  R B Jennings; K A Reimer
Journal:  Am J Pathol       Date:  1981-02       Impact factor: 4.307

10.  The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.

Authors:  E Della Corte; F Stirpe
Journal:  Biochem J       Date:  1972-02       Impact factor: 3.766
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  15 in total

Review 1.  Drug derived radicals: mediators of the side effects of anti-inflammatory drugs?

Authors:  B Halliwell; P J Evans; H Kaur; S Chirico
Journal:  Ann Rheum Dis       Date:  1992-11       Impact factor: 19.103

Review 2.  A pathological role for damaged hyaluronan in synovitis.

Authors:  E B Henderson; M Grootveld; A Farrell; E C Smith; P W Thompson; D R Blake
Journal:  Ann Rheum Dis       Date:  1991-03       Impact factor: 19.103

Review 3.  Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status.

Authors:  P Merry; P G Winyard; C J Morris; M Grootveld; D R Blake
Journal:  Ann Rheum Dis       Date:  1989-10       Impact factor: 19.103

Review 4.  Inhibition of xanthine oxidase by allopurinol: a therapeutic option for ischaemia induced pathological processes?

Authors:  J G Puig; F A Mateos; V D Diaz
Journal:  Ann Rheum Dis       Date:  1989-11       Impact factor: 19.103

5.  Direct assessment of synovial blood flow and its relation to induced hydrostatic pressure changes.

Authors:  P Geborek; K Forslind; F A Wollheim
Journal:  Ann Rheum Dis       Date:  1989-04       Impact factor: 19.103

Review 6.  Hypoxia and inflammatory synovitis: observations and speculation.

Authors:  C R Stevens; R B Williams; A J Farrell; D R Blake
Journal:  Ann Rheum Dis       Date:  1991-02       Impact factor: 19.103

7.  Localisation of xanthine oxidase to synovial endothelium.

Authors:  C R Stevens; M Benboubetra; R Harrison; T Sahinoglu; E C Smith; D R Blake
Journal:  Ann Rheum Dis       Date:  1991-11       Impact factor: 19.103

8.  Free radicals and Dupuytren's contracture.

Authors:  J M Outhwaite; P Merry; R E Allen; D R Blake
Journal:  Br Med J (Clin Res Ed)       Date:  1988-01-23

9.  Electron spin resonance spectroscopic demonstration of the generation of reactive oxygen species by diseased human synovial tissue following ex vivo hypoxia-reoxygenation.

Authors:  D Singh; N B Nazhat; K Fairburn; T Sahinoglu; D R Blake; P Jones
Journal:  Ann Rheum Dis       Date:  1995-02       Impact factor: 19.103

Review 10.  A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase.

Authors:  A Kooij
Journal:  Histochem J       Date:  1994-12
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