Literature DB >> 1772289

Localisation of xanthine oxidase to synovial endothelium.

C R Stevens1, M Benboubetra, R Harrison, T Sahinoglu, E C Smith, D R Blake.   

Abstract

The presence of the xanthine oxidase enzyme system has been demonstrated in the rheumatoid synovium. This supplies a reactive oxygen species generating system to synovium that is subjected to hypoxic-reperfusion cycles (cf inflamed rheumatoid synovium). An antibody to bovine milk xanthine oxidase has been used to localise the enzyme by immunohistochemistry to synovial endothelium. This implicates the endothelial cell as playing a major part in exacerbations of synovitis, induced by radicals.

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Year:  1991        PMID： 1772289      PMCID： PMC1004552          DOI： 10.1136/ard.50.11.760

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  9 in total

1.  Influence of disodium aurothiomalate on the activities of xanthine dehydrogenase and xanthine oxidase in endothelial cells.

Authors:  T Sahinoglu; M Grootveld; C R Stevens; S J Thompson; A W Claxson; D R Blake
Journal:  Agents Actions Suppl       Date:  1991

2.  Superoxide radical generation by inflamed human synovium after hypoxia.

Authors:  R E Allen; D R Blake; N B Nazhat; P Jones
Journal:  Lancet       Date:  1989-07-29       Impact factor: 79.321

3.  Hypoxic-reperfusion injury in the inflamed human joint.

Authors:  D R Blake; P Merry; J Unsworth; B L Kidd; J M Outhwaite; R Ballard; C J Morris; L Gray; J Lunec
Journal:  Lancet       Date:  1989-02-11       Impact factor: 79.321

4.  Inhibition of human endothelial cell proliferation by gold compounds.

Authors:  T Matsubara; M Ziff
Journal:  J Clin Invest       Date:  1987-05       Impact factor: 14.808

5.  Preparation of bovine milk xanthine oxidase as a dehydrogenase form.

Authors:  M Nakamura; I Yamazaki
Journal:  J Biochem       Date:  1982-10       Impact factor: 3.387

6.  Xanthine oxidoreductase is present in human synovium.

Authors:  R E Allen; J M Outhwaite; C J Morris; D R Blake
Journal:  Ann Rheum Dis       Date:  1987-11       Impact factor: 19.103

7.  Significance of xanthine oxidase in capillary endothelial cells.

Authors:  E D Jarasch; G Bruder; H W Heid
Journal:  Acta Physiol Scand Suppl       Date:  1986

8.  Is chronic synovitis an example of reperfusion injury?

Authors:  T Woodruff; D R Blake; J Freeman; F J Andrews; P Salt; J Lunec
Journal:  Ann Rheum Dis       Date:  1986-07       Impact factor: 19.103

9.  The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.

Authors:  E Della Corte; F Stirpe
Journal:  Biochem J       Date:  1972-02       Impact factor: 3.766
  9 in total
  9 in total

1.  Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases.

Authors:  S Basu; M Whiteman; D L Mattey; B Halliwell
Journal:  Ann Rheum Dis       Date:  2001-06       Impact factor: 19.103

2.  Induction and activation of procollagenase in rabbit synovial fibroblasts after treatment with active oxygen released by xanthine/xanthine oxidase.

Authors:  W Ehrlich; H Huser; H Kröger
Journal:  Rheumatol Int       Date:  1995       Impact factor: 2.631

3.  Hydroxyl radical generation by rheumatoid blood and knee joint synovial fluid.

Authors:  H Kaur; S E Edmonds; D R Blake; B Halliwell
Journal:  Ann Rheum Dis       Date:  1996-12       Impact factor: 19.103

4.  The role of human xanthine oxidoreductase (HXOR), anti-HXOR antibodies, and microorganisms in synovial fluid of patients with joint inflammation.

Authors:  Najah Al-Muhtaseb; Elham Al-Kaissi; Abdul Jalil Thawaini; Zuhair Muhi Eldeen; Sabah Al-Muhtaseb; Badiee Al-Saleh
Journal:  Rheumatol Int       Date:  2011-06-05       Impact factor: 2.631

5.  2nd International meeting on synovium cell biology, physiology and pathology. Canterbury, United Kingdom, 21-23 September 1994. Proceedings and abstracts.

Authors: 
Journal:  Ann Rheum Dis       Date:  1995-06       Impact factor: 19.103

Review 6.  Oxygen radicals, nitric oxide and human inflammatory joint disease.

Authors:  B Halliwell
Journal:  Ann Rheum Dis       Date:  1995-06       Impact factor: 19.103

7.  Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study.

Authors:  Seghira Bisset; Widad Sobhi; Ayoub Attoui; Tarek Lamaoui; Yousef A Bin Jardan; Shobhan Das; Manawwer Alam; Khalil Errahmane Kanouni; Abdelmalek Rezgui; Siham Ferdjioui; Yacine Derradji; Abdelhalim Khenchouche; Yacine Benguerba
Journal:  Inflammation       Date:  2022-10-13       Impact factor: 4.657

8.  Electron spin resonance spectroscopic demonstration of the generation of reactive oxygen species by diseased human synovial tissue following ex vivo hypoxia-reoxygenation.

Authors:  D Singh; N B Nazhat; K Fairburn; T Sahinoglu; D R Blake; P Jones
Journal:  Ann Rheum Dis       Date:  1995-02       Impact factor: 19.103

9.  Inhibition of poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts.

Authors:  O Ullrich; W G Siems; K Lehmann; H Huser; W Ehrlich; T Grune
Journal:  Biochem J       Date:  1996-05-01       Impact factor: 3.857
  9 in total

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