Kazuya Nigoro1, Hiromu Ito2,3, Tomotoshi Kawata2, Shinichiro Ishie2, Yugo Morita2, Kohei Nishitani2, Tomoki Aoyama4, Yasuharu Tabara5, Fumihiko Matsuda5, Shu Narumiya1, Shuichi Matsuda2. 1. Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 2. Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. 3. Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan. 4. Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. 5. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Abstract
OBJECTIVE: This cross-sectional study aimed to explore the differences of the medial and lateral sides of the knee joint and precise radiographic abnormalities in contribution to the knee pain and clinical outcomes. DESIGN: Participants 60 years or older who underwent radiographic evaluation were included. Knee radiography was assessed using grading systems of the Osteoarthritis Research Society International (OARSI) atlas. The Japanese Knee Osteoarthritis Measure (JKOM) was evaluated as clinical outcomes. Serum high-sensitivity C-reactive protein (hsCRP) was used to evaluate systemic inflammation. We divided the participants into normal, medial-, lateral-, and medial & lateral-OA types and compared their JKOM using an analysis of covariance. Furthermore, we analyzed the relationship between the knee pain and stiffness of JKOM and the grading of each radiographic feature using a multiple regression model. RESULTS: Lateral- and medial & lateral-OA groups had a significantly worse symptoms in the total and the pain score, especially in movement subscales, in JKOM score. Lateral-OA groups had higher hsCRP than medial-OA group. Multivariate analysis showed that medial joint space narrowing (JSN), and lateral femoral and tibial osteophytes significantly affected knee pain (adjusted odds ratios: 1.73, 1.28, and 1.55, respectively). The radiographic changes are associated with pain more in JSN in the medial side and osteophytes in the lateral side. CONCLUSION: Lateral- and medial & lateral-OA groups showed worth symptom. In addition, medial JSN and lateral osteophytes have potent effects on the knee pain.
OBJECTIVE: This cross-sectional study aimed to explore the differences of the medial and lateral sides of the knee joint and precise radiographic abnormalities in contribution to the knee pain and clinical outcomes. DESIGN: Participants 60 years or older who underwent radiographic evaluation were included. Knee radiography was assessed using grading systems of the Osteoarthritis Research Society International (OARSI) atlas. The Japanese Knee Osteoarthritis Measure (JKOM) was evaluated as clinical outcomes. Serum high-sensitivity C-reactive protein (hsCRP) was used to evaluate systemic inflammation. We divided the participants into normal, medial-, lateral-, and medial & lateral-OA types and compared their JKOM using an analysis of covariance. Furthermore, we analyzed the relationship between the knee pain and stiffness of JKOM and the grading of each radiographic feature using a multiple regression model. RESULTS: Lateral- and medial & lateral-OA groups had a significantly worse symptoms in the total and the pain score, especially in movement subscales, in JKOM score. Lateral-OA groups had higher hsCRP than medial-OA group. Multivariate analysis showed that medial joint space narrowing (JSN), and lateral femoral and tibial osteophytes significantly affected knee pain (adjusted odds ratios: 1.73, 1.28, and 1.55, respectively). The radiographic changes are associated with pain more in JSN in the medial side and osteophytes in the lateral side. CONCLUSION: Lateral- and medial & lateral-OA groups showed worth symptom. In addition, medial JSN and lateral osteophytes have potent effects on the knee pain.
Authors: H Iijima; T Aoyama; K Nishitani; H Ito; N Fukutani; T Isho; E Kaneda; H Kuroki; S Matsuda Journal: Osteoarthritis Cartilage Date: 2017-03-03 Impact factor: 6.576
Authors: K M Leyland; L S Gates; M Nevitt; D Felson; S M Bierma-Zeinstra; P G Conaghan; L Engebretsen; M Hochberg; D J Hunter; G Jones; J M Jordan; A Judge; L S Lohmander; E M Roos; M T Sanchez-Santos; N Yoshimura; J B J van Meurs; M E Batt; J Newton; C Cooper; N K Arden Journal: Osteoarthritis Cartilage Date: 2018-02-07 Impact factor: 6.576
Authors: Z Zhu; L L Laslett; W Han; B Antony; F Pan; F Cicuttini; G Jones; C Ding Journal: Osteoarthritis Cartilage Date: 2017-09-19 Impact factor: 6.576