Thomas A Wadden1, Ariana M Chao2, Harelda Anderson3, Kirsten Annis4, Karen Atkinson5, Paula Bolin3, Phillip Brantley6, Jeanne M Clark7, Mace Coday8, Gareth Dutton9, John P Foreyt10, Edward W Gregg11, Helen P Hazuda12, James O Hill9, Van S Hubbard13, John M Jakicic14, Robert W Jeffery15, Karen C Johnson16, Steven E Kahn5, William C Knowler3, Mary Korytkowski17, Cora E Lewis18, Blandine Laferrère19, Roeland J Middelbeek20, Medha N Munshi20, David M Nathan21, Rebecca H Neiberg22, Scott J Pilla7, Anne Peters23, Xavier Pi-Sunyer19, Jack W Rejeski24, Bruce Redmon25, Tiffany Stewart6, Elizabeth Vaughan10, Lynne E Wagenknecht26, Michael P Walkup22, Rena R Wing4, Holly Wyatt27, Susan Z Yanovski13, Ping Zhang28. 1. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 2. Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 3. Southwestern American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, and Shiprock, New Mexico, USA. 4. Department of Psychiatry, the Miriam Hospital, Alpert Medical School, Brown University, Providence, Rhode Island, USA. 5. Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, USA. 6. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. 7. Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA. 8. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA. 9. Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA. 10. Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. 11. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. 12. Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. 13. Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. 14. Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 15. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA. 16. Departments of Preventive Medicine and Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA. 17. Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 18. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA. 19. Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA. 20. Joslin Diabetes Center, Boston, Massachusetts, USA. 21. Diabetes Center, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts, USA. 22. Department of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA. 23. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. 24. Department of Health and Exercise Sciences, Wake Forest University, Winston-Salem, North Carolina, USA. 25. Department of Medicine, University of Minnesota Medical School, Twin Cities, Minneapolis, Minnesota, USA. 26. Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. 27. Department of Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA. 28. Centers for Disease Control and Prevention, DDT Health Economics Workgroup Atlanta, Atlanta, Georgia, USA.
Abstract
OBJECTIVE: The Action for Health in Diabetes (Look AHEAD) study previously reported that intensive lifestyle intervention (ILI) reduced incident depressive symptoms and improved health-related quality of life (HRQOL) over nearly 10 years of intervention compared with a control group (the diabetes support and education group [DSE]) in participants with type 2 diabetes and overweight or obesity. The present study compared incident depressive symptoms and changes in HRQOL in these groups for an additional 6 years following termination of the ILI in September 2012. METHODS: A total of 1,945 ILI participants and 1,900 DSE participants completed at least one of four planned postintervention assessments at which weight, mood (via the Patient Health Questionnaire-9), antidepressant medication use, and HRQOL (via the Medical Outcomes Scale, Short Form-36) were measured. RESULTS: ILI participants and DSE participants lost 3.1 (0.3) and 3.8 (0.3) kg [represented as mean (SE); p = 0.10], respectively, during the 6-year postintervention follow-up. No significant differences were observed between groups during this time in incident mild or greater symptoms of depression, antidepressant medication use, or in changes on the physical component summary or mental component summary scores of the Short Form-36. In both groups, mental component summary scores were higher than physical component summary scores. CONCLUSIONS: Prior participation in the ILI, compared with the DSE group, did not appear to improve subsequent mood or HRQOL during 6 years of postintervention follow-up.
OBJECTIVE: The Action for Health in Diabetes (Look AHEAD) study previously reported that intensive lifestyle intervention (ILI) reduced incident depressive symptoms and improved health-related quality of life (HRQOL) over nearly 10 years of intervention compared with a control group (the diabetes support and education group [DSE]) in participants with type 2 diabetes and overweight or obesity. The present study compared incident depressive symptoms and changes in HRQOL in these groups for an additional 6 years following termination of the ILI in September 2012. METHODS: A total of 1,945 ILI participants and 1,900 DSE participants completed at least one of four planned postintervention assessments at which weight, mood (via the Patient Health Questionnaire-9), antidepressant medication use, and HRQOL (via the Medical Outcomes Scale, Short Form-36) were measured. RESULTS: ILI participants and DSE participants lost 3.1 (0.3) and 3.8 (0.3) kg [represented as mean (SE); p = 0.10], respectively, during the 6-year postintervention follow-up. No significant differences were observed between groups during this time in incident mild or greater symptoms of depression, antidepressant medication use, or in changes on the physical component summary or mental component summary scores of the Short Form-36. In both groups, mental component summary scores were higher than physical component summary scores. CONCLUSIONS: Prior participation in the ILI, compared with the DSE group, did not appear to improve subsequent mood or HRQOL during 6 years of postintervention follow-up.
Authors: David M Nathan; Patricia A Cleary; Jye-Yu C Backlund; Saul M Genuth; John M Lachin; Trevor J Orchard; Philip Raskin; Bernard Zinman Journal: N Engl J Med Date: 2005-12-22 Impact factor: 91.245
Authors: M Schunk; P Reitmeir; S Schipf; H Völzke; C Meisinger; B Thorand; A Kluttig; K-H Greiser; K Berger; G Müller; U Ellert; H Neuhauser; T Tamayo; W Rathmann; R Holle Journal: Diabet Med Date: 2012-05 Impact factor: 4.359
Authors: Chiadi U Onyike; Rosa M Crum; Hochang B Lee; Constantine G Lyketsos; William W Eaton Journal: Am J Epidemiol Date: 2003-12-15 Impact factor: 4.897
Authors: Helen P Hazuda; Sarah A Gaussoin; Rena R Wing; Susan Z Yanovski; Karen C Johnson; Mace Coday; Thomas A Wadden; Edward S Horton; Brent Van Dorsten; William C Knowler Journal: Diabetes Care Date: 2019-03-04 Impact factor: 19.112
Authors: Donna H Ryan; Mark A Espeland; Gary D Foster; Steven M Haffner; Van S Hubbard; Karen C Johnson; Steven E Kahn; William C Knowler; Susan Z Yanovski Journal: Control Clin Trials Date: 2003-10
Authors: Samuel B Harvey; Simon Øverland; Stephani L Hatch; Simon Wessely; Arnstein Mykletun; Matthew Hotopf Journal: Am J Psychiatry Date: 2017-10-03 Impact factor: 18.112
Authors: Ariana M Chao; Thomas A Wadden; Jeanne M Clark; Kathleen M Hayden; Marjorie J Howard; Karen C Johnson; Blandine Laferrère; Jeanne M McCaffery; Rena R Wing; Susan Z Yanovski; Lynne E Wagenknecht Journal: Diabetes Care Date: 2022-01-01 Impact factor: 17.152
Authors: Rena R Wing; Rebecca H Neiberg; Judy L Bahnson; Jeanne M Clark; Mark A Espeland; James O Hill; Karen C Johnson; William C Knowler; KayLoni Olson; Helmut Steinburg; Xavier Pi-Sunyer; Thomas A Wadden; Holly Wyatt; Jeanne M Clark; Lee Swartz; Dawn Jiggetts; Jeanne Charleston; Lawrence Cheskin; Nisa M Maruthur; Scott J Pilla; Danielle Diggins; Mia Johnson; George A Bray; Frank L Greenway; Donna H Ryan; Catherine Champagne; Valerie Myers; Jeffrey Keller; Tiffany Stewart; Jennifer Arceneaux; Karen Boley; Greta Fry; Lisa Jones; Kim Landry; Melissa Lingle; Marisa Smith; Cora E Lewis; Sheikilya Thomas; Stephen Glasser; Gareth Dutton; Amy Dobelstein; Sara Hannum; Anne Hubbell; DeLavallade Lee; Phyllis Millhouse; L Christie Oden; Cathy Roche; Jackie Grant; Janet Turman; David M Nathan; Valerie Goldman; Linda Delahanty; Mary Larkin; Kristen Dalton; Roshni Singh; Melanie Ruazol; Medha N Munshi; Sharon D Jackson; Roeland J W Middelbeek; A Enrique Caballero; Anthony Rodriguez; George Blackburn; Christos Mantzoros; Ann McNamara; Holly Wyatt; James O Hill; Jeanne Anne Breen; Marsha Miller; Debbie Bochert; Suzette Bossart; Paulette Cohrs; Susan Green; April Hamilton; Eugene Leshchinskiy; Loretta Rome; John P Foreyt; Molly Gee; Henry Pownall; Ashok Balasubramanyam; Chu-Huang Chen; Peter Jones; Michele Burrington; Allyson Clark Gardner; Sharon Griggs; Michelle Hamilton; Veronica Holley; Sarah Lee; Sarah Lane Liscum; Susan Cantu-Lumbreras; Julieta Palencia; Jennifer Schmidt; Jayne Thomas; Carolyn White; Charlyne Wright; Monica Alvarez; Karen C Johnson; Beate Griffin; Mace Coday; Donna Valenski; Lisa Jones; Karen Johnson; Karen C Johnson; Helmut Steinburg; Robert W Jeffery; Tricia Skarphol; John P Bantle; J Bruce Redmon; Kerrin Brelje; Carolyne Campbell; Mary Ann Forseth; Soni Uccellini; Mary Susan Voeller; Blandine Laferrère; Xavier Pi-Sunyer; Jennifer Patricio; Jose Luchsinger; Priya Palta; Sarah Lyon; Kim Kelly; Thomas A Wadden; Barbara J Maschak-Carey; Robert I Berkowitz; Ariana Chao; Renee Davenport; Katherine Gruber; Sharon Leonard; Olivia Walsh; John M Jakicic; Jacqueline Wesche-Thobaben; Lin Ewing; Andrea Hergenroeder; Mary Korytkowski; Susan Copelli; Rebecca Danchenko; Diane Ives; Juliet Mancino; Lisa Martich; Meghan McGuire; Tracey Y Murray; Linda Semler; Kathy Williams; Rena R Wing; Caitlin Egan; Elissa Jelalian; Jeanne McCaffery; Kathryn Demos McDermott; Jessica Unick; Kirsten Annis; Jose DaCruz; Ariana Rafanelli; Helen P Hazuda; Juan Carlos Isaac; Prepedigna Hernandez; Steven E Kahn; Edward J Boyko; Elaine Tsai; Lorena Wright; Karen Atkinson; Ivy Morgan-Taggart; Jolanta Socha; Heidi Urquhart; William C Knowler; Paula Bolin; Harelda Anderson; Sara Michaels; Ruby Johnson; Patricia Poorthunder; Janelia Smiley; Anne L Peters; Siran Ghazarian; Elizabeth Beale; Edgar Ramirez; Gabriela Rodriguez; Valerie Ruelas; Sara Serafin-Dokhan; Martha Walker; Marina Perez; Mark A Espeland; Lynne E Wagenknecht; Judy L Bahnson; David Reboussin; Mike E Miller; Peter Brubaker; Nicholas Pajewski; Michael Bancks; Jingzhong Ding; Gagan Deep; Kathleen Hayden; Stephen R Rapp; Felicia Simpson; Haiying Chen; Bonnie C Sachs; Denise Houston; Shyh-Huei Chen; Andrea Anderson; Jerry M Barnes; Mary Barr; Tara D Beckner; Delilah R Cook; Carrie C Williams; Joni Evans; Katie Garcia; Sarah A Gaussoin; Carol Kittel; Lea Harvin; Marjorie Howard; James Lovato; Rebecca H Neiberg; June Pierce; Debbie Steinberg; Christopher Webb; Jennifer Walker; Michael P Walkup; Carolyn Watkins; Santica M Marcovina; Jessica Hurting; John J Albers; Vinod Gaur; Michael Nevitt; Ann Schwartz; John Shepherd; Michaela Rahorst; Lisa Palermo; Susan Ewing; Cynthia Hayashi; Jason Maeda Journal: Diabetes Care Date: 2022-04-14 Impact factor: 17.152