Jianguo Liu1, Liehui Xiao1, Hezhongrong Nie1, Yong Pan2, Yan Liu1, Zhentian Zhang1, Xiuping Lin1, Yuan Zhang1, Jinchuang Cai1, Muxiu Yang1, Yajing Liu1, Leijun Zhang3, Aimin Xu4,5, Cuifeng Zhu6,7,8. 1. Shenzhen Hospital of Southern Medical University, University of Hong Kong, Shenzhen, China. 2. Department of Pathophysiology, School of Basic Medical Sciences, Shenzhen University, Guangdong, Shenzhen, 518000, China. 3. Shenzhen Hospital of Southern Medical University, University of Hong Kong, Shenzhen, China. 228802383@qq.com. 4. Department of Medicine, University of Hong Kong, Shenzhen, Hong Kong, China. amxu@hku.hk. 5. State Key Laboratory of Pharmaceutical Biotechnology, Shenzhen, Hong Kong, China. amxu@hku.hk. 6. Shenzhen Hospital of Southern Medical University, University of Hong Kong, Shenzhen, China. 1794371266@qq.com. 7. Department of Medicine, University of Hong Kong, Shenzhen, Hong Kong, China. 1794371266@qq.com. 8. State Key Laboratory of Pharmaceutical Biotechnology, Shenzhen, Hong Kong, China. 1794371266@qq.com.
Abstract
OBJECTIVE: To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients. METHODS:From August 2017 to July 2020, 66 obese patients were recruited, and administrated with an modified low-carbon diet with (group A) or without (Group B) microecology preparation and a balanced diet in control group (group C) for 6 months. Meanwhile, 20 volunteers administrated with a balanced diet were recruited as the healthy control group (group D). RESULTS: After 6-month intervention, obese subjects in group A and B showed significant improvement of body and liver fat mass, reduction of serum lipid levels, intestinal barrier function markers, insulin resistance index (IRI), high blood pressure (HBP) and carotid intima thickness, as compared with subjects in group C. More importantly, subjects in group A had better improvement of vascular endothelial elasticity and intimal thickness than subjects in group B. However, these intervention had no effect on carotid atherosclerotic plaque. CONCLUSION: Administration of microecological preparation combined with modified low-carbon diet had better improvement of intestinal barrier function, glucose and lipid metabolism, and cardiovascular complications than low-carbon diet in obese patients, but the effect of a simple low-carb diet on carotid atherosclerotic plaque need to be further addressed.
RCT Entities:
OBJECTIVE: To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obesepatients. METHODS: From August 2017 to July 2020, 66 obesepatients were recruited, and administrated with an modified low-carbon diet with (group A) or without (Group B) microecology preparation and a balanced diet in control group (group C) for 6 months. Meanwhile, 20 volunteers administrated with a balanced diet were recruited as the healthy control group (group D). RESULTS: After 6-month intervention, obese subjects in group A and B showed significant improvement of body and liver fat mass, reduction of serum lipid levels, intestinal barrier function markers, insulin resistance index (IRI), high blood pressure (HBP) and carotid intima thickness, as compared with subjects in group C. More importantly, subjects in group A had better improvement of vascular endothelial elasticity and intimal thickness than subjects in group B. However, these intervention had no effect on carotid atherosclerotic plaque. CONCLUSION: Administration of microecological preparation combined with modified low-carbon diet had better improvement of intestinal barrier function, glucose and lipid metabolism, and cardiovascular complications than low-carbon diet in obesepatients, but the effect of a simple low-carb diet on carotid atherosclerotic plaque need to be further addressed.
Authors: Hai Cheng Zhou; Ya Xin Lai; Zhong Yan Shan; Wei Ping Jia; Wen Ying Yang; Ju Ming Lu; Jian Ping Weng; Li Nong Ji; Jie Liu; Hao Ming Tian; Qiu He Ji; Da Long Zhu; Li Chen; Xiao Hui Guo; Zhi Gang Zhao; Qiang Li; Zhi Guang Zhou; Jia Pu Ge; Guang Liang Shan Journal: Biomed Environ Sci Date: 2014-05 Impact factor: 3.118