Li Ma1, Miaoqian Wang2, Wenbo Li1, Wei Liu3, Hong Yang4, Yuxin Jiang1, Qingli Zhu1. 1. Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. 2. Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Beijing, China. 3. Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. 4. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Abstract
BACKGROUND: Intestinal Behçet's disease (BD) and Crohn's disease (CD) are two diseases that commonly involve the ileocecal region and are difficult to differentiate. We aimed to investigate the value of intestinal ultrasound (IUS) in differentiating between these diseases. METHODS: In this case-control study, patients diagnosed with intestinal BD or CD in the ileocecal region involved were recruited. The IUS characteristics of the two disease groups in terms of disease location, ileocecal region characteristics, and complications were compared. The differences were analyzed using univariate and multivariate analyses. RESULTS: We consecutively enrolled 22 intestinal BD and 44 age- and sex-matched CD patients. On univariate analysis, focal lesion, ileocecal region involvement only, presence of ulcers on ultrasound (US), large ulcers (>2 cm) on US, and fistulas were significantly more common in intestinal BD than in CD, whereas small intestine involvement was significantly more common in CD. On multivariate analysis, focal lesion [odds ratio (OR) 0.156, 95% confidence interval (CI): 0.043-0.564], and large ulcers (OR 0.056, 95% CI: 0.006-0.550) were independent predictors of intestinal BD over CD. The area under the curve for the receiver-operating characteristic was 0.808 (95% CI: 0.706-0.929), and the sensitivity and specificity with a cutoff value of 0.7 were 75.0% and 77.3%, respectively. CONCLUSIONS: IUS can provide useful information for the differential diagnosis of intestinal BD and CD. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: Intestinal Behçet's disease (BD) and Crohn's disease (CD) are two diseases that commonly involve the ileocecal region and are difficult to differentiate. We aimed to investigate the value of intestinal ultrasound (IUS) in differentiating between these diseases. METHODS: In this case-control study, patients diagnosed with intestinal BD or CD in the ileocecal region involved were recruited. The IUS characteristics of the two disease groups in terms of disease location, ileocecal region characteristics, and complications were compared. The differences were analyzed using univariate and multivariate analyses. RESULTS: We consecutively enrolled 22 intestinal BD and 44 age- and sex-matched CD patients. On univariate analysis, focal lesion, ileocecal region involvement only, presence of ulcers on ultrasound (US), large ulcers (>2 cm) on US, and fistulas were significantly more common in intestinal BD than in CD, whereas small intestine involvement was significantly more common in CD. On multivariate analysis, focal lesion [odds ratio (OR) 0.156, 95% confidence interval (CI): 0.043-0.564], and large ulcers (OR 0.056, 95% CI: 0.006-0.550) were independent predictors of intestinal BD over CD. The area under the curve for the receiver-operating characteristic was 0.808 (95% CI: 0.706-0.929), and the sensitivity and specificity with a cutoff value of 0.7 were 75.0% and 77.3%, respectively. CONCLUSIONS: IUS can provide useful information for the differential diagnosis of intestinal BD and CD. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: Christian Maaser; Andreas Sturm; Stephan R Vavricka; Torsten Kucharzik; Gionata Fiorino; Vito Annese; Emma Calabrese; Daniel C Baumgart; Dominik Bettenworth; Paula Borralho Nunes; Johan Burisch; Fabiana Castiglione; Rami Eliakim; Pierre Ellul; Yago González-Lama; Hannah Gordon; Steve Halligan; Konstantinos Katsanos; Uri Kopylov; Paulo G Kotze; Eduards Krustinš; Andrea Laghi; Jimmy K Limdi; Florian Rieder; Jordi Rimola; Stuart A Taylor; Damian Tolan; Patrick van Rheenen; Bram Verstockt; Jaap Stoker Journal: J Crohns Colitis Date: 2019-02-01 Impact factor: 9.071