Literature DB >> 34240333

San Antonio Nathan Shock Center: your one-stop shop for aging research.

Adam B Salmon1,2,3, James F Nelson1,4, Jonathan A L Gelfond1,5, Martin Javors1,6, Brett Ginsburg1,6, Marisa Lopez-Cruzan1,6, Veronica Galvan1,3,4, Elizabeth Fernandez1,3,7, Nicolas Musi1,3,8, Yuji Ikeno1,3,9, Gene Hubbard1,9, James Lechleiter1,10, Peter J Hornsby1,4, Randy Strong11,12,13.   

Abstract

With evolving cores, enrichment and training programs, and supported research projects, the San Antonio (SA) Nathan Shock Center has for 26 years provided critical support to investigators locally, nationally, and abroad. With its existing and growing intellectual capital, the SA Nathan Shock Center provides to local and external investigators an enhanced platform to conduct horizontally integrated (lifespan, healthspan, pathology, pharmacology) transformative research in the biology of aging, and serves as a springboard for advanced educational and training activities in aging research. The SA Nathan Shock Center consists of six cores: Administrative/Program Enrichment Core, Research Development Core, Aging Animal Models and Longevity Assessment Core, Pathology Core, Analytical Pharmacology and Drug Evaluation Core, and Integrated Physiology of Aging Core. The overarching goal of the SA Nathan Shock Center is to advance knowledge in the basic biology of aging and to identify molecular and cellular mechanisms that will facilitate the development of pharmacologic interventions and other strategies to extend healthy lifespan. In pursuit of this goal, we provide an innovative "one-stop shop" venue to accelerate transformative research in the biology of aging through our integrated research cores. Moreover, we aim to foster and promote career development of early-stage investigators in aging biology through our research development programs, to serve as a resource and partner to investigators from other Shock Centers, and to disseminate scientific knowledge and enhanced awareness about aging research. Overall, the SA Nathan Shock Center aims to be a leader in research that advances our understanding of the biology of aging and development of approaches to improve longevity and healthy aging.
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Entities:  

Keywords:  Biostatistics; Longevity; Pathology; Pharmacology; Physiology; Pilot grants

Mesh:

Year:  2021        PMID: 34240333      PMCID: PMC8599539          DOI: 10.1007/s11357-021-00417-y

Source DB:  PubMed          Journal:  Geroscience        ISSN: 2509-2723            Impact factor:   7.713


  25 in total

1.  Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice.

Authors:  Geneva M Cunningham; Lisa C Flores; Madeline G Roman; Christie Cheng; Sara Dube; Colton Allen; Joseph M Valentine; Gene B Hubbard; Yidong Bai; Thomas L Saunders; Yuji Ikeno
Journal:  Geroscience       Date:  2018-08-18       Impact factor: 7.713

2.  Housing density does not influence the longevity effect of calorie restriction.

Authors:  Yuji Ikeno; Gene B Hubbard; Shuko Lee; Arlan Richardson; Randy Strong; Vivian Diaz; James F Nelson
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2005-12       Impact factor: 6.053

3.  Geroscience: linking aging to chronic disease.

Authors:  Brian K Kennedy; Shelley L Berger; Anne Brunet; Judith Campisi; Ana Maria Cuervo; Elissa S Epel; Claudio Franceschi; Gordon J Lithgow; Richard I Morimoto; Jeffrey E Pessin; Thomas A Rando; Arlan Richardson; Eric E Schadt; Tony Wyss-Coray; Felipe Sierra
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

4.  Reduced expression of MYC increases longevity and enhances healthspan.

Authors:  Jeffrey W Hofmann; Xiaoai Zhao; Marco De Cecco; Abigail L Peterson; Luca Pagliaroli; Jayameenakshi Manivannan; Gene B Hubbard; Yuji Ikeno; Yongqing Zhang; Bin Feng; Xiaxi Li; Thomas Serre; Wenbo Qi; Holly Van Remmen; Richard A Miller; Kevin G Bath; Rafael de Cabo; Haiyan Xu; Nicola Neretti; John M Sedivy
Journal:  Cell       Date:  2015-01-22       Impact factor: 41.582

5.  Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels.

Authors:  Rong Yuan; Shirng-Wern Tsaih; Stefka B Petkova; Caralina Marin de Evsikova; Shuqin Xing; Michael A Marion; Molly A Bogue; Kevin D Mills; Luanne L Peters; Carol J Bult; Clifford J Rosen; John P Sundberg; David E Harrison; Gary A Churchill; Beverly Paigen
Journal:  Aging Cell       Date:  2009-04-09       Impact factor: 9.304

6.  Rapamycin extends life and health in C57BL/6 mice.

Authors:  Yiqiang Zhang; Alex Bokov; John Gelfond; Vanessa Soto; Yuji Ikeno; Gene Hubbard; Vivian Diaz; Lauren Sloane; Keith Maslin; Stephen Treaster; Samantha Réndon; Holly van Remmen; Walter Ward; Martin Javors; Arlan Richardson; Steven N Austad; Kathleen Fischer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-16       Impact factor: 6.053

7.  Plasma glucose and the action of calorie restriction on aging.

Authors:  Roger McCarter; Walter Mejia; Yuji Ikeno; Vincent Monnier; Kristen Kewitt; Michael Gibbs; Alex McMahan; Randy Strong
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2007-10       Impact factor: 6.053

8.  Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Authors:  Sarah J Mitchell; Julio Madrigal-Matute; Morten Scheibye-Knudsen; Evandro Fang; Miguel Aon; José A González-Reyes; Sonia Cortassa; Susmita Kaushik; Marta Gonzalez-Freire; Bindi Patel; Devin Wahl; Ahmed Ali; Miguel Calvo-Rubio; María I Burón; Vincent Guiterrez; Theresa M Ward; Hector H Palacios; Huan Cai; David W Frederick; Christopher Hine; Filomena Broeskamp; Lukas Habering; John Dawson; T Mark Beasley; Junxiang Wan; Yuji Ikeno; Gene Hubbard; Kevin G Becker; Yongqing Zhang; Vilhelm A Bohr; Dan L Longo; Placido Navas; Luigi Ferrucci; David A Sinclair; Pinchas Cohen; Josephine M Egan; James R Mitchell; Joseph A Baur; David B Allison; R Michael Anson; José M Villalba; Frank Madeo; Ana Maria Cuervo; Kevin J Pearson; Donald K Ingram; Michel Bernier; Rafael de Cabo
Journal:  Cell Metab       Date:  2016-06-14       Impact factor: 27.287

9.  Senolytics improve physical function and increase lifespan in old age.

Authors:  Ming Xu; Tamar Pirtskhalava; Joshua N Farr; Bettina M Weigand; Allyson K Palmer; Megan M Weivoda; Christina L Inman; Mikolaj B Ogrodnik; Christine M Hachfeld; Daniel G Fraser; Jennifer L Onken; Kurt O Johnson; Grace C Verzosa; Larissa G P Langhi; Moritz Weigl; Nino Giorgadze; Nathan K LeBrasseur; Jordan D Miller; Diana Jurk; Ravinder J Singh; David B Allison; Keisuke Ejima; Gene B Hubbard; Yuji Ikeno; Hajrunisa Cubro; Vesna D Garovic; Xiaonan Hou; S John Weroha; Paul D Robbins; Laura J Niedernhofer; Sundeep Khosla; Tamara Tchkonia; James L Kirkland
Journal:  Nat Med       Date:  2018-07-09       Impact factor: 53.440

10.  Genetically heterogeneous mice exhibit a female survival advantage that is age- and site-specific: Results from a large multi-site study.

Authors:  Catherine J Cheng; Jonathan A L Gelfond; Randy Strong; James F Nelson
Journal:  Aging Cell       Date:  2019-02-23       Impact factor: 9.304

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