Literature DB >> 34235672

Determining Minimum Inhibitory Concentrations in Liquid Cultures or on Solid Medium.

Qinglan Wang1, Helena I M Boshoff2.   

Abstract

Antimicrobial susceptibility testing is the mainstay of tuberculosis drug development programs. In this chapter, we describe methods for determination of the minimum inhibitory concentration of compounds against Mycobacterium tuberculosis growing in liquid media as a function of carbon source, detergent, and environmental stress imposed by acidic pH as well as reactive nitrogen intermediates. Methods for determining the effect of bovine serum albumin in the growth medium on antimicrobial susceptibility are also described. Finally, we provide a method for antimicrobial susceptibility testing on agar medium.

Entities:  

Keywords:  Acidified medium; Agar MIC; Carbon source; Detergent; Liquid MIC; Minimum inhibitory concentration (MIC); Nitrosative stress

Year:  2021        PMID： 34235672     DOI： 10.1007/978-1-0716-1460-0_26

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery.

Authors:  Thierry Christophe; Fanny Ewann; Hee Kyoung Jeon; Jonathan Cechetto; Priscille Brodin
Journal:  Future Med Chem       Date:  2010-08       Impact factor: 3.808

2.  Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.

Authors:  Feng Wang; Dhinakaran Sambandan; Rajkumar Halder; Jianing Wang; Sarah M Batt; Brian Weinrick; Insha Ahmad; Pengyu Yang; Yong Zhang; John Kim; Morad Hassani; Stanislav Huszar; Claudia Trefzer; Zhenkun Ma; Takushi Kaneko; Khisi E Mdluli; Scott Franzblau; Arnab K Chatterjee; Kai Johnsson; Kai Johnson; Katarina Mikusova; Gurdyal S Besra; Klaus Fütterer; Scott H Robbins; S Whitney Barnes; John R Walker; William R Jacobs; Peter G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-17       Impact factor: 11.205

3.  Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.

Authors:  Sarah Schmidt Grant; Tomohiko Kawate; Partha P Nag; Melanie R Silvis; Katherine Gordon; Sarah A Stanley; Edward Kazyanskaya; Raymond Nietupski; Aaron Golas; Michael Fitzgerald; Sanghyun Cho; Scott G Franzblau; Deborah T Hung
Journal:  ACS Chem Biol       Date:  2013-08-13       Impact factor: 5.100

4.  Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.

Authors:  Julie V Early; Allen Casey; Maria Angeles Martinez-Grau; Isabel C Gonzalez Valcarcel; Michal Vieth; Juliane Ollinger; Mai Ann Bailey; Torey Alling; Megan Files; Yulia Ovechkina; Tanya Parish
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

5.  A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.

Authors:  Puiying A Mak; Srinivasa P S Rao; Mai Ping Tan; Xiuhua Lin; Jason Chyba; Joann Tay; Seow Hwee Ng; Bee Huat Tan; Joseph Cherian; Jeyaraj Duraiswamy; Pablo Bifani; Vivian Lim; Boon Heng Lee; Ngai Ling Ma; David Beer; Pamela Thayalan; Kelli Kuhen; Arnab Chatterjee; Frantisek Supek; Richard Glynne; Jun Zheng; Helena I Boshoff; Clifton E Barry; Thomas Dick; Kevin Pethe; Luis R Camacho
Journal:  ACS Chem Biol       Date:  2012-04-25       Impact factor: 5.100

6.  Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

Authors:  Brian C VanderVen; Ruth J Fahey; Wonsik Lee; Yancheng Liu; Robert B Abramovitch; Christine Memmott; Adam M Crowe; Lindsay D Eltis; Emanuele Perola; David D Deininger; Tiansheng Wang; Christopher P Locher; David G Russell
Journal:  PLoS Pathog       Date:  2015-02-12       Impact factor: 6.823

7.  Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.

Authors:  Lluís Ballell; Robert H Bates; Rob J Young; Daniel Alvarez-Gomez; Emilio Alvarez-Ruiz; Vanessa Barroso; Delia Blanco; Benigno Crespo; Jaime Escribano; Rubén González; Sonia Lozano; Sophie Huss; Angel Santos-Villarejo; José Julio Martín-Plaza; Alfonso Mendoza; María José Rebollo-Lopez; Modesto Remuiñan-Blanco; José Luis Lavandera; Esther Pérez-Herran; Francisco Javier Gamo-Benito; José Francisco García-Bustos; David Barros; Julia P Castro; Nicholas Cammack
Journal:  ChemMedChem       Date:  2013-01-10       Impact factor: 3.466

8.  Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis.

Authors:  Ben Gold; Julia Roberts; Yan Ling; Landys Lopez Quezada; Jou Glasheen; Elaine Ballinger; Selin Somersan-Karakaya; Thulasi Warrier; J David Warren; Carl Nathan
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

9.  Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.

Authors:  Crystal M Darby; Helgi I Ingólfsson; Xiuju Jiang; Chun Shen; Mingna Sun; Nan Zhao; Kristin Burns; Gang Liu; Sabine Ehrt; J David Warren; Olaf S Andersen; Olaf S Anderson; Steven J Brickner; Carl Nathan
Journal:  PLoS One       Date:  2013-07-30       Impact factor: 3.240

10.  Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.

Authors:  Sarah A Stanley; Amy K Barczak; Melanie R Silvis; Samantha S Luo; Kimberly Sogi; Martha Vokes; Mark-Anthony Bray; Anne E Carpenter; Christopher B Moore; Noman Siddiqi; Eric J Rubin; Deborah T Hung
Journal:  PLoS Pathog       Date:  2014-02-20       Impact factor: 6.823
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