OBJECTIVE: To examine the association between single nucleotide polymorphisms (SNPs) rs2228570, rs731236, rs7975232, and rs1544410 and lumbar disc degeneration (LDD) predisposition. METHODS: A search strategy was carried out, and the data were extracted after being chosen by the inclusion and exclusion criteria. Pooled odds ratios and 95% confidence intervals were calculated to assess the association between the aforementioned SNPs and LDD under allelic, dominant, recessive, heterozygous, and homozygous genetic models. In addition, a case-control study involving 46 LDD cases and 45 controls was also performed in the analysis to verify the result. RESULTS: A total of 17 studies were included in this meta-analysis. The pooled results did not show any association between vitamin D receptor (VDR) gene polymorphisms and LDD. But, interestingly, in subgroup analysis, the rs2228570 polymorphism was associated with LDD under the allelic (OR = 0.70, 95% CI = 0.56-0.87, p = 0.002), recessive (OR = 0.60, 95% CI = 0.43-0.84, p = 0.003), and homozygous (OR = 0.47, 95% CI= 0.28-0.79, p = 0.004) genetic models in the Asian population. SNPs rs731236 and rs7975232 still did not show any obvious association. We obtained a similar result from the case-control study: rs2228570 had an obvious relationship with LDD under allelic and homozygous genetic models. At the same time, we found that rs2228570 was also associated with the degree of low back pain (visual analogue scale, VAS score) in LDD population. CONCLUSION: SNP rs2228570 was significantly associated with LDD predisposition and the degree of low back pain in the Asian population.
OBJECTIVE: To examine the association between single nucleotide polymorphisms (SNPs) rs2228570, rs731236, rs7975232, and rs1544410 and lumbar disc degeneration (LDD) predisposition. METHODS: A search strategy was carried out, and the data were extracted after being chosen by the inclusion and exclusion criteria. Pooled odds ratios and 95% confidence intervals were calculated to assess the association between the aforementioned SNPs and LDD under allelic, dominant, recessive, heterozygous, and homozygous genetic models. In addition, a case-control study involving 46 LDD cases and 45 controls was also performed in the analysis to verify the result. RESULTS: A total of 17 studies were included in this meta-analysis. The pooled results did not show any association between vitamin D receptor (VDR) gene polymorphisms and LDD. But, interestingly, in subgroup analysis, the rs2228570 polymorphism was associated with LDD under the allelic (OR = 0.70, 95% CI = 0.56-0.87, p = 0.002), recessive (OR = 0.60, 95% CI = 0.43-0.84, p = 0.003), and homozygous (OR = 0.47, 95% CI= 0.28-0.79, p = 0.004) genetic models in the Asian population. SNPs rs731236 and rs7975232 still did not show any obvious association. We obtained a similar result from the case-control study: rs2228570 had an obvious relationship with LDD under allelic and homozygous genetic models. At the same time, we found that rs2228570 was also associated with the degree of low back pain (visual analogue scale, VAS score) in LDD population. CONCLUSION: SNP rs2228570 was significantly associated with LDD predisposition and the degree of low back pain in the Asian population.
Authors: Pasi J Eskola; Per Kjaer; Iita M Daavittila; Svetlana Solovieva; Annaleena Okuloff; Joan S Sorensen; Niels Wedderkopp; Leena Ala-Kokko; Minna Männikkö; Jaro I Karppinen Journal: Int J Mol Epidemiol Genet Date: 2010-03-29
Authors: N Noponen-Hietala; E Kyllönen; M Männikkö; E Ilkko; J Karppinen; J Ott; L Ala-Kokko Journal: Ann Rheum Dis Date: 2003-12 Impact factor: 19.103
Authors: Sabina Cauci; Marco Viganò; Laura de Girolamo; Paola De Luca; Carlotta Perucca Orfei; Giuseppe Banfi; Giovanni Lombardi; Marco Brayda-Bruno; Alessandra Colombini Journal: Int J Mol Sci Date: 2017-09-29 Impact factor: 5.923