Ali Emami1, Mohammad Reza Nazem2, Reza Shekarriz3, Mehdi Hedayati4. 1. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran. 3. Department of Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: hedayati47@yahoo.com.
Abstract
OBJECTIVE: The aim of this study was to evaluate the micronutrient status of Iranian patients with medullary thyroid carcinoma (MTC) and to analyze potential relationships with respect to MTC risk. METHODS: This was a cross-sectional study (Tehran Thyroid Cancer Survey 2015-2016). We measured and compared preoperative serum calcium, zinc, and vitamins D and E in patients with MTC and healthy controls. Forty cases with MTC and 40 (age-, sex-, and body mass index-matched) healthy controls voluntarily participated in the project. RESULTS: Serum calcium, zinc, and vitamin D and E concentrations were lower in the patients with cancer (PCa < 0.001, PZn = 0.01, PD = 0.056, PE = 0.002) than in the healthy controls. We found that serum calcium remarkably associated with enhanced risk for thyroid cancer (odds ratio [OR], 6.5; P = 0.001). Likewise, serum vitamin E was linked to the risk for cancer (OR, 1.31; P = 0.056). Moreover, serum zinc was correlated with vitamin E and calcium (r = +0.23; P = 0.04 and r = +0.25, P = 0.03; respectively). We also observed a correlation between calcium and vitamin E (r = +0.27; P = 0.02). CONCLUSIONS: A multiple-micronutrient decrease was confirmed in patients with MTC. A low serum calcium level was a potent risk factor for MTC. Findings from the present study suggest that dietary intake and/or supplementation of micronutrients, especially calcium and vitamin E, may be beneficial in reducing the risk for thyroid cancer.
OBJECTIVE: The aim of this study was to evaluate the micronutrient status of Iranian patients with medullary thyroid carcinoma (MTC) and to analyze potential relationships with respect to MTC risk. METHODS: This was a cross-sectional study (Tehran Thyroid Cancer Survey 2015-2016). We measured and compared preoperative serum calcium, zinc, and vitamins D and E in patients with MTC and healthy controls. Forty cases with MTC and 40 (age-, sex-, and body mass index-matched) healthy controls voluntarily participated in the project. RESULTS: Serum calcium, zinc, and vitamin D and E concentrations were lower in the patients with cancer (PCa < 0.001, PZn = 0.01, PD = 0.056, PE = 0.002) than in the healthy controls. We found that serum calcium remarkably associated with enhanced risk for thyroid cancer (odds ratio [OR], 6.5; P = 0.001). Likewise, serum vitamin E was linked to the risk for cancer (OR, 1.31; P = 0.056). Moreover, serum zinc was correlated with vitamin E and calcium (r = +0.23; P = 0.04 and r = +0.25, P = 0.03; respectively). We also observed a correlation between calcium and vitamin E (r = +0.27; P = 0.02). CONCLUSIONS: A multiple-micronutrient decrease was confirmed in patients with MTC. A low serum calcium level was a potent risk factor for MTC. Findings from the present study suggest that dietary intake and/or supplementation of micronutrients, especially calcium and vitamin E, may be beneficial in reducing the risk for thyroid cancer.
Authors: Lara Lima-Antoine; Julianna Lys de Sousa Alves Neri; Thaisa Cristina Tavares de Melo; Isabela Samária Fernandes Leite; Diego Marques da Costa Santos; Jéssica Nayara Góes de Araújo; Ana Gabriella da Costa Lemos Silva; Nathália Kelly de Araújo; Carlos C de Oliveira Ramos; Sheila Ramos de Miranda Henriques Tarrapp; Andre Ducati Luchessi; Clélia de Oliveira Lyra; Karla Danielly da Silva Ribeiro; Vivian Nogueira Silbiger Journal: Eur J Clin Nutr Date: 2021-07-06 Impact factor: 4.016